SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wtn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		4 / 8 ALA A 237
LEU A 190
LEU A 217
HIS A 104
 None
None
None
GOL  A1249 (-3.8A)
 0.89A 1ereE-2wtnA:
undetectable		 1ereE-2wtnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		4 / 8 ALA A 237
LEU A 190
LEU A 217
HIS A 104
 None
None
None
GOL  A1249 (-3.8A)
 0.88A 1ereF-2wtnA:
undetectable		 1ereF-2wtnA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		5 / 11 LEU A  57
GLY A 108
GLY A 107
VAL A  86
ILE A  28
 None
 1.06A 1sduA-2wtnA:
undetectable		 1sduA-2wtnA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		4 / 5 PRO A 201
ALA A 204
ASP A 197
ASP A 228
 None
 1.17A 2nyuB-2wtnA:
3.6		 2nyuB-2wtnA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		3 / 3 VAL A  87
ASP A  88
GLU A 118
 None
 0.73A 2qeuA-2wtnA:
undetectable		 2qeuA-2wtnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		3 / 3 VAL A  87
ASP A  88
GLU A 118
 None
 0.74A 2qeuC-2wtnA:
undetectable		 2qeuC-2wtnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		5 / 12 ILE A 134
ALA A 138
GLN A 174
LEU A 143
LEU A 113
 None
 1.11A 3dzyA-2wtnA:
undetectable		 3dzyA-2wtnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		5 / 12 VAL A 200
HIS A 225
ASP A 197
GLY A  32
SER A 105
 None
GOL  A1249 ( 4.8A)
None
GOL  A1249 ( 3.3A)
FER  A1250 ( 2.3A)
 0.96A 3sufB-2wtnA:
undetectable		 3sufB-2wtnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		6 / 12 VAL A 200
HIS A 225
ASP A 197
ILE A  42
GLY A 107
SER A 105
 None
GOL  A1249 ( 4.8A)
None
None
None
FER  A1250 ( 2.3A)
 1.40A 3sufB-2wtnA:
undetectable		 3sufB-2wtnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		5 / 11 ALA A  55
LEU A  14
LEU A  93
ILE A   3
ILE A  28
 None
 1.10A 3tqbA-2wtnA:
2.2		 3tqbA-2wtnA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		4 / 7 PRO A 127
VAL A 111
MET A 112
ALA A 115
 None
 0.82A 4lb2A-2wtnA:
undetectable		 4lb2A-2wtnA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		4 / 6 SER A 205
PRO A 127
MET A 112
LEU A 217
 None
 1.44A 5dzka-2wtnA:
3.1
5dzko-2wtnA:
undetectable		 5dzka-2wtnA:
21.79
5dzko-2wtnA:
1.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		5 / 12 GLY A 167
ILE A 134
GLN A 106
LEU A  76
ALA A 173
 GOL  A1251 (-3.6A)
None
None
None
None
 1.02A 5l0zA-2wtnA:
4.1		 5l0zA-2wtnA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		3 / 3 CYH A  24
MET A  16
ASN A  50
 None
 1.22A 5qh8A-2wtnA:
undetectable		 5qh8A-2wtnA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		5 / 10 PRO A 127
MET A 101
ILE A  28
LEU A 125
LEU A 109
 None
 1.32A 5tixB-2wtnA:
2.2		 5tixB-2wtnA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		4 / 8 THR A  34
GLY A  35
GLY A  32
SER A 105
 FER  A1250 (-3.5A)
GOL  A1249 ( 4.0A)
GOL  A1249 ( 3.3A)
FER  A1250 ( 2.3A)
 0.65A 5vw9A-2wtnA:
2.4		 5vw9A-2wtnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2wtn EST1E
(Butyrivibrio
proteoclasticus) 		5 / 12 ASP A 197
LEU A 143
LEU A 144
SER A 105
ALA A 131
 None
None
FER  A1250 ( 4.2A)
FER  A1250 ( 2.3A)
FER  A1250 ( 3.9A)
 1.33A 6n91A-2wtnA:
2.7		 6n91A-2wtnA:
17.81