SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2wry INTERLEUKIN-1BETA
(Gallus
gallus) 		4 / 7 SER A 102
ASP A 101
GLU A 104
GLU A  92
 None
 1.10A 1knyA-2wryA:
undetectable
1knyB-2wryA:
undetectable		 1knyA-2wryA:
21.88
1knyB-2wryA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 2wry INTERLEUKIN-1BETA
(Gallus
gallus) 		4 / 8 SER A 102
ASP A 101
GLU A 104
GLU A  92
 None
 1.11A 1knyA-2wryA:
undetectable
1knyB-2wryA:
undetectable		 1knyA-2wryA:
21.88
1knyB-2wryA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2wry INTERLEUKIN-1BETA
(Gallus
gallus) 		5 / 11 TYR A  77
ALA A  49
ILE A  48
LEU A  30
ILE A 133
 None
 0.91A 2h42A-2wryA:
undetectable		 2h42A-2wryA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wry INTERLEUKIN-1BETA
(Gallus
gallus) 		4 / 8 ILE A  48
LEU A  30
ILE A  14
MET A  78
 None
 0.99A 4xtaB-2wryA:
undetectable		 4xtaB-2wryA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wry INTERLEUKIN-1BETA
(Gallus
gallus) 		5 / 12 GLY A  70
TYR A 157
LEU A 159
LEU A  89
LEU A  30
 None
 1.01A 5ycnA-2wryA:
undetectable		 5ycnA-2wryA:
20.00