SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wtg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJO_A_EAAA211_1 (GLUTATHIONE S-TRANSFERASE P)	2wtg	GLOBIN-LIKE PROTEIN (Caenorhabditis elegans)	4 / 8	PHE A 90 VAL A 83 ILE A 98 GLY A 92	None	0.95A	3hjoA-2wtgA: undetectable	3hjoA-2wtgA: 19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3S_D_9PLD1_1 (CYTOCHROME P450 2A13)	2wtg	GLOBIN-LIKE PROTEIN (Caenorhabditis elegans)	4 / 8	PHE A 118 PHE A 115 PHE A 114 ALA A 76	None None HEM A 180 (-3.7A) HEM A 180 (-3.6A)	0.86A	3t3sD-2wtgA: undetectable	3t3sD-2wtgA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZW_A_SAMA1451_0 (WBDD)	2wtg	GLOBIN-LIKE PROTEIN (Caenorhabditis elegans)	5 / 12	ASN A 41 ARG A 36 GLU A 29 LEU A 128 VAL A 125	None	1.23A	4azwA-2wtgA: undetectable	4azwA-2wtgA: 15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OKT_A_198A1001_1 (ANDROGEN RECEPTOR)	2wtg	GLOBIN-LIKE PROTEIN (Caenorhabditis elegans)	5 / 12	LEU A 80 LEU A 139 GLY A 140 ARG A 5 MET A 112	HEM A 180 (-4.7A) None None None None	1.38A	4oktA-2wtgA: undetectable	4oktA-2wtgA: 19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DLV_A_5D5A930_0 (ECTONUCLEOTIDE PYROPHOSPHATASE/PHOS PHODIESTERASE FAMILY MEMBER 2)	2wtg	GLOBIN-LIKE PROTEIN (Caenorhabditis elegans)	5 / 12	THR A 40 HIS A 101 PHE A 34 ARG A 19 TYR A 121	None HEM A 180 (-3.3A) None None None	1.44A	5dlvA-2wtgA: undetectable	5dlvA-2wtgA: 12.18

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3HJO_A_EAAA211_1","GLUTATHIONE S-TRANSFERASE P","2wtg","GLOBIN-LIKE PROTEIN","Caenorhabditis elegans",4,"PHE A  90;VAL A  83;ILE A  98;GLY A  92","None","0.95A","3hjoA-2wtgA:undetectable","3hjoA-2wtgA:19.07"],["3T3S_D_9PLD1_1","CYTOCHROME P450 2A13","2wtg","GLOBIN-LIKE PROTEIN","Caenorhabditis elegans",4,"PHE A 118;PHE A 115;PHE A 114;ALA A  76","None;None;HEM A 180 (-3.7A);HEM A 180 (-3.6A)","0.86A","3t3sD-2wtgA:undetectable","3t3sD-2wtgA:16.67"],["4AZW_A_SAMA1451_0","WBDD","2wtg","GLOBIN-LIKE PROTEIN","Caenorhabditis elegans",5,"ASN A  41;ARG A  36;GLU A  29;LEU A 128;VAL A 125","None","1.23A","4azwA-2wtgA:undetectable","4azwA-2wtgA:15.14"],["4OKT_A_198A1001_1","ANDROGEN RECEPTOR","2wtg","GLOBIN-LIKE PROTEIN","Caenorhabditis elegans",5,"LEU A  80;LEU A 139;GLY A 140;ARG A   5;MET A 112","HEM A 180 (-4.7A);None;None;None;None","1.38A","4oktA-2wtgA:undetectable","4oktA-2wtgA:19.46"],["5DLV_A_5D5A930_0","ECTONUCLEOTIDE PYROPHOSPHATASE\/PHOSPHODIESTERASE FAMILY MEMBER 2","2wtg","GLOBIN-LIKE PROTEIN","Caenorhabditis elegans",5,"THR A  40;HIS A 101;PHE A  34;ARG A  19;TYR A 121","None;HEM A 180 (-3.3A);None;None;None","1.44A","5dlvA-2wtgA:undetectable","5dlvA-2wtgA:12.18"]]