SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wqw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 VAL A 181
LEU A 193
LEU A 169
ILE A 154
LEU A 135
 None
 1.12A 1qzfA-2wqwA:
undetectable		 1qzfA-2wqwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 VAL A 181
LEU A 193
LEU A 169
ILE A 154
LEU A 135
 None
 1.12A 1qzfB-2wqwA:
undetectable		 1qzfB-2wqwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 VAL A 181
LEU A 193
LEU A 169
ILE A 154
LEU A 135
 None
 1.11A 1qzfC-2wqwA:
undetectable		 1qzfC-2wqwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 VAL A 181
LEU A 193
LEU A 169
ILE A 154
LEU A 135
 None
 1.11A 1qzfD-2wqwA:
undetectable		 1qzfD-2wqwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 VAL A 181
LEU A 193
LEU A 169
ILE A 154
LEU A 135
 None
 1.13A 1qzfE-2wqwA:
undetectable		 1qzfE-2wqwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 THR A  71
THR A  42
PRO A  41
 None
 0.87A 209dC-2wqwA:
undetectable		 209dC-2wqwA:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 8 SER A  49
PHE A  53
LEU A 105
LEU A 116
LEU A 119
 None
 1.41A 2bfpB-2wqwA:
undetectable		 2bfpB-2wqwA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 8 SER A  49
PHE A  53
LEU A 105
LEU A 116
LEU A 119
 None
 1.45A 2bfpC-2wqwA:
undetectable		 2bfpC-2wqwA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		4 / 6 ASN A  99
ASN A  76
ILE A  38
GLN A  72
 PEG  A1322 (-3.6A)
None
None
None
 1.27A 2hkkA-2wqwA:
undetectable		 2hkkA-2wqwA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 8 ILE A 179
LEU A 193
ARG A 184
THR A 186
LEU A 207
 None
 1.40A 3asoN-2wqwA:
undetectable
3asoW-2wqwA:
undetectable		 3asoN-2wqwA:
18.02
3asoW-2wqwA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		6 / 12 LEU A 110
ASN A 108
GLY A 107
ILE A  82
VAL A  91
ILE A  88
 None
 1.43A 3bvbA-2wqwA:
undetectable		 3bvbA-2wqwA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		6 / 12 LEU A 110
ASN A 108
GLY A 107
ILE A  82
VAL A  91
ILE A  88
 None
 1.35A 3bvbB-2wqwA:
undetectable		 3bvbB-2wqwA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 PRO A 164
LEU A 188
ASP A 189
LYS A 209
 None
 1.00A 3lsfH-2wqwA:
undetectable		 3lsfH-2wqwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		4 / 8 SER A 168
LEU A 188
ASP A 189
LYS A 209
 None
 0.98A 3lsfH-2wqwA:
undetectable		 3lsfH-2wqwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		4 / 4 ASN A 108
VAL A  91
THR A  56
ILE A  57
 None
 1.33A 4retA-2wqwA:
undetectable		 4retA-2wqwA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		4 / 4 ASN A 108
VAL A  91
THR A  56
ILE A  57
 None
 1.33A 4retC-2wqwA:
undetectable		 4retC-2wqwA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.88A 4wg0B-2wqwA:
undetectable
4wg0C-2wqwA:
undetectable
4wg0D-2wqwA:
undetectable		 4wg0B-2wqwA:
9.00
4wg0C-2wqwA:
9.00
4wg0D-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		4 / 7 LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.79A 4wg0B-2wqwA:
undetectable
4wg0C-2wqwA:
undetectable		 4wg0B-2wqwA:
9.00
4wg0C-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.87A 4wg0D-2wqwA:
undetectable
4wg0E-2wqwA:
undetectable
4wg0F-2wqwA:
undetectable		 4wg0D-2wqwA:
9.00
4wg0E-2wqwA:
9.00
4wg0F-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		6 / 11 ALA A 307
LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 1.18A 4wg0C-2wqwA:
undetectable
4wg0D-2wqwA:
undetectable
4wg0E-2wqwA:
undetectable		 4wg0C-2wqwA:
9.00
4wg0D-2wqwA:
9.00
4wg0E-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.84A 4wg0F-2wqwA:
undetectable
4wg0G-2wqwA:
undetectable
4wg0H-2wqwA:
undetectable		 4wg0F-2wqwA:
9.00
4wg0G-2wqwA:
9.00
4wg0H-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		6 / 11 ALA A 307
LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 1.18A 4wg0E-2wqwA:
undetectable
4wg0F-2wqwA:
undetectable
4wg0G-2wqwA:
undetectable		 4wg0E-2wqwA:
9.00
4wg0F-2wqwA:
9.00
4wg0G-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.86A 4wg0H-2wqwA:
undetectable
4wg0I-2wqwA:
undetectable
4wg0J-2wqwA:
undetectable		 4wg0H-2wqwA:
9.00
4wg0I-2wqwA:
9.00
4wg0J-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.85A 4wg0G-2wqwA:
undetectable
4wg0H-2wqwA:
undetectable
4wg0I-2wqwA:
undetectable		 4wg0G-2wqwA:
9.00
4wg0H-2wqwA:
9.00
4wg0I-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ASN A 261
LEU A 223
LEU A 226
LEU A 237
LEU A 235
 None
 0.85A 4wg0J-2wqwA:
undetectable
4wg0K-2wqwA:
undetectable
4wg0L-2wqwA:
undetectable		 4wg0J-2wqwA:
9.00
4wg0K-2wqwA:
9.00
4wg0L-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.81A 4wg0I-2wqwA:
undetectable
4wg0J-2wqwA:
undetectable
4wg0K-2wqwA:
undetectable		 4wg0I-2wqwA:
9.00
4wg0J-2wqwA:
9.00
4wg0K-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		4 / 7 ASN A 261
LEU A 223
LEU A 226
LEU A 237
 None
 0.77A 4wg0L-2wqwA:
undetectable
4wg0M-2wqwA:
undetectable		 4wg0L-2wqwA:
9.00
4wg0M-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 ALA A 307
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 1.16A 4wg0K-2wqwA:
undetectable
4wg0L-2wqwA:
undetectable
4wg0M-2wqwA:
undetectable		 4wg0K-2wqwA:
9.00
4wg0L-2wqwA:
9.00
4wg0M-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 11 LEU A 235
LEU A 237
ASN A 261
LEU A 223
LEU A 226
 None
 0.81A 4wg0K-2wqwA:
undetectable
4wg0L-2wqwA:
undetectable
4wg0M-2wqwA:
undetectable		 4wg0K-2wqwA:
9.00
4wg0L-2wqwA:
9.00
4wg0M-2wqwA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.62A 5qgjA-2wqwA:
undetectable		 5qgjA-2wqwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.60A 5qgmA-2wqwA:
undetectable		 5qgmA-2wqwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.68A 5qguA-2wqwA:
undetectable		 5qguA-2wqwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH4_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.70A 5qh4A-2wqwA:
undetectable		 5qh4A-2wqwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.67A 5qh9A-2wqwA:
undetectable		 5qh9A-2wqwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHC_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.70A 5qhcA-2wqwA:
undetectable		 5qhcA-2wqwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.69A 5qheA-2wqwA:
undetectable		 5qheA-2wqwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.69A 5qhfA-2wqwA:
undetectable		 5qhfA-2wqwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHG_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		3 / 3 VAL A 267
VAL A 259
GLN A 240
 None
 0.69A 5qhgA-2wqwA:
undetectable		 5qhgA-2wqwA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 ILE A 220
LEU A 215
PHE A 311
LEU A 204
LEU A 213
 None
 0.99A 5tiwA-2wqwA:
undetectable		 5tiwA-2wqwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2wqw INTERNALIN B
(Listeria
monocytogenes) 		5 / 12 LEU A  61
LEU A  97
PRO A  98
PHE A  48
THR A  42
 None
 1.27A 6debB-2wqwA:
undetectable		 6debB-2wqwA:
15.69