SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wsi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 148
PHE A  58
SER A  57
LEU A 131
VAL A 120
 FAD  A2762 (-3.0A)
None
None
None
None
 1.39A 1q23C-2wsiA:
undetectable		 1q23C-2wsiA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 5 ALA A  33
ASN A 201
ILE A 202
ASP A 198
 None
 1.09A 1yc2D-2wsiA:
2.4		 1yc2D-2wsiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 5 ALA A  33
ASN A 201
ILE A 202
ASP A 198
 None
 1.08A 2h4jA-2wsiA:
2.2		 2h4jA-2wsiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 218
THR A 115
ILE A 272
GLY A 215
 None
 0.85A 2jkjE-2wsiA:
undetectable		 2jkjE-2wsiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 131
GLU A 133
ASP A 108
SER A 124
 None
 1.29A 3dzgA-2wsiA:
undetectable		 3dzgA-2wsiA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 131
GLU A 133
ASP A 108
SER A 124
 None
 1.29A 3dzgB-2wsiA:
undetectable		 3dzgB-2wsiA:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G59_A_ACTA306_0
(FMN
ADENYLYLTRANSFERASE)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 5 SER A  59
PHE A 148
ILE A 163
TRP A 185
 FAD  A2762 (-3.1A)
FAD  A2762 (-3.0A)
FAD  A2762 (-3.8A)
FAD  A2762 (-3.3A)
 0.75A 3g59A-2wsiA:
38.7		 3g59A-2wsiA:
63.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 SER A 204
PHE A 205
TYR A  17
LEU A  69
 None
 1.09A 3jq7C-2wsiA:
undetectable		 3jq7C-2wsiA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 117
PHE A 106
GLN A 109
 None
FAD  A2762 (-4.9A)
FAD  A2762 ( 4.9A)
 0.97A 3r55A-2wsiA:
undetectable		 3r55A-2wsiA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 222
GLY A 302
PRO A 232
ASN A 233
 None
 1.16A 3u8qA-2wsiA:
undetectable		 3u8qA-2wsiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 148
PHE A  58
SER A  57
LEU A 131
VAL A 120
 FAD  A2762 (-3.0A)
None
None
None
None
 1.49A 3u9fI-2wsiA:
undetectable		 3u9fI-2wsiA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 108
ASN A  61
GLY A 225
GLY A 226
ILE A 227
 None
FAD  A2762 (-4.1A)
None
None
None
 0.88A 3ufnA-2wsiA:
undetectable		 3ufnA-2wsiA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 161
VAL A 162
SER A  59
PHE A  58
LEU A  52
 FAD  A2762 ( 3.7A)
None
FAD  A2762 (-3.1A)
None
None
 1.10A 5ergB-2wsiA:
2.7		 5ergB-2wsiA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 165
THR A  37
LEU A  69
LEU A 191
LEU A  41
 FAD  A2762 (-4.5A)
None
None
None
None
 1.22A 5fhzB-2wsiA:
2.7		 5fhzB-2wsiA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2wsi FAD SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  77
LEU A 102
LEU A 129
LEU A  70
LEU A  72
 None
 0.95A 5nfjA-2wsiA:
undetectable		 5nfjA-2wsiA:
22.36