SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		3 / 3 GLU A  39
ILE A  38
ARG A  28
 None
None
SO4  A1409 ( 4.0A)
 0.85A 1cd2A-2wu0A:
undetectable		 1cd2A-2wu0A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A 271
LEU A 266
ALA A  95
ALA A 289
LEU A 321
 None
 1.41A 1iiuA-2wu0A:
undetectable		 1iiuA-2wu0A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		3 / 3 GLU A  70
GLU A  21
LEU A  16
 None
 0.75A 1v8bA-2wu0A:
undetectable		 1v8bA-2wu0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		3 / 3 GLU A  70
GLU A  21
LEU A  80
 None
 0.74A 1v8bA-2wu0A:
undetectable		 1v8bA-2wu0A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 10 ALA A 105
THR A 104
ALA A 103
VAL A  93
GLY A 111
 None
 0.91A 2f16Y-2wu0A:
undetectable
2f16Z-2wu0A:
undetectable		 2f16Y-2wu0A:
19.67
2f16Z-2wu0A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		3 / 3 THR A 167
ASP A 250
SER A 252
 None
 0.84A 2nxeA-2wu0A:
undetectable		 2nxeA-2wu0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		3 / 3 THR A 167
ASP A 250
SER A 252
 None
 0.82A 2nxeB-2wu0A:
undetectable		 2nxeB-2wu0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 9 LEU A 321
GLU A  21
ILE A 294
GLY A 318
LEU A 287
 None
 1.07A 2qmmA-2wu0A:
undetectable		 2qmmA-2wu0A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A  22
ILE A 315
ALA A 295
THR A 299
ARG A 366
 None
 1.25A 2v0mC-2wu0A:
undetectable		 2v0mC-2wu0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A  22
ILE A 315
ALA A 295
THR A 299
ARG A 366
 None
 1.23A 2v0mD-2wu0A:
undetectable		 2v0mD-2wu0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_A_GLYA73_0
(NONSTRUCTURAL
PROTEIN 1)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		4 / 5 GLN A 367
ALA A 387
GLN A 390
ARG A 391
 None
 1.43A 2z0aA-2wu0A:
undetectable		 2z0aA-2wu0A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		4 / 8 GLU A  21
SER A 320
GLN A 341
VAL A 375
 None
 1.23A 3b9lA-2wu0A:
undetectable		 3b9lA-2wu0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		3 / 3 ASN A 314
MET A 301
PHE A 340
 None
 0.99A 3g4lD-2wu0A:
undetectable		 3g4lD-2wu0A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 11 ASN A 268
LEU A 267
LEU A 323
VAL A 338
ILE A 385
 None
 1.19A 3jw5A-2wu0A:
undetectable		 3jw5A-2wu0A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 11 THR A 104
GLY A  58
VAL A  65
ASP A 110
VAL A  64
 None
 1.05A 3lxiB-2wu0A:
undetectable		 3lxiB-2wu0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		4 / 8 HIS A  59
SER A 219
LEU A 361
ASP A 346
 None
 1.07A 3n2oC-2wu0A:
undetectable
3n2oD-2wu0A:
undetectable		 3n2oC-2wu0A:
21.11
3n2oD-2wu0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		4 / 6 LEU A 271
LEU A 267
LEU A 287
LEU A  22
 None
 1.00A 3q1eA-2wu0A:
undetectable
3q1eC-2wu0A:
undetectable		 3q1eA-2wu0A:
12.63
3q1eC-2wu0A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		4 / 6 LEU A 287
LEU A  22
LEU A 271
LEU A 267
 None
 1.12A 3q1eA-2wu0A:
undetectable
3q1eC-2wu0A:
undetectable		 3q1eA-2wu0A:
12.63
3q1eC-2wu0A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 10 THR A 104
GLY A  58
VAL A  65
ASP A 110
VAL A  64
 None
 1.04A 4c9nB-2wu0A:
undetectable		 4c9nB-2wu0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 10 THR A 104
GLY A  58
VAL A  65
ASP A 110
VAL A  64
 None
 1.05A 4c9pB-2wu0A:
undetectable		 4c9pB-2wu0A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		4 / 5 VAL A 375
ARG A 337
GLU A 324
LEU A  78
 None
 1.42A 4hojA-2wu0A:
undetectable		 4hojA-2wu0A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		3 / 3 LEU A 336
ARG A 337
MET A 360
 None
 0.95A 4m11C-2wu0A:
undetectable		 4m11C-2wu0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A  63
GLY A 344
LEU A 345
ALA A  25
LEU A 216
 None
None
None
SO4  A1408 (-3.2A)
None
 1.04A 5c0oE-2wu0A:
undetectable		 5c0oE-2wu0A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 6 ARG A 100
ASP A  53
ARG A  35
GLY A  33
GLU A  36
 SO4  A1407 ( 3.1A)
None
None
None
None
 1.47A 5cdqA-2wu0A:
undetectable
5cdqC-2wu0A:
undetectable
5cdqD-2wu0A:
undetectable		 5cdqA-2wu0A:
20.97
5cdqC-2wu0A:
20.97
5cdqD-2wu0A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 12 ARG A  76
LEU A  81
VAL A  19
LEU A 286
GLY A  68
 None
 1.17A 5i8fA-2wu0A:
undetectable		 5i8fA-2wu0A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 11 ALA A 105
THR A 104
ALA A 103
VAL A  93
GLY A 111
 None
 0.91A 5lf7K-2wu0A:
undetectable
5lf7L-2wu0A:
undetectable		 5lf7K-2wu0A:
18.53
5lf7L-2wu0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		5 / 11 ALA A 105
THR A 104
ALA A 103
VAL A  93
GLY A 111
 None
 0.91A 5lf7Y-2wu0A:
undetectable
5lf7Z-2wu0A:
undetectable		 5lf7Y-2wu0A:
18.53
5lf7Z-2wu0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		4 / 8 ILE A 238
VAL A 211
THR A 246
TYR A 249
 None
None
None
SO4  A1409 (-4.7A)
 0.92A 6cduG-2wu0A:
undetectable
6cduH-2wu0A:
undetectable		 6cduG-2wu0A:
21.93
6cduH-2wu0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		3 / 3 ARG A 327
GLY A 332
GLU A 333
 None
 0.49A 6fgdA-2wu0A:
undetectable		 6fgdA-2wu0A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		4 / 7 ILE A 184
TRP A  46
GLU A  39
VAL A 206
 None
 1.11A 6j20A-2wu0A:
undetectable		 6j20A-2wu0A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		4 / 7 HIS A 290
ARG A  94
HIS A 121
ASP A 128
 SO4  A1408 (-4.1A)
None
None
None
 1.25A 6mn4E-2wu0A:
undetectable		 6mn4E-2wu0A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wu0 PHYTASE
(Klebsiella
pneumoniae) 		4 / 5 TYR A 339
ARG A 362
THR A 377
LEU A 378
 None
 1.24A 6nknW-2wu0A:
undetectable		 6nknW-2wu0A:
9.09