SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wsm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 8 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 1.01A 1dz9A-2wsmA:
undetectable		 1dz9A-2wsmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 8 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.98A 1iwiA-2wsmA:
undetectable		 1iwiA-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 GLY A 129
GLU A 130
LEU A 103
ILE A  99
LEU A  94
 None
 1.23A 1kyvA-2wsmA:
3.7
1kyvE-2wsmA:
3.2		 1kyvA-2wsmA:
22.87
1kyvE-2wsmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  94
GLY A 129
GLU A 130
LEU A 103
ILE A  99
 None
 1.21A 1kyvB-2wsmA:
4.0
1kyvC-2wsmA:
2.8		 1kyvB-2wsmA:
22.87
1kyvC-2wsmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  94
GLY A 129
GLU A 130
LEU A 103
ILE A  99
 None
 1.18A 1kyvC-2wsmA:
3.3
1kyvD-2wsmA:
4.1		 1kyvC-2wsmA:
22.87
1kyvD-2wsmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  94
GLY A 129
GLU A 130
LEU A 103
ILE A  99
 None
 1.16A 1kyvD-2wsmA:
4.1
1kyvE-2wsmA:
3.6		 1kyvD-2wsmA:
22.87
1kyvE-2wsmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 11 ILE A  47
ALA A  62
GLY A  61
TYR A  73
GLU A 115
 None
 1.40A 1n6cA-2wsmA:
undetectable		 1n6cA-2wsmA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 1.04A 1t85A-2wsmA:
undetectable		 1t85A-2wsmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 1.04A 1t87A-2wsmA:
undetectable		 1t87A-2wsmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 112
LEU A 111
LEU A  25
ILE A  99
ILE A  47
 None
 1.25A 1tw4B-2wsmA:
undetectable		 1tw4B-2wsmA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 8 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.98A 1uyuA-2wsmA:
undetectable		 1uyuA-2wsmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.96A 1yrcA-2wsmA:
undetectable		 1yrcA-2wsmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.99A 1yrdA-2wsmA:
undetectable		 1yrdA-2wsmA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 113
ILE A  35
PHE A 207
VAL A 160
LEU A  46
 None
 1.26A 2bxeB-2wsmA:
undetectable		 2bxeB-2wsmA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 6 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.95A 2feuA-2wsmA:
undetectable		 2feuA-2wsmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.95A 2feuB-2wsmA:
undetectable		 2feuB-2wsmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 ALA A  38
GLU A 141
VAL A 145
ILE A 159
PHE A 153
 None
 0.98A 2qk8A-2wsmA:
3.6		 2qk8A-2wsmA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 6 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 1.02A 2zuhA-2wsmA:
undetectable		 2zuhA-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 6 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.99A 2zuiA-2wsmA:
undetectable		 2zuiA-2wsmA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.98A 2zwtA-2wsmA:
undetectable		 2zwtA-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.97A 2zwuA-2wsmA:
undetectable		 2zwuA-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 10 ALA A  38
GLU A 141
VAL A 145
ILE A 159
PHE A 153
 None
 1.25A 3fl9A-2wsmA:
3.5		 3fl9A-2wsmA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 11 ALA A  38
GLU A 141
VAL A 145
ILE A 159
PHE A 153
 None
 1.27A 3fl9C-2wsmA:
3.1		 3fl9C-2wsmA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 9 ALA A  38
GLU A 141
VAL A 145
ILE A 159
PHE A 153
 None
 1.14A 3fl9D-2wsmA:
3.4		 3fl9D-2wsmA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_E_TOPE200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 10 ALA A  38
GLU A 141
VAL A 145
ILE A 159
PHE A 153
 None
 1.14A 3fl9E-2wsmA:
3.2		 3fl9E-2wsmA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 10 ALA A  38
GLU A 141
VAL A 145
ILE A 159
PHE A 153
 None
 1.20A 3fl9F-2wsmA:
3.6		 3fl9F-2wsmA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 9 ALA A  38
GLU A 141
VAL A 145
ILE A 159
PHE A 153
 None
 1.24A 3fl9H-2wsmA:
3.5		 3fl9H-2wsmA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.96A 3fwfA-2wsmA:
undetectable		 3fwfA-2wsmA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.95A 3fwfB-2wsmA:
undetectable		 3fwfB-2wsmA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.99A 3fwiA-2wsmA:
undetectable		 3fwiA-2wsmA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.98A 3fwjA-2wsmA:
undetectable		 3fwjA-2wsmA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.96A 3l63A-2wsmA:
undetectable		 3l63A-2wsmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		3 / 3 GLY A  40
GLY A  42
THR A  44
 None
 0.45A 3si7B-2wsmA:
undetectable		 3si7B-2wsmA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 10 ILE A 161
GLU A 141
SER A  41
ILE A 159
ALA A 181
 None
 1.35A 3u6tA-2wsmA:
undetectable		 3u6tA-2wsmA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 191
VAL A 134
ILE A 211
LEU A 212
VAL A  58
 None
 1.05A 3w67C-2wsmA:
undetectable		 3w67C-2wsmA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 191
VAL A 134
ILE A 211
LEU A 212
VAL A  58
 None
 1.00A 3w68B-2wsmA:
undetectable		 3w68B-2wsmA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 191
VAL A 134
ILE A 211
LEU A 212
VAL A  58
 None
 1.08A 3w68C-2wsmA:
undetectable		 3w68C-2wsmA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.95A 3wrhA-2wsmA:
undetectable		 3wrhA-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.96A 3wrjA-2wsmA:
undetectable		 3wrjA-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.94A 3wrlA-2wsmA:
undetectable		 3wrlA-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.97A 3wrlE-2wsmA:
undetectable		 3wrlE-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.94A 3wrmA-2wsmA:
undetectable		 3wrmA-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.99A 3wrmF-2wsmA:
undetectable		 3wrmF-2wsmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 ALA A 156
ASP A 157
VAL A 160
ILE A 114
 None
 0.66A 4eyrA-2wsmA:
undetectable		 4eyrA-2wsmA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 8 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.98A 4l4aA-2wsmA:
undetectable		 4l4aA-2wsmA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 8 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.98A 4l4bA-2wsmA:
undetectable		 4l4bA-2wsmA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 8 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.96A 4l4cB-2wsmA:
undetectable		 4l4cB-2wsmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 1.06A 4l4gA-2wsmA:
undetectable		 4l4gA-2wsmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 8 ASN A  34
MET A  36
TYR A 132
GLU A 130
 None
 1.23A 4mj8A-2wsmA:
undetectable
4mj8C-2wsmA:
undetectable		 4mj8A-2wsmA:
21.08
4mj8C-2wsmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 ASN A  34
MET A  36
TYR A 132
GLU A 130
 None
 1.26A 4mj8C-2wsmA:
undetectable		 4mj8C-2wsmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 9 VAL A 145
ALA A 181
ARG A 154
ILE A 159
ILE A 161
 None
 1.48A 4oknB-2wsmA:
3.2		 4oknB-2wsmA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 6 ASN A  34
MET A  36
TYR A 132
GLU A 130
 None
 1.37A 4r87H-2wsmA:
undetectable		 4r87H-2wsmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		3 / 3 TYR A 100
ARG A  16
LYS A  20
 None
 1.35A 4wq5B-2wsmA:
undetectable		 4wq5B-2wsmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 6 GLY A  42
ASN A 162
MET A 136
ILE A  47
 None
 1.13A 5j4nA-2wsmA:
undetectable		 5j4nA-2wsmA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 ARG A  49
LEU A 113
GLU A  52
LEU A 195
 None
 0.66A 5jq7A-2wsmA:
undetectable		 5jq7A-2wsmA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 ARG A  49
LEU A  46
ILE A  60
LEU A 113
 None
 0.92A 5te8C-2wsmA:
undetectable		 5te8C-2wsmA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		4 / 7 THR A  50
LEU A 113
VAL A  33
VAL A 160
 None
 0.99A 5wk9A-2wsmA:
undetectable		 5wk9A-2wsmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 10 LEU A 113
VAL A  58
GLY A  55
TRP A 204
LEU A 208
 None
 1.48A 6bsgA-2wsmA:
undetectable		 6bsgA-2wsmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 10 LEU A 113
VAL A  58
GLY A  55
TRP A 204
LEU A 208
 None
 1.49A 6bsiA-2wsmA:
undetectable		 6bsiA-2wsmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 10 LEU A 113
VAL A  58
GLY A  55
TRP A 204
LEU A 208
 None
 1.50A 6bsjA-2wsmA:
undetectable		 6bsjA-2wsmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)
(Archaeoglobus
fulgidus) 		5 / 12 ARG A  49
LEU A 113
GLU A  52
LEU A 195
LEU A 208
 None
 1.03A 6f6iA-2wsmA:
undetectable
6f6iB-2wsmA:
undetectable		 6f6iA-2wsmA:
17.21
6f6iB-2wsmA:
17.55