SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wtk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 8 PHE B 355
LEU B 360
HIS B 353
LEU B 299
 None
 1.00A 1cmaA-2wtkB:
undetectable
1cmaB-2wtkB:
undetectable		 1cmaA-2wtkB:
13.40
1cmaB-2wtkB:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 VAL B 121
LEU B 124
LEU B 214
GLY B 190
SER B 219
 None
 0.99A 1cqeA-2wtkB:
undetectable		 1cqeA-2wtkB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 VAL B 121
LEU B 124
LEU B 214
GLY B 190
SER B 219
 None
 1.01A 1cqeB-2wtkB:
undetectable		 1cqeB-2wtkB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 10 LEU C  72
ASP C  68
ASP C 115
VAL C  66
GLY C  47
 None
 1.15A 1d4sA-2wtkC:
undetectable		 1d4sA-2wtkC:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 6 VAL B 121
VAL B 131
MET B 150
ARG B 194
 None
 1.09A 1iepA-2wtkB:
22.4		 1iepA-2wtkB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		5 / 7 VAL B 121
VAL B 131
MET B 150
ARG B 194
LEU B 202
 None
None
None
None
ANP  B 432 ( 4.7A)
 0.76A 1iepB-2wtkB:
22.5		 1iepB-2wtkB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 9 LEU C  55
GLY C  56
VAL C  63
ALA C  76
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.80A 1muoA-2wtkC:
9.9		 1muoA-2wtkC:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		6 / 12 VAL B  85
GLU B 118
VAL B 131
THR B 147
PHE B 149
GLY B 153
 ANP  B 432 (-4.6A)
None
None
ANP  B 432 (-4.3A)
ANP  B 432 ( 4.9A)
ANP  B 432 ( 4.2A)
 0.85A 1opjB-2wtkB:
22.0		 1opjB-2wtkB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 12 ALA C  76
LEU C 102
CYH C 132
LEU C 167
HIS C 174
 ANP  C   2 (-3.4A)
None
ANP  C   2 (-4.5A)
None
None
 0.65A 1uwhA-2wtkC:
23.7		 1uwhA-2wtkC:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 12 ALA C  76
LYS C  78
LEU C 102
CYH C 132
LEU C 167
HIS C 174
 ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
ANP  C   2 (-4.5A)
None
None
 0.68A 1uwhB-2wtkC:
23.5		 1uwhB-2wtkC:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 6 ILE B  75
VAL B  85
VAL B 121
ILE B 130
 ANP  B 432 (-4.4A)
ANP  B 432 (-4.6A)
None
None
 0.79A 1uwhB-2wtkB:
23.4		 1uwhB-2wtkB:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		3 / 3 SER B 212
ASP B 157
CYH B 160
 None
ANP  B 432 (-2.9A)
None
 0.93A 2br4E-2wtkB:
undetectable		 2br4E-2wtkB:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		7 / 12 VAL B  85
GLU B 118
VAL B 131
THR B 147
PHE B 149
GLY B 153
LEU B 202
 ANP  B 432 (-4.6A)
None
None
ANP  B 432 (-4.3A)
ANP  B 432 ( 4.9A)
ANP  B 432 ( 4.2A)
ANP  B 432 ( 4.7A)
 0.80A 2hyyC-2wtkB:
22.5		 2hyyC-2wtkB:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ASN B 252
ARG C 331
ASP B 365
 None
 1.00A 2qe6A-2wtkB:
undetectable		 2qe6A-2wtkB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 8 LEU C 182
ILE C 177
HIS C 174
GLY C 215
 None
 0.89A 3b9lA-2wtkC:
undetectable		 3b9lA-2wtkC:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 5 LEU C 182
GLN C 159
HIS C 174
LEU C 167
 None
 1.25A 3ce6D-2wtkC:
undetectable		 3ce6D-2wtkC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 5 PRO B 128
ILE B 130
PRO B 132
TYR B 210
 None
 1.33A 3d9lA-2wtkB:
undetectable
3d9lY-2wtkB:
undetectable		 3d9lA-2wtkB:
16.14
3d9lY-2wtkB:
3.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		8 / 12 LEU C  55
GLY C  56
GLY C  58
GLY C  61
VAL C  63
ALA C  76
MET C 129
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.65A 3eygA-2wtkC:
25.0		 3eygA-2wtkC:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		8 / 12 GLY C  56
GLY C  58
GLY C  61
VAL C  63
ALA C  76
MET C 129
TYR C 131
LEU C 183
 ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
 0.73A 3fupA-2wtkC:
25.2		 3fupA-2wtkC:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		8 / 12 LEU C  55
GLY C  56
GLY C  58
GLY C  61
VAL C  63
ALA C  76
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.62A 3fupA-2wtkC:
25.2		 3fupA-2wtkC:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		8 / 12 LEU C  55
GLY C  56
GLY C  61
VAL C  63
ALA C  76
LYS C  78
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
None
 0.81A 3fupA-2wtkC:
25.2		 3fupA-2wtkC:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 11 LEU C  55
VAL C  63
ALA C  76
TYR C 131
CYH C 132
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
ANP  C   2 (-4.5A)
None
 0.64A 3g0fA-2wtkC:
21.8		 3g0fA-2wtkC:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 10 LEU C  55
VAL C  63
ALA C  76
TYR C 131
CYH C 132
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
ANP  C   2 (-4.5A)
None
 0.60A 3g0fB-2wtkC:
21.8		 3g0fB-2wtkC:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 12 VAL C  63
ALA C  76
GLU C  98
LEU C 102
ILE C 111
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
 0.97A 3gcsA-2wtkC:
21.4		 3gcsA-2wtkC:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 12 VAL C  63
ALA C  76
GLU C  98
LEU C 101
LEU C 102
ILE C 111
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
None
 0.93A 3gp0A-2wtkC:
21.9		 3gp0A-2wtkC:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 12 VAL C  63
ALA C  76
LEU C 101
LEU C 102
ILE C 111
HIS C 174
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
None
 0.79A 3gp0A-2wtkC:
21.9		 3gp0A-2wtkC:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		3 / 3 GLY C 270
PRO C 254
LEU C 290
 None
 0.60A 3hcpB-2wtkC:
undetectable		 3hcpB-2wtkC:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		3 / 3 GLY B  67
PRO B  92
LEU B  63
 None
 0.58A 3hcpB-2wtkB:
undetectable		 3hcpB-2wtkB:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 12 ALA C  76
LYS C  78
GLU C  98
LEU C 195
LEU C 102
ILE C 111
 ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
None
None
None
 1.25A 3hegA-2wtkC:
21.6		 3hegA-2wtkC:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 12 VAL C  63
ALA C  76
LYS C  78
GLU C  98
LEU C 102
ILE C 111
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
None
None
 0.89A 3hegA-2wtkC:
21.6		 3hegA-2wtkC:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 6 VAL C 110
ILE C 172
HIS C 174
ILE C 192
 None
 0.37A 3hegA-2wtkC:
21.6		 3hegA-2wtkC:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		3 / 3 SER B 195
GLY B 213
SER B 199
 None
None
ANP  B 432 (-3.6A)
 0.66A 3loqA-2wtkB:
undetectable		 3loqA-2wtkB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 7 SER B 195
TYR B 133
ASN B 217
LEU B 214
 None
 1.43A 3lslA-2wtkB:
undetectable
3lslD-2wtkB:
undetectable		 3lslA-2wtkB:
21.11
3lslD-2wtkB:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		8 / 12 LEU C  55
GLY C  56
GLY C  58
VAL C  63
ALA C  76
ILE C 111
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
 0.63A 3lxnA-2wtkC:
25.3		 3lxnA-2wtkC:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		7 / 11 ILE B  75
VAL B 131
PHE B 149
MET B 150
GLY B 153
LEU B 202
SER B 212
 ANP  B 432 (-4.4A)
None
ANP  B 432 ( 4.9A)
None
ANP  B 432 ( 4.2A)
ANP  B 432 ( 4.7A)
None
 0.89A 3miyA-2wtkB:
24.4		 3miyA-2wtkB:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		6 / 9 ILE B  75
PHE B 149
MET B 150
GLY B 153
LEU B 202
SER B 212
 ANP  B 432 (-4.4A)
ANP  B 432 ( 4.9A)
None
ANP  B 432 ( 4.2A)
ANP  B 432 ( 4.7A)
None
 0.88A 3miyB-2wtkB:
24.3		 3miyB-2wtkB:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 6 VAL B  85
VAL B 121
VAL B 131
MET B 150
 ANP  B 432 (-4.6A)
None
None
None
 0.95A 3mssD-2wtkB:
22.1		 3mssD-2wtkB:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 12 GLY C  56
VAL C  63
ALA C  76
LYS C  78
LEU C 102
ILE C 111
 ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
None
 0.73A 3ohtA-2wtkC:
5.1		 3ohtA-2wtkC:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 12 GLY C  56
VAL C  63
ALA C  76
LYS C  78
ILE C 111
 ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
 0.53A 3ohtB-2wtkC:
18.0		 3ohtB-2wtkC:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 12 GLY C  56
VAL C  63
LYS C  78
LEU C 102
ILE C 111
GLY C 135
 ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
 1.42A 3ohtB-2wtkC:
18.0		 3ohtB-2wtkC:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 7 LYS C  78
LEU C 105
VAL C 110
LEU C 183
 ANP  C   2 (-3.6A)
None
None
None
 0.60A 3rgfA-2wtkC:
8.6		 3rgfA-2wtkC:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 7 LEU B 158
GLY B  76
ILE B  75
THR B 161
 None
ANP  B 432 (-3.4A)
ANP  B 432 (-4.4A)
None
 0.83A 3spkB-2wtkB:
undetectable		 3spkB-2wtkB:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		5 / 11 PHE B 149
PHE B 415
ILE B  75
GLY B  76
LEU B 202
 ANP  B 432 ( 4.9A)
ANP  B 432 ( 4.9A)
ANP  B 432 (-4.4A)
ANP  B 432 (-3.4A)
ANP  B 432 ( 4.7A)
 1.13A 3t3rA-2wtkB:
undetectable		 3t3rA-2wtkB:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 12 GLY C  58
GLY C  61
VAL C  63
ALA C  76
LEU C 183
SER C 193
 ANP  C   2 (-3.0A)
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.73A 3v5wA-2wtkC:
10.3		 3v5wA-2wtkC:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 12 LEU C 182
THR C 249
ILE C 248
ILE C 192
LEU C 285
 None
 1.07A 3vw1B-2wtkC:
undetectable		 3vw1B-2wtkC:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 8 VAL C 110
CYH C 132
LEU C 183
ILE C 192
 None
ANP  C   2 (-4.5A)
None
None
 0.28A 3wzeA-2wtkC:
21.8		 3wzeA-2wtkC:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		7 / 12 VAL C  63
ALA C  76
GLU C  98
ILE C 111
MET C 127
TYR C 131
LEU C 183
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
None
None
 1.43A 4bkjA-2wtkC:
22.0		 4bkjA-2wtkC:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 8 THR C 249
LEU C 290
LEU C 286
GLY C 242
THR C 244
 None
 1.44A 4c9nA-2wtkC:
undetectable		 4c9nA-2wtkC:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 11 LEU C  55
GLY C  56
GLY C  58
VAL C  63
ALA C  76
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
 0.83A 4ckiA-2wtkC:
26.4		 4ckiA-2wtkC:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 11 LEU C  55
GLY C  56
VAL C  63
ALA C  76
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.53A 4ckiA-2wtkC:
26.4		 4ckiA-2wtkC:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 10 LEU C  55
GLY C  56
VAL C  63
ALA C  76
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.46A 4ckjA-2wtkC:
26.5		 4ckjA-2wtkC:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 LEU B 390
ALA B 273
PHE B 378
PHE B 352
PHE B 379
 None
 1.41A 4iaqA-2wtkB:
undetectable		 4iaqA-2wtkB:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		3 / 3 VAL C  66
GLY C  52
LYS C  64
 None
 0.76A 4k50E-2wtkC:
undetectable		 4k50E-2wtkC:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		6 / 10 ILE B  75
VAL B 131
PHE B 149
GLY B 153
LEU B 202
SER B 212
 ANP  B 432 (-4.4A)
None
ANP  B 432 ( 4.9A)
ANP  B 432 ( 4.2A)
ANP  B 432 ( 4.7A)
None
 0.86A 4ks8A-2wtkB:
25.7		 4ks8A-2wtkB:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 7 VAL C  63
ALA C  76
LEU C  80
MET C 129
LEU C 183
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
 0.90A 4l9iA-2wtkC:
24.5		 4l9iA-2wtkC:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 8 GLY C  58
VAL C  63
ALA C  76
LYS C  78
MET C 129
LEU C 183
 ANP  C   2 (-3.0A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
None
 0.77A 4l9iB-2wtkC:
29.0		 4l9iB-2wtkC:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 8 SER C 216
ASP C 176
GLN C 220
VAL C 243
THR C 244
 None
 1.39A 4lnwA-2wtkC:
undetectable		 4lnwA-2wtkC:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 6 SER C 216
GLN C 220
VAL C 243
THR C 244
 None
 0.97A 4lnxA-2wtkC:
undetectable		 4lnxA-2wtkC:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXY_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		8 / 12 LEU C  55
VAL C  63
ALA C  76
LYS C  78
GLU C  98
MET C 129
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
None
None
None
 0.95A 4mxyA-2wtkC:
17.6		 4mxyA-2wtkC:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MXZ_A_DB8A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		8 / 12 LEU C  55
VAL C  63
ALA C  76
LYS C  78
GLU C  98
MET C 129
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
None
None
None
 0.95A 4mxzA-2wtkC:
17.6		 4mxzA-2wtkC:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 6 LEU C  55
GLY C  56
VAL C  63
ALA C  76
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
 0.49A 4o0wA-2wtkC:
29.7		 4o0wA-2wtkC:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTI_A_MI1A1001_1
(SERINE/THREONINE-PRO
TEIN KINASE N1)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		8 / 12 LEU C  55
GLY C  56
GLY C  58
GLY C  61
VAL C  63
ALA C  76
LYS C  78
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
 0.55A 4otiA-2wtkC:
17.4		 4otiA-2wtkC:
28.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 12 GLY C  56
VAL C  63
ALA C  76
MET C 129
TYR C 131
LEU C 183
 ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
 0.57A 4qmzA-2wtkC:
22.8		 4qmzA-2wtkC:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 6 LEU C  55
VAL C  63
LYS C  78
ILE C 192
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
 0.64A 4tyjA-2wtkC:
22.7		 4tyjA-2wtkC:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 7 VAL C  63
LYS C  78
ILE C 111
ILE C 192
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
 0.65A 4uxqA-2wtkC:
22.4		 4uxqA-2wtkC:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		7 / 9 LEU C  55
VAL C  63
LYS C  78
ILE C 111
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
None
 0.73A 4v01A-2wtkC:
22.3		 4v01A-2wtkC:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 9 LEU C  55
VAL C  63
ILE C 111
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
None
None
None
None
 0.72A 4v01B-2wtkC:
22.7		 4v01B-2wtkC:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 9 LEU C  55
VAL C  63
LYS C  78
ILE C 111
LEU C 183
ILE C 192
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
 0.76A 4v01B-2wtkC:
22.7		 4v01B-2wtkC:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 8 LYS C  78
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 (-3.6A)
None
None
None
 0.73A 4v04A-2wtkC:
15.6		 4v04A-2wtkC:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 10 LEU C  55
VAL C  63
LYS C  78
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
 0.75A 4v04B-2wtkC:
22.7		 4v04B-2wtkC:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 10 VAL C  63
LYS C  78
ILE C 111
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
None
 0.84A 4v04B-2wtkC:
22.7		 4v04B-2wtkC:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_B_ANWB601_0
(RHODOPSIN KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 8 LEU C  55
ALA C  76
MET C 129
LEU C 183
SER C 193
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.4A)
None
None
None
 0.86A 4wboB-2wtkC:
28.7		 4wboB-2wtkC:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 6 LEU C  55
ALA C  76
MET C 129
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.4A)
None
None
 0.71A 4wboC-2wtkC:
28.7		 4wboC-2wtkC:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 9 PHE C 264
ALA C 218
PHE C 255
TRP C 239
VAL C 236
 None
 1.40A 4z69A-2wtkC:
undetectable		 4z69A-2wtkC:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 9 ILE C 177
PHE C 157
THR C 249
LEU C 286
LEU C 290
 None
 1.43A 4ze0A-2wtkC:
undetectable		 4ze0A-2wtkC:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 8 LEU B 373
PHE B 379
PHE B 355
THR B 268
 None
 0.87A 5eseA-2wtkB:
undetectable		 5eseA-2wtkB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 GLY B 416
LEU B 158
VAL B 131
THR B 398
LEU B 417
 None
 1.11A 5hg0A-2wtkB:
undetectable		 5hg0A-2wtkB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 11 LEU C 182
PHE C 219
GLY C 215
ILE C 177
VAL C 243
 None
 1.23A 5hjiA-2wtkC:
undetectable		 5hjiA-2wtkC:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 5 LEU C 101
GLY C 196
ASP C 237
ILE C 177
 None
 0.83A 5ik1A-2wtkC:
undetectable		 5ik1A-2wtkC:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 7 GLY C  56
GLY C  58
SER C  59
GLU C 138
 ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-4.1A)
 0.74A 5izfA-2wtkC:
29.7		 5izfA-2wtkC:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 7 GLY C  56
GLY C  58
SER C  59
LYS C  78
LEU C  80
 ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-3.6A)
None
 1.13A 5izfA-2wtkC:
29.7		 5izfA-2wtkC:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 7 GLY C  56
GLY C  58
SER C  59
GLY C  61
VAL C  63
 ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-3.8A)
ANP  C   2 (-4.2A)
 0.69A 5izjB-2wtkC:
29.8		 5izjB-2wtkC:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 7 GLY C  56
GLY C  58
SER C  59
VAL C  63
LYS C  78
 ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
 0.89A 5izjA-2wtkC:
30.0		 5izjA-2wtkC:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		5 / 7 GLY C  56
GLY C  58
SER C  59
VAL C  63
LYS C  78
 ANP  C   2 (-3.3A)
ANP  C   2 (-3.0A)
None
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
 0.79A 5j5xA-2wtkC:
29.9		 5j5xA-2wtkC:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 VAL B 121
LEU B 124
LEU B 214
GLY B 190
SER B 219
 None
 1.03A 5jvzA-2wtkB:
undetectable		 5jvzA-2wtkB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		5 / 12 VAL B 121
LEU B 124
LEU B 214
GLY B 190
SER B 219
 None
 1.08A 5jvzB-2wtkB:
undetectable		 5jvzB-2wtkB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 11 LEU C  55
GLY C  56
VAL C  63
ALA C  76
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
 0.56A 5lvnA-2wtkC:
31.9		 5lvnA-2wtkC:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 10 LEU C  55
VAL C  63
ALA C  76
MET C 129
TYR C 131
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
None
None
None
 0.69A 5n3hA-2wtkC:
29.9		 5n3hA-2wtkC:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		6 / 12 LEU B  87
GLU B 118
VAL B 131
PHE B 149
GLY B 153
LEU B 202
 None
None
None
ANP  B 432 ( 4.9A)
ANP  B 432 ( 4.2A)
ANP  B 432 ( 4.7A)
 0.88A 5te0A-2wtkB:
24.9		 5te0A-2wtkB:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 5 LEU C  55
VAL C  63
MET C 129
CYH C 132
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
None
ANP  C   2 (-4.5A)
 0.94A 5te0A-2wtkC:
25.7		 5te0A-2wtkC:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		3 / 3 GLY C 270
THR C 249
PRO C 254
 None
 0.63A 5v5zA-2wtkC:
undetectable		 5v5zA-2wtkC:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		6 / 12 LEU C  55
VAL C  63
ALA C  76
LYS C  78
GLU C  98
CYH C 132
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
ANP  C   2 (-4.5A)
 0.76A 5vcyA-2wtkC:
24.6		 5vcyA-2wtkC:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		7 / 12 LEU C  55
VAL C  63
ALA C  76
LYS C  78
CYH C 132
GLU C 138
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
ANP  C   2 (-4.5A)
ANP  C   2 (-4.1A)
None
 0.92A 5y7zA-2wtkC:
25.8		 5y7zA-2wtkC:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		7 / 12 LEU C  55
VAL C  63
ALA C  76
LYS C  78
CYH C 132
GLU C 138
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
ANP  C   2 (-4.5A)
ANP  C   2 (-4.1A)
None
 0.92A 5y7zA-2wtkC:
25.8		 5y7zA-2wtkC:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		7 / 12 LEU C  55
VAL C  63
ALA C  76
LYS C  78
GLU C  98
CYH C 132
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
ANP  C   2 (-4.5A)
None
 0.99A 5y7zA-2wtkC:
25.8		 5y7zA-2wtkC:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		7 / 12 LEU C  55
VAL C  63
ALA C  76
LYS C  78
GLU C  98
CYH C 132
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
ANP  C   2 (-4.5A)
None
 0.99A 5y7zA-2wtkC:
25.8		 5y7zA-2wtkC:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 6 GLN B 358
VAL B 356
ALA B 269
THR B 268
 None
 1.06A 6cduB-2wtkB:
undetectable
6cduC-2wtkB:
undetectable		 6cduB-2wtkB:
22.60
6cduC-2wtkB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_1
()		 2wtk SERINE/THREONINE-PRO
TEIN KINASE 11
(Homo
sapiens) 		4 / 8 LEU C 290
LEU C 252
GLY C 251
ARG C 147
 None
 0.93A 6ce2A-2wtkC:
undetectable		 6ce2A-2wtkC:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 6 ALA B 370
GLY B 266
THR B 268
ILE B 201
 None
 0.87A 6f8cA-2wtkB:
undetectable		 6f8cA-2wtkB:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 5 VAL B 121
PHE B 149
MET B 150
GLY B 153
 None
ANP  B 432 ( 4.9A)
None
ANP  B 432 ( 4.2A)
 0.85A 6hd4A-2wtkB:
21.8		 6hd4A-2wtkB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA
(Homo
sapiens) 		4 / 6 VAL B 121
PHE B 149
MET B 150
GLY B 153
 None
ANP  B 432 ( 4.9A)
None
ANP  B 432 ( 4.2A)
 0.87A 6hd4B-2wtkB:
21.7		 6hd4B-2wtkB:
12.50