SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 7 PHE A1361
ALA A1377
ILE A1369
ILE A1292
 None
 0.93A 1oniD-2wqsA:
undetectable
1oniF-2wqsA:
undetectable		 1oniD-2wqsA:
18.54
1oniF-2wqsA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 7 LEU A1342
PHE A1361
LEU A1328
PHE A1305
 None
 0.73A 1wrlE-2wqsA:
undetectable
1wrlF-2wqsA:
undetectable		 1wrlE-2wqsA:
13.58
1wrlF-2wqsA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		3 / 3 TYR A1104
GLU A1301
ASP A1364
 None
 0.77A 3bxoA-2wqsA:
undetectable		 3bxoA-2wqsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		3 / 3 TYR A1104
GLU A1301
ASP A1364
 None
 0.82A 3bxoB-2wqsA:
undetectable		 3bxoB-2wqsA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		5 / 12 ASN A1319
ILE A1386
GLY A1313
ASN A1284
THR A1413
 None
 0.98A 3eeyC-2wqsA:
undetectable		 3eeyC-2wqsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		5 / 12 ASN A1319
ILE A1386
GLY A1313
ASN A1284
THR A1413
 None
 1.02A 3eeyE-2wqsA:
undetectable		 3eeyE-2wqsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		3 / 3 TYR A1303
TYR A1395
GLY A1290
 None
 0.74A 3eteB-2wqsA:
undetectable
3eteD-2wqsA:
undetectable
3eteF-2wqsA:
undetectable		 3eteB-2wqsA:
22.05
3eteD-2wqsA:
22.05
3eteF-2wqsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 5 ILE A1369
PHE A1365
ASP A1364
GLU A1363
 None
 1.08A 3kp6A-2wqsA:
undetectable
3kp6B-2wqsA:
undetectable		 3kp6A-2wqsA:
19.82
3kp6B-2wqsA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 6 LEU A1366
ALA A1377
THR A1322
THR A1346
 None
 1.06A 3mdrA-2wqsA:
undetectable		 3mdrA-2wqsA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		3 / 3 PRO A1135
ASP A1133
GLU A1231
 None
CA  A2414 (-3.2A)
None
 0.88A 3v4tC-2wqsA:
undetectable		 3v4tC-2wqsA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 7 TYR A1230
THR A1218
TYR A1105
ARG A1142
 None
 1.29A 3wipA-2wqsA:
undetectable
3wipB-2wqsA:
undetectable		 3wipA-2wqsA:
20.75
3wipB-2wqsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 8 TYR A1230
THR A1218
TYR A1105
ARG A1142
 None
 1.30A 3wipB-2wqsA:
undetectable
3wipC-2wqsA:
undetectable		 3wipB-2wqsA:
20.75
3wipC-2wqsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 8 TYR A1230
THR A1218
TYR A1105
ARG A1142
 None
 1.32A 3wipC-2wqsA:
undetectable
3wipD-2wqsA:
undetectable		 3wipC-2wqsA:
20.75
3wipD-2wqsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 8 TYR A1230
THR A1218
TYR A1105
ARG A1142
 None
 1.31A 3wipD-2wqsA:
undetectable
3wipE-2wqsA:
undetectable		 3wipD-2wqsA:
20.75
3wipE-2wqsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 7 TYR A1230
THR A1218
TYR A1105
ARG A1142
 None
 1.29A 3wipF-2wqsA:
undetectable
3wipG-2wqsA:
undetectable		 3wipF-2wqsA:
20.75
3wipG-2wqsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 8 ARG A1142
TYR A1230
THR A1218
TYR A1105
 None
 1.28A 3wipF-2wqsA:
undetectable
3wipJ-2wqsA:
undetectable		 3wipF-2wqsA:
20.75
3wipJ-2wqsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		5 / 12 LEU A1111
GLN A1113
GLY A1116
ASN A1241
TYR A1201
 None
 1.36A 5d0yA-2wqsA:
undetectable		 5d0yA-2wqsA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 6 GLY A1318
THR A1317
GLN A1315
TYR A1309
 None
 1.27A 6ag0A-2wqsA:
undetectable		 6ag0A-2wqsA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 2wqs AGGLUTININ RECEPTOR
(Streptococcus
gordonii) 		4 / 6 GLY A1318
THR A1317
GLN A1315
TYR A1309
 None
 1.25A 6ag0C-2wqsA:
undetectable		 6ag0C-2wqsA:
12.68