SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wrz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		3 / 3 GLN A 168
ILE A 169
TYR A 170
 None
 0.73A 1vifA-2wrzA:
undetectable		 1vifA-2wrzA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 9 PHE A  61
GLY A   6
GLU A  34
ILE A  38
VAL A  40
 None
 1.06A 2drdA-2wrzA:
undetectable		 2drdA-2wrzA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		3 / 3 ASP A  89
ASN A  90
THR A  46
 None
 0.72A 2pymB-2wrzA:
undetectable		 2pymB-2wrzA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		3 / 3 ASP A  89
ASN A  90
THR A  46
 None
 0.71A 2q63B-2wrzA:
undetectable		 2q63B-2wrzA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		3 / 3 ASN A 143
ARG A 149
ASP A 157
 None
 0.99A 2qe6A-2wrzA:
undetectable		 2qe6A-2wrzA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 7 PHE A 248
LEU A 121
ILE A 169
GLY A 228
 None
 0.99A 2v0mC-2wrzA:
undetectable		 2v0mC-2wrzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 9 ALA A  49
ALA A  58
GLY A  60
GLY A   6
ILE A  36
 None
 1.21A 2v7bA-2wrzA:
3.2		 2v7bA-2wrzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 9 ALA A  49
ALA A  58
GLY A  60
GLY A   6
ILE A  36
 None
 1.18A 2v7bB-2wrzA:
4.6		 2v7bB-2wrzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 8 ALA A 215
ASN A 187
ALA A 185
THR A 174
 None
 0.95A 3t3sD-2wrzA:
undetectable		 3t3sD-2wrzA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 151
ARG A 150
ILE A 231
 None
 0.93A 4b7qA-2wrzA:
undetectable		 4b7qA-2wrzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		3 / 3 ARG A 151
ARG A 150
ILE A 231
 None
 0.84A 4b7qC-2wrzA:
undetectable		 4b7qC-2wrzA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 12 PHE A  61
GLY A   6
GLU A  34
ILE A  38
VAL A  40
 None
 1.07A 4u8yB-2wrzA:
undetectable		 4u8yB-2wrzA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 12 PHE A  61
GLY A   6
GLU A  34
ILE A  38
VAL A  40
 None
 1.08A 4u95B-2wrzA:
undetectable		 4u95B-2wrzA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 9 ASP A 206
ILE A 231
GLY A 203
ILE A 140
THR A 147
 None
 1.31A 5kr2A-2wrzA:
undetectable		 5kr2A-2wrzA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		4 / 6 ARG A 214
GLY A 212
THR A 216
GLU A 217
 None
 0.86A 5ny7A-2wrzA:
undetectable		 5ny7A-2wrzA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN
(Escherichia
coli) 		5 / 12 GLY A  60
VAL A  35
ALA A  78
ASP A  82
PHE A  33
 None
 1.08A 6nj9K-2wrzA:
2.9		 6nj9K-2wrzA:
22.02