SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wrt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		3 / 3 ASP A  37
HIS A  31
ASP A  44
 None
 0.60A 1nw5A-2wrtA:
undetectable		 1nw5A-2wrtA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		3 / 3 GLY A 138
ASP A 139
ASN A 135
 None
 0.60A 1vq1A-2wrtA:
undetectable		 1vq1A-2wrtA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		4 / 7 GLY A 211
GLY A 212
VAL A 109
LEU A 165
 None
 0.83A 2oa1B-2wrtA:
undetectable		 2oa1B-2wrtA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		3 / 3 LEU A 186
TYR A  23
GLY A  25
 CL  A1219 ( 4.0A)
None
None
 0.39A 2ocuA-2wrtA:
undetectable		 2ocuA-2wrtA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		3 / 3 PHE A 106
CYH A 110
PHE A 115
 None
 0.80A 3cr5X-2wrtA:
undetectable		 3cr5X-2wrtA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		4 / 6 TRP A  41
ASN A  47
TYR A  57
LEU A  50
 None
 1.47A 4f8yA-2wrtA:
undetectable
4f8yB-2wrtA:
undetectable		 4f8yA-2wrtA:
21.05
4f8yB-2wrtA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		6 / 12 LEU A 137
PHE A 179
ILE A  95
GLY A 145
ILE A 183
VAL A 151
 None
 1.47A 4nkxB-2wrtA:
undetectable		 4nkxB-2wrtA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		4 / 9 GLU A 184
LEU A 176
LEU A 170
ILE A 162
 None
 0.92A 4xtaA-2wrtA:
undetectable		 4xtaA-2wrtA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		3 / 3 LEU A 102
VAL A 151
ASP A 152
 None
 0.56A 4y8wC-2wrtA:
undetectable		 4y8wC-2wrtA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		3 / 3 ARG A 182
LYS A 175
GLU A 178
 None
 0.70A 5d0yA-2wrtA:
undetectable		 5d0yA-2wrtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		5 / 12 ASP A 152
VAL A 151
PHE A 136
LEU A 130
LEU A 176
 None
 1.09A 5tudA-2wrtA:
undetectable		 5tudA-2wrtA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		4 / 5 VAL A  17
ARG A  18
GLY A   6
TYR A   7
 None
 1.42A 5x80A-2wrtA:
undetectable
5x80B-2wrtA:
undetectable		 5x80A-2wrtA:
21.17
5x80B-2wrtA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51
(Fasciola
hepatica) 		4 / 5 GLY A   6
TYR A   7
VAL A  17
ARG A  18
 None
 1.31A 5x80C-2wrtA:
undetectable
5x80D-2wrtA:
undetectable		 5x80C-2wrtA:
21.17
5x80D-2wrtA:
21.17