SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wrd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
THR A 154
LEU A 250
GLY A 248
 None
 0.71A 1gtiB-2wrdA:
undetectable		 1gtiB-2wrdA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 MET A 150
LEU A  66
SER A 212
PHE A  99
ILE A 178
 None
 1.47A 1xosA-2wrdA:
undetectable		 1xosA-2wrdA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 LYS A 106
LEU A 109
PHE A 115
LEU A 176
 None
 0.99A 2eilP-2wrdA:
undetectable
2eilW-2wrdA:
undetectable		 2eilP-2wrdA:
18.97
2eilW-2wrdA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LYS A 106
LEU A 109
PHE A 115
LEU A 176
 None
 0.99A 2eimP-2wrdA:
undetectable
2eimW-2wrdA:
undetectable		 2eimP-2wrdA:
18.97
2eimW-2wrdA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLY A  10
GLY A 352
GLY A 349
ILE A 339
VAL A 444
 None
 1.04A 2oxtC-2wrdA:
undetectable		 2oxtC-2wrdA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LYS A 106
LEU A 109
PHE A 115
LEU A 176
 None
 0.94A 3asnP-2wrdA:
undetectable
3asnW-2wrdA:
undetectable		 3asnP-2wrdA:
18.97
3asnW-2wrdA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 LYS A 106
LEU A 109
PHE A 115
LEU A 176
 None
 0.97A 3asoC-2wrdA:
undetectable
3asoJ-2wrdA:
undetectable		 3asoC-2wrdA:
18.97
3asoJ-2wrdA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLY A 286
VAL A 297
ILE A 288
ASN A 289
GLU A  38
 None
 1.21A 3jb2A-2wrdA:
undetectable		 3jb2A-2wrdA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		3 / 3 PHE A 392
SER A 111
SER A  81
 None
 0.98A 3ufgB-2wrdA:
undetectable		 3ufgB-2wrdA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 LEU A  56
PHE A  99
LEU A 108
LEU A 105
TYR A 102
 None
 1.13A 3vw7A-2wrdA:
undetectable		 3vw7A-2wrdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 None
 0.80A 4eq4A-2wrdA:
undetectable		 4eq4A-2wrdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 None
 0.82A 4eqlA-2wrdA:
undetectable		 4eqlA-2wrdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 None
 0.82A 4eqlB-2wrdA:
undetectable		 4eqlB-2wrdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 None
 0.88A 4l39A-2wrdA:
undetectable		 4l39A-2wrdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 None
 0.87A 4l39B-2wrdA:
undetectable		 4l39B-2wrdA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 VAL A 444
TYR A  11
GLY A 465
GLY A 352
ASP A 441
 None
 1.22A 4mmcA-2wrdA:
undetectable		 4mmcA-2wrdA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 LEU A 176
LEU A 105
SER A  60
LEU A  66
ILE A 178
 None
 1.00A 4x1fA-2wrdA:
undetectable		 4x1fA-2wrdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 LEU A 176
LEU A 105
SER A  60
LEU A  66
ILE A 178
 None
 1.01A 4x1gA-2wrdA:
undetectable		 4x1gA-2wrdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 ASN A 243
PHE A 244
SER A 246
TYR A 200
 None
 1.27A 5amiB-2wrdA:
undetectable		 5amiB-2wrdA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LYS A 106
LEU A 109
PHE A 115
LEU A 176
 None
 1.01A 5b3sP-2wrdA:
undetectable		 5b3sP-2wrdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 GLY A 224
GLY A 226
SER A 227
LEU A 225
GLU A 189
 None
 0.98A 5hwkA-2wrdA:
undetectable		 5hwkA-2wrdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 GLY A 224
GLY A 226
SER A 227
LEU A 225
GLU A 189
 None
 0.98A 5hwkB-2wrdA:
undetectable		 5hwkB-2wrdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2wrd HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 LYS A 106
LEU A 109
PHE A 115
LEU A 176
 None
 0.90A 5x19P-2wrdA:
undetectable		 5x19P-2wrdA:
18.97