SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wt8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2wt8 MICROCEPHALIN
(Homo
sapiens) 		3 / 3 ASP A  54
VAL A  13
ASN A  95
 None
 0.78A 4lmnA-2wt8A:
undetectable		 4lmnA-2wt8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 2wt8 MICROCEPHALIN
(Homo
sapiens) 		4 / 4 LEU A   6
ILE A  51
HIS A  49
VAL A  76
 None
 1.31A 4xyzA-2wt8A:
undetectable		 4xyzA-2wt8A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2wt8 MICROCEPHALIN
(Homo
sapiens) 		3 / 3 MET A  35
GLU A  77
ARG A  80
 None
 1.12A 5tjyA-2wt8A:
4.9		 5tjyA-2wt8A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2wt8 MICROCEPHALIN
(Homo
sapiens) 		5 / 10 VAL A  71
VAL A   9
VAL A  13
ALA A  11
LEU A   6
 None
 1.08A 6czmA-2wt8A:
undetectable
6czmC-2wt8A:
undetectable		 6czmA-2wt8A:
14.76
6czmC-2wt8A:
14.76