SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wtb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 5 ARG A  49
ALA A  19
ASP A  51
GLY A  17
None
0.98A 1e7bA-2wtbA:
undetectable
1e7bA-2wtbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 5 ARG A  49
ALA A  19
ASP A  51
GLY A  17
None
0.87A 1e7cA-2wtbA:
undetectable
1e7cA-2wtbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 ALA A 357
GLY A 326
GLY A 351
GLY A 353
PHE A 450
None
0.90A 1eizA-2wtbA:
6.6
1eizA-2wtbA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 ALA A 357
GLY A 326
GLY A 351
GLY A 353
PHE A 450
None
0.90A 1ej0A-2wtbA:
6.6
1ej0A-2wtbA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
None
1.23A 1jffB-2wtbA:
undetectable
1jffB-2wtbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 SER A 105
ASN A  29
SER A  65
LEU A 120
LEU A  98
None
1.18A 1lhuA-2wtbA:
undetectable
1lhuA-2wtbA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
3 / 3 ARG A 127
ILE A 204
TRP A 200
None
1.13A 1nodB-2wtbA:
undetectable
1nodB-2wtbA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 ALA A 657
ILE A 656
GLY A 670
PHE A 502
None
0.70A 1sv9A-2wtbA:
undetectable
1sv9A-2wtbA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 TYR A  43
LEU A  39
LEU A  36
LEU A  23
LEU A  97
None
1.22A 1tw4B-2wtbA:
undetectable
1tw4B-2wtbA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 10 GLY A 670
HIS A 288
ALA A 675
ILE A 671
SER A 677
None
1.24A 1utdR-2wtbA:
undetectable
1utdS-2wtbA:
undetectable
1utdR-2wtbA:
8.22
1utdS-2wtbA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLY A 117
GLY A 116
GLY A 115
LEU A 135
SER A  30
None
1.21A 1xdsA-2wtbA:
7.8
1xdsA-2wtbA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 546
SER A 428
HIS A 449
GLY A 320
ILE A 317
None
1.30A 1xvaA-2wtbA:
7.1
1xvaA-2wtbA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 ASP A 281
GLY A 669
PHE A 664
TYR A 667
None
1.04A 2aouA-2wtbA:
5.9
2aouA-2wtbA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 LEU A 459
GLY A 663
GLY A 669
GLY A 670
ILE A 671
None
0.85A 2avvA-2wtbA:
undetectable
2avvA-2wtbA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 ARG A 294
THR A 486
GLY A 295
ILE A 656
None
0.88A 2f9wA-2wtbA:
3.2
2f9wB-2wtbA:
2.7
2f9wA-2wtbA:
16.48
2f9wB-2wtbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
6 / 12 GLY A 663
GLY A 669
GLY A 670
ILE A 671
PHE A 673
VAL A 488
None
1.32A 2fxeA-2wtbA:
undetectable
2fxeA-2wtbA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 5 ILE A 462
PRO A 487
PHE A 450
VAL A 479
None
1.30A 2hjhB-2wtbA:
4.9
2hjhB-2wtbA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
None
1.23A 2hxfB-2wtbA:
undetectable
2hxfB-2wtbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
None
1.23A 2hxhB-2wtbA:
undetectable
2hxhB-2wtbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 GLU A 401
ILE A 430
LYS A 406
GLU A 397
None
0.98A 2j9dJ-2wtbA:
undetectable
2j9dK-2wtbA:
undetectable
2j9dL-2wtbA:
undetectable
2j9dJ-2wtbA:
12.23
2j9dK-2wtbA:
12.23
2j9dL-2wtbA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 LYS A 406
ILE A 435
GLU A 401
ILE A 430
None
0.92A 2j9dJ-2wtbA:
undetectable
2j9dK-2wtbA:
undetectable
2j9dL-2wtbA:
undetectable
2j9dJ-2wtbA:
12.23
2j9dK-2wtbA:
12.23
2j9dL-2wtbA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 6 MET A 672
LEU A 654
MET A 501
GLU A 638
None
1.18A 2kuhA-2wtbA:
undetectable
2kuhA-2wtbA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
None
1.23A 2p4nB-2wtbA:
undetectable
2p4nB-2wtbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 9 ILE A 671
GLY A 670
GLY A 669
SER A 680
LEU A 714
None
0.94A 2qmmA-2wtbA:
undetectable
2qmmA-2wtbA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 VAL A 187
SER A 129
ALA A 132
PRO A 190
None
1.15A 2v41G-2wtbA:
2.1
2v41H-2wtbA:
2.0
2v41G-2wtbA:
14.96
2v41H-2wtbA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 11 ALA A 651
ASP A 655
ILE A 671
SER A 680
ILE A 683
None
1.09A 2w9sA-2wtbA:
undetectable
2w9sA-2wtbA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 11 ALA A 651
ASP A 655
ILE A 671
SER A 680
ILE A 683
None
1.09A 2w9sB-2wtbA:
undetectable
2w9sB-2wtbA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 10 ALA A 651
ASP A 655
ILE A 671
SER A 680
ILE A 683
None
1.07A 2w9sC-2wtbA:
undetectable
2w9sC-2wtbA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
None
1.23A 2wbeB-2wtbA:
undetectable
2wbeB-2wtbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 ILE A 683
GLY A 679
TYR A 682
GLY A 708
ARG A 686
None
1.34A 2y7kC-2wtbA:
undetectable
2y7kC-2wtbA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 PHE A 450
GLY A 326
ILE A 317
ALA A 398
None
0.95A 3aodA-2wtbA:
undetectable
3aodA-2wtbA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
3 / 3 CYH A 640
PHE A 643
PHE A 703
None
0.88A 3cr5X-2wtbA:
undetectable
3cr5X-2wtbA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
None
1.23A 3dcoB-2wtbA:
undetectable
3dcoB-2wtbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
3 / 3 ARG A 127
ILE A 204
TRP A 200
None
1.06A 3e7iB-2wtbA:
undetectable
3e7iB-2wtbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 LEU A 135
GLY A 116
ILE A 109
VAL A  35
ILE A  24
None
1.00A 3frqB-2wtbA:
undetectable
3frqB-2wtbA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
6 / 12 VAL A 273
ALA A 254
GLU A 139
LEU A 137
ILE A 167
THR A 151
None
1.46A 3gcsA-2wtbA:
undetectable
3gcsA-2wtbA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 ILE A 327
LEU A 476
VAL A 446
VAL A 472
ILE A 312
None
1.05A 3gwxB-2wtbA:
undetectable
3gwxB-2wtbA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 7 TYR A 684
GLU A 706
LEU A 687
ASN A 637
None
1.06A 3k8mA-2wtbA:
undetectable
3k8mA-2wtbA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 446
ILE A 473
ILE A 317
HIS A 449
VAL A 489
None
1.31A 4a97B-2wtbA:
undetectable
4a97C-2wtbA:
undetectable
4a97B-2wtbA:
17.37
4a97C-2wtbA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
3 / 3 ASN A 492
ASP A 431
ASN A 433
None
0.63A 4agaA-2wtbA:
undetectable
4agaA-2wtbA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
3 / 3 ASN A  25
LEU A 112
PHE A  68
None
0.71A 4dajB-2wtbA:
undetectable
4dajB-2wtbA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 ILE A 678
ILE A 671
PHE A 673
GLY A 285
None
0.76A 4hdlA-2wtbA:
undetectable
4hdlA-2wtbA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 ILE A 659
LEU A 249
LEU A 239
LEU A 286
HIS A 247
None
1.34A 4j03A-2wtbA:
2.2
4j03A-2wtbA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 5 GLY A 149
LEU A  98
ILE A  89
LEU A  31
LEU A 183
None
1.37A 4o8fA-2wtbA:
undetectable
4o8fA-2wtbA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 5 GLY A 447
LEU A 413
ILE A 435
LEU A 331
None
0.87A 4o8fA-2wtbA:
undetectable
4o8fA-2wtbA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
6 / 12 ASP A 253
LEU A 231
LEU A 164
ILE A 167
LEU A 168
ILE A 145
None
1.31A 4odrA-2wtbA:
undetectable
4odrB-2wtbA:
undetectable
4odrA-2wtbA:
8.97
4odrB-2wtbA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 9 ILE A 647
VAL A 490
GLY A 495
SER A 425
VAL A 463
None
0.88A 4r20B-2wtbA:
undetectable
4r20B-2wtbA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 9 ILE A 647
VAL A 490
GLY A 495
SER A 425
VAL A 463
None
1.03A 4r21B-2wtbA:
undetectable
4r21B-2wtbA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLY A 116
GLY A 115
GLY A 147
ILE A  91
TYR A  88
None
1.01A 4rtmA-2wtbA:
6.4
4rtmA-2wtbA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
3 / 3 LYS A 103
ILE A  55
ILE A  21
None
0.70A 4y0qA-2wtbA:
undetectable
4y0qA-2wtbA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 6 PHE A 511
GLY A 695
TYR A 694
ALA A 693
None
1.07A 4yshB-2wtbA:
undetectable
4yshB-2wtbA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 9 THR A 218
LEU A 221
PRO A 263
ILE A 259
LEU A 160
None
1.46A 5g48B-2wtbA:
undetectable
5g48B-2wtbA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
None
1.16A 5hnwB-2wtbA:
undetectable
5hnwB-2wtbA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
None
1.24A 5hnxB-2wtbA:
undetectable
5hnxB-2wtbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 VAL A 277
HIS A 247
LEU A 168
THR A 169
PRO A 146
None
1.23A 5hnyB-2wtbA:
undetectable
5hnyB-2wtbA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 ILE A 445
GLU A 414
PHE A 410
ARG A 438
GLY A 436
None
1.29A 5il1A-2wtbA:
undetectable
5il1A-2wtbA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 ASN A 358
ALA A 357
SER A 361
HIS A 455
None
1.07A 5km8A-2wtbA:
undetectable
5km8B-2wtbA:
undetectable
5km8A-2wtbA:
12.28
5km8B-2wtbA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
6 / 12 GLY A  87
PHE A 148
GLY A 143
VAL A 278
THR A 151
GLY A 149
None
1.44A 5koxA-2wtbA:
undetectable
5koxA-2wtbA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 ALA A 497
VAL A 488
GLY A 658
ILE A 671
None
0.64A 5kr1B-2wtbA:
undetectable
5kr1B-2wtbA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 11 ILE A 671
GLY A 670
GLY A 669
SER A 680
LEU A 714
None
0.88A 5twjD-2wtbA:
undetectable
5twjD-2wtbA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLU A 139
GLY A 150
VAL A  35
LEU A  23
GLY A  67
None
1.08A 5vooA-2wtbA:
3.2
5vooA-2wtbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLU A 139
GLY A 150
VAL A  35
LEU A  23
GLY A  67
None
1.08A 5vooB-2wtbA:
3.5
5vooB-2wtbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLU A 139
GLY A 150
VAL A  35
LEU A  23
GLY A  67
None
1.07A 5vooC-2wtbA:
undetectable
5vooC-2wtbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLU A 139
GLY A 150
VAL A  35
LEU A  23
GLY A  67
None
1.11A 5vooD-2wtbA:
undetectable
5vooD-2wtbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLU A 139
GLY A 150
VAL A  35
LEU A  23
GLY A  67
None
1.18A 5vooE-2wtbA:
undetectable
5vooE-2wtbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLU A 139
GLY A 150
VAL A  35
LEU A  23
GLY A  67
None
1.15A 5vooF-2wtbA:
4.2
5vooF-2wtbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLU A 139
GLY A 150
VAL A  35
LEU A  23
GLY A  67
None
1.07A 5vopA-2wtbA:
2.2
5vopA-2wtbA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLY A 115
ILE A  94
LEU A 120
GLY A 117
GLY A 116
None
0.94A 5wyqB-2wtbA:
undetectable
5wyqB-2wtbA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 8 LEU A 193
LEU A 114
ALA A 113
LEU A 135
None
0.88A 5y7pC-2wtbA:
undetectable
5y7pC-2wtbA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
4 / 4 GLY A 661
LEU A 459
VAL A 498
GLU A 461
None
1.37A 5yw0A-2wtbA:
undetectable
5yw0A-2wtbA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 LEU A  98
ILE A  94
PHE A  64
GLY A 117
LEU A  39
None
1.24A 6a7pA-2wtbA:
undetectable
6a7pA-2wtbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_0
(ADENOSYLHOMOCYSTEINA
SE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 10 GLY A 319
GLY A 321
GLU A 342
VAL A 343
ILE A 409
None
0.63A 6exiA-2wtbA:
3.8
6exiA-2wtbA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_1
(ADENOSYLHOMOCYSTEINA
SE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 10 GLY A 319
GLY A 321
GLU A 342
VAL A 343
ILE A 409
None
0.62A 6exiB-2wtbA:
3.5
6exiB-2wtbA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC503_0
(ADENOSYLHOMOCYSTEINA
SE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLY A 319
GLY A 321
GLU A 342
VAL A 343
ILE A 409
None
0.64A 6exiC-2wtbA:
undetectable
6exiD-2wtbA:
4.0
6exiC-2wtbA:
8.28
6exiD-2wtbA:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND503_0
(ADENOSYLHOMOCYSTEINA
SE)
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana)
5 / 12 GLY A 319
GLY A 321
GLU A 342
VAL A 343
ILE A 409
None
0.63A 6exiC-2wtbA:
undetectable
6exiD-2wtbA:
4.0
6exiC-2wtbA:
8.28
6exiD-2wtbA:
8.28