SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wte'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 2wte CSA3
(Sulfolobus
solfataricus) 		5 / 11 ILE A  82
LEU A  93
PHE A   5
ILE A 100
ILE A  78
 None
 0.98A 1dyrA-2wteA:
undetectable		 1dyrA-2wteA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2wte CSA3
(Sulfolobus
solfataricus) 		4 / 5 GLU A  21
LEU A  15
LEU A  18
LEU A  16
 None
 1.01A 1np1A-2wteA:
undetectable		 1np1A-2wteA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wte CSA3
(Sulfolobus
solfataricus) 		3 / 3 GLU A  47
GLU A  12
LEU A  30
 None
 0.75A 1v8bA-2wteA:
undetectable		 1v8bA-2wteA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2wte CSA3
(Sulfolobus
solfataricus) 		5 / 12 ILE A  46
ILE A  90
SER A  91
ALA A  24
PHE A  14
 None
 1.20A 2ejtA-2wteA:
3.7		 2ejtA-2wteA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2wte CSA3
(Sulfolobus
solfataricus) 		4 / 8 TYR A  58
ARG A 120
VAL A   6
TYR A   4
 None
 0.98A 2fl5E-2wteA:
undetectable
2fl5F-2wteA:
undetectable		 2fl5E-2wteA:
21.25
2fl5F-2wteA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2wte CSA3
(Sulfolobus
solfataricus) 		4 / 8 TYR A  58
GLU A  21
VAL A   6
TYR A   4
 None
 1.13A 2fl5E-2wteA:
undetectable
2fl5F-2wteA:
undetectable		 2fl5E-2wteA:
21.25
2fl5F-2wteA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2wte CSA3
(Sulfolobus
solfataricus) 		5 / 11 ILE A 162
GLY A 159
THR A 157
LEU A 150
GLY A 161
 None
 1.08A 2fn1A-2wteA:
undetectable		 2fn1A-2wteA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 2wte CSA3
(Sulfolobus
solfataricus) 		5 / 12 LEU A  56
ALA A  51
ILE A  53
SER A  48
LEU A  49
 None
 1.24A 3gyqA-2wteA:
undetectable
3gyqB-2wteA:
2.7		 3gyqA-2wteA:
22.97
3gyqB-2wteA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 2wte CSA3
(Sulfolobus
solfataricus) 		4 / 5 ASP A  92
LEU A  93
ILE A  89
PHE A 115
 None
 1.17A 3s3vA-2wteA:
1.3		 3s3vA-2wteA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ8_A_TOPA2001_1
(DIHYDROFOLATE
REDUCTASE)		 2wte CSA3
(Sulfolobus
solfataricus) 		5 / 9 ILE A  82
LEU A  93
PHE A   5
ILE A 100
ILE A  78
 None
 0.97A 3tq8A-2wteA:
2.1		 3tq8A-2wteA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wte CSA3
(Sulfolobus
solfataricus) 		4 / 8 ILE A  53
ARG A  50
LEU A  49
VAL A   6
 None
 0.86A 3w1wA-2wteA:
4.7		 3w1wA-2wteA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 2wte CSA3
(Sulfolobus
solfataricus) 		4 / 4 ASN A 101
GLY A  96
ASP A  28
ASP A  92
 None
 1.25A 4n49A-2wteA:
2.8		 4n49A-2wteA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2wte CSA3
(Sulfolobus
solfataricus) 		4 / 6 ARG A  43
GLU A  47
GLU A  65
VAL A  34
 None
 1.26A 5h4dA-2wteA:
2.8		 5h4dA-2wteA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2wte CSA3
(Sulfolobus
solfataricus) 		5 / 12 ILE A  66
ILE A  68
VAL A  33
THR A   7
ILE A 104
 None
 1.08A 5lg3E-2wteA:
undetectable		 5lg3E-2wteA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2wte CSA3
(Sulfolobus
solfataricus) 		5 / 10 ILE A  66
ILE A  68
VAL A  33
THR A   7
ILE A 104
 None
 1.08A 5lg3F-2wteA:
undetectable		 5lg3F-2wteA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 2wte CSA3
(Sulfolobus
solfataricus) 		4 / 8 ARG A 120
VAL A   6
ASP A  92
TYR A 118
 None
 0.81A 5vlmA-2wteA:
2.6		 5vlmA-2wteA:
18.67