SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 THR H  66
LEU H  64
GLY H  61
LEU H  59
 None
CLA  H1079 ( 3.9A)
None
None
 1.05A 1gtiD-2wscH:
undetectable		 1gtiD-2wscH:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 7 THR H  66
LEU H  64
GLY H  61
LEU H  59
 None
CLA  H1079 ( 3.9A)
None
None
 0.95A 1gtiE-2wscH:
undetectable		 1gtiE-2wscH:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 8 PHE L 143
LEU L  95
LEU L  64
LEU L  63
 None
BCR  L1169 ( 3.8A)
None
None
 1.00A 2bfpB-2wscL:
undetectable		 2bfpB-2wscL:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 GLY L 135
ASP L 134
SER L 132
 None
 0.72A 2qhfA-2wscL:
undetectable		 2qhfA-2wscL:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ALA L  83
GLY L  72
PRO L  73
LEU L  86
 None
None
CLA  H1079 ( 4.0A)
None
 0.74A 4dubA-2wscL:
undetectable		 4dubA-2wscL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ALA L  82
GLY L  66
PRO L  67
VAL L  65
 None
CLA  L1168 (-2.8A)
CLA  L1168 ( 4.0A)
None
 0.94A 4dubB-2wscL:
undetectable		 4dubB-2wscL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		4 / 6 ALA L  83
GLY L  72
PRO L  73
LEU L  86
 None
None
CLA  H1079 ( 4.0A)
None
 0.76A 4dubB-2wscL:
undetectable		 4dubB-2wscL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 GLY L 150
GLY L 147
PHE H  40
GLY L  57
VAL L  54
 None
 0.77A 4o33A-2wscL:
undetectable		 4o33A-2wscL:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 GLY L 150
GLY L 147
PHE H  40
GLY L  57
VAL L  54
 None
 0.79A 4o3fA-2wscL:
undetectable		 4o3fA-2wscL:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 THR L 152
ALA L  80
GLY L  81
ALA L  83
THR L  77
 None
 1.38A 5l5zH-2wscL:
undetectable
5l5zI-2wscL:
undetectable		 5l5zH-2wscL:
22.92
5l5zI-2wscL:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI,
CHLOROPLASTIC
(Spinacia
oleracea) 		5 / 12 THR L 152
ALA L  80
GLY L  81
ALA L  83
THR L  77
 None
 1.38A 5l5zV-2wscL:
undetectable
5l5zW-2wscL:
undetectable		 5l5zV-2wscL:
22.92
5l5zW-2wscL:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
(Spinacia
oleracea) 		3 / 3 TYR H  24
ASP H  22
GLN H  20
 None
 0.86A 6g1pA-2wscH:
undetectable		 6g1pA-2wscH:
19.13