SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wu5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 PHE A 532
TRP A 553
GLU A 535
 None
 0.88A 1mogA-2wu5A:
undetectable		 1mogA-2wu5A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 TYR A 276
ILE A 295
GLU A 296
ARG A 301
 None
 0.62A 1mrjA-2wu5A:
undetectable		 1mrjA-2wu5A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 2wu5 SUCCINATE
DEHYDROGENASE
CYTOCHROME B556
SUBUNIT
(Escherichia
coli) 		5 / 12 SER C  33
ILE C  36
ILE C  28
TYR C  83
HIS C  91
 None
None
CBE  C1130 (-4.0A)
None
HEM  C 305 (-3.2A)
 1.49A 1ot7A-2wu5C:
1.8		 1ot7A-2wu5C:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 9 VAL A  12
LEU A  35
LEU A 146
GLY A  17
ALA A  18
 None
None
None
FAD  A 601 (-4.2A)
FAD  A 601 (-3.8A)
 1.26A 1pxxB-2wu5A:
undetectable		 1pxxB-2wu5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 10 VAL A  12
LEU A  35
LEU A 146
GLY A  17
ALA A  18
 None
None
None
FAD  A 601 (-4.2A)
FAD  A 601 (-3.8A)
 1.25A 1pxxD-2wu5A:
undetectable		 1pxxD-2wu5A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 6 ARG A 451
TYR A 165
ASP A 221
ASN A 518
 None
FAD  A 601 (-3.5A)
FAD  A 601 (-3.5A)
None
 1.32A 1rjdA-2wu5A:
undetectable		 1rjdA-2wu5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 6 ARG A 451
TYR A 165
ASP A 221
ASN A 518
 None
FAD  A 601 (-3.5A)
FAD  A 601 (-3.5A)
None
 1.30A 1rjdB-2wu5A:
undetectable		 1rjdB-2wu5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 6 ARG A 451
TYR A 165
ASP A 221
ASN A 518
 None
FAD  A 601 (-3.5A)
FAD  A 601 (-3.5A)
None
 1.29A 1rjdC-2wu5A:
undetectable		 1rjdC-2wu5A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 THR A  54
GLY A  51
ASP A 407
HIS A 395
ARG A 286
 None
TEO  A1589 ( 3.1A)
None
None
TEO  A1589 (-2.9A)
 1.18A 1wg8A-2wu5A:
3.2		 1wg8A-2wu5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A 396
GLN A  82
ASP A  81
ASP A  77
MET A 573
 None
 1.15A 1wg8B-2wu5A:
3.3		 1wg8B-2wu5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 11 THR A 362
VAL A 386
GLY A 387
VAL A 394
VAL A 392
 None
None
FAD  A 601 (-3.3A)
None
None
 1.24A 2a1nA-2wu5A:
undetectable		 2a1nA-2wu5A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 ASP A 287
GLY A 120
PHE A 119
THR A 254
 None
None
None
TEO  A1589 (-3.8A)
 0.96A 2aouA-2wu5A:
undetectable		 2aouA-2wu5A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A  24
LEU A 145
GLU A  98
LEU A  99
ARG A  21
 None
 1.25A 2bxfB-2wu5A:
2.0		 2bxfB-2wu5A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A 408
THR A 362
VAL A 392
GLY A 204
LEU A 169
 FAD  A 601 (-4.0A)
None
None
None
None
 1.08A 2cbrA-2wu5A:
undetectable		 2cbrA-2wu5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 10 THR A 362
VAL A 386
GLY A 387
VAL A 394
VAL A 392
 None
None
FAD  A 601 (-3.3A)
None
None
 1.38A 2cp4A-2wu5A:
undetectable		 2cp4A-2wu5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 SER A 292
LEU A 400
ASP A  77
GLY A 538
TYR A  78
 None
 1.35A 2kceA-2wu5A:
undetectable		 2kceA-2wu5A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 11 LEU A 200
ILE A  13
GLY A  14
GLY A  19
LEU A 383
 None
FAD  A 601 ( 4.9A)
FAD  A 601 (-3.1A)
None
None
 1.01A 2qmmA-2wu5A:
undetectable
2qmmB-2wu5A:
undetectable		 2qmmA-2wu5A:
16.52
2qmmB-2wu5A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 MET A 357
SER A 393
TYR A 355
HIS A 395
 None
None
FAD  A 601 (-4.3A)
None
 1.33A 2v0gA-2wu5A:
undetectable		 2v0gA-2wu5A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A 146
GLY A 142
SER A  48
ALA A  49
GLY A  19
 None
None
None
FAD  A 601 (-3.3A)
None
 0.96A 2vmyB-2wu5A:
undetectable		 2vmyB-2wu5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A 146
GLY A 142
SER A  48
ALA A  49
GLY A  19
 None
None
None
FAD  A 601 (-3.3A)
None
 1.01A 2vmyA-2wu5A:
undetectable		 2vmyA-2wu5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A 382
LEU A 383
LEU A 560
ALA A 176
VAL A 177
 None
 0.80A 3av6A-2wu5A:
undetectable		 3av6A-2wu5A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 LEU A 441
SER A 440
VAL A 170
ALA A 166
 None
None
None
FAD  A 601 (-3.2A)
 1.01A 3ax9A-2wu5A:
undetectable		 3ax9A-2wu5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wu5 SUCCINATE
DEHYDROGENASE
CYTOCHROME B556
SUBUNIT
(Escherichia
coli) 		5 / 12 VAL C 128
GLY C 125
ALA C 124
SER C 121
LEU C 120
 None
 0.97A 3hs6A-2wu5C:
undetectable		 3hs6A-2wu5C:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A 169
GLY A 222
GLY A 224
LEU A 519
ALA A 166
 None
None
None
None
FAD  A 601 (-3.2A)
 1.03A 3i5uA-2wu5A:
undetectable		 3i5uA-2wu5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A 169
GLY A 230
LEU A 560
PRO A 561
ALA A 368
 None
 1.22A 3i5uA-2wu5A:
undetectable		 3i5uA-2wu5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A 169
GLY A 222
GLY A 224
LEU A 519
ALA A 166
 None
None
None
None
FAD  A 601 (-3.2A)
 1.03A 3i5uB-2wu5A:
undetectable		 3i5uB-2wu5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A  21
GLU A  94
TYR A  87
 None
 0.75A 3k37B-2wu5A:
undetectable		 3k37B-2wu5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 10 ASP A 221
ILE A 389
VAL A 223
MET A 356
GLY A 206
 FAD  A 601 (-3.5A)
None
None
None
None
 1.00A 3ogqA-2wu5A:
undetectable		 3ogqA-2wu5A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 11 ARG A 258
LEU A 313
ASP A 341
VAL A 349
ILE A 347
 None
 1.12A 3oxxB-2wu5A:
undetectable		 3oxxB-2wu5A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 THR A 134
GLY A 401
GLY A 120
ARG A 258
LEU A 315
 None
TEO  A1589 (-3.4A)
None
None
None
 1.20A 3t7vA-2wu5A:
undetectable		 3t7vA-2wu5A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 PHE A 193
GLY A 179
PHE A   8
ARG A   6
PRO A   4
 None
 1.20A 4bvaA-2wu5A:
2.8		 4bvaA-2wu5A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_B_T3B1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 PHE A 193
GLY A 179
PHE A   8
ARG A   6
PRO A   4
 None
 1.18A 4bvaB-2wu5A:
2.9		 4bvaB-2wu5A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 7 GLY A 204
GLY A 206
MET A 356
CYH A 353
 None
 0.69A 4c5nA-2wu5A:
undetectable		 4c5nA-2wu5A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 GLY A 204
GLY A 206
MET A 356
CYH A 353
 None
 0.72A 4c5nC-2wu5A:
undetectable		 4c5nC-2wu5A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 11 SER A 292
LEU A 400
ASP A  77
GLY A 538
TYR A  78
 None
 1.22A 4fogC-2wu5A:
undetectable		 4fogC-2wu5A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 11 SER A 292
LEU A 400
ASP A  77
GLY A 538
TYR A  78
 None
 1.31A 4foxC-2wu5A:
undetectable		 4foxC-2wu5A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 7 ILE A  26
ALA A  10
VAL A  11
ALA A 415
 None
 0.61A 4g77A-2wu5A:
undetectable		 4g77A-2wu5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 7 ILE A  26
LEU A 419
PHE A 384
GLY A 382
 None
 0.97A 4hajA-2wu5A:
undetectable		 4hajA-2wu5A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 7 ARG A 258
SER A 472
VAL A 289
MET A 294
 None
 1.31A 4kmmA-2wu5A:
undetectable		 4kmmA-2wu5A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 ALA A  34
GLY A  14
LEU A 200
TYR A 165
GLU A 515
 None
FAD  A 601 (-3.1A)
None
FAD  A 601 (-3.5A)
None
 1.07A 4lg1A-2wu5A:
undetectable		 4lg1A-2wu5A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 ALA A  34
GLY A  14
LEU A 200
TYR A 165
GLU A 515
 None
FAD  A 601 (-3.1A)
None
FAD  A 601 (-3.5A)
None
 1.07A 4lg1B-2wu5A:
2.7		 4lg1B-2wu5A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 VAL A 190
LEU A 183
LEU A 167
ASN A 445
 None
 0.86A 4lzrA-2wu5A:
undetectable		 4lzrA-2wu5A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 5 TYR A 355
THR A 148
LEU A 104
THR A  54
 FAD  A 601 (-4.3A)
None
None
None
 1.46A 4mbsB-2wu5A:
undetectable		 4mbsB-2wu5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 HIS A 242
THR A 244
GLU A 255
GLY A 120
GLY A  52
 TEO  A1589 (-3.9A)
None
None
None
FAD  A 601 (-4.1A)
 1.40A 4uinH-2wu5A:
undetectable
4uinL-2wu5A:
undetectable		 4uinH-2wu5A:
16.95
4uinL-2wu5A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 SER A  37
GLY A  14
ALA A 205
GLY A 203
 FAD  A 601 (-2.7A)
FAD  A 601 (-3.1A)
None
FAD  A 601 (-3.0A)
 0.91A 5albL-2wu5A:
undetectable		 5albL-2wu5A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 ALA A  23
GLY A  14
GLY A  19
GLY A  17
LEU A  36
 None
FAD  A 601 (-3.1A)
None
FAD  A 601 (-4.2A)
None
 1.06A 5c0oH-2wu5A:
3.3		 5c0oH-2wu5A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 9 THR A 362
VAL A 386
GLY A 387
VAL A 394
VAL A 392
 None
None
FAD  A 601 (-3.3A)
None
None
 1.36A 5cp4A-2wu5A:
undetectable		 5cp4A-2wu5A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 7 GLU A 388
SER A 404
ARG A 399
GLY A 402
 FAD  A 601 ( 3.3A)
FAD  A 601 (-2.9A)
TEO  A1589 (-2.9A)
FAD  A 601 ( 3.2A)
 0.89A 5e26A-2wu5A:
undetectable
5e26B-2wu5A:
undetectable		 5e26A-2wu5A:
21.22
5e26B-2wu5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 7 ALA A  49
GLU A 388
SER A 404
ARG A 399
GLY A 402
 FAD  A 601 (-3.3A)
FAD  A 601 ( 3.3A)
FAD  A 601 (-2.9A)
TEO  A1589 (-2.9A)
FAD  A 601 ( 3.2A)
 1.40A 5e26A-2wu5A:
undetectable
5e26B-2wu5A:
undetectable		 5e26A-2wu5A:
21.22
5e26B-2wu5A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 8 TYR A 355
LEU A 408
LEU A 405
THR A 134
 FAD  A 601 (-4.3A)
FAD  A 601 (-4.0A)
FAD  A 601 (-3.6A)
None
 1.13A 5hs6A-2wu5A:
undetectable		 5hs6A-2wu5A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 5 GLU A 388
SER A 404
ARG A 399
GLY A 402
 FAD  A 601 ( 3.3A)
FAD  A 601 (-2.9A)
TEO  A1589 (-2.9A)
FAD  A 601 ( 3.2A)
 1.03A 5kprA-2wu5A:
undetectable		 5kprA-2wu5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 11 ARG A  21
LEU A  99
ALA A 135
GLY A 402
ILE A  96
 None
None
None
FAD  A 601 ( 3.2A)
None
 1.28A 5kr2B-2wu5A:
undetectable		 5kr2B-2wu5A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 SER A  44
THR A  46
ALA A 201
GLY A  19
ALA A  15
 FAD  A 601 (-2.6A)
FAD  A 601 (-3.2A)
None
None
FAD  A 601 (-4.1A)
 1.32A 5l5zH-2wu5A:
undetectable
5l5zI-2wu5A:
undetectable		 5l5zH-2wu5A:
19.15
5l5zI-2wu5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 SER A  44
THR A  46
ALA A 201
GLY A  19
ALA A  15
 FAD  A 601 (-2.6A)
FAD  A 601 (-3.2A)
None
None
FAD  A 601 (-4.1A)
 1.32A 5l5zV-2wu5A:
undetectable
5l5zW-2wu5A:
undetectable		 5l5zV-2wu5A:
19.15
5l5zW-2wu5A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A 366
VAL A 379
ALA A 385
ILE A  13
ALA A 201
 None
None
None
FAD  A 601 ( 4.9A)
None
 1.01A 5n0tB-2wu5A:
undetectable		 5n0tB-2wu5A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2wu5 SUCCINATE
DEHYDROGENASE
CYTOCHROME B556
SUBUNIT
(Escherichia
coli) 		4 / 7 GLY C 125
LEU C  81
THR C  79
ALA C  82
 None
 0.79A 5o96C-2wu5C:
undetectable		 5o96C-2wu5C:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 11 LEU A 200
ILE A  13
GLY A  14
GLY A  19
LEU A 383
 None
FAD  A 601 ( 4.9A)
FAD  A 601 (-3.1A)
None
None
 0.94A 5twjD-2wu5A:
undetectable		 5twjD-2wu5A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 ALA A 415
GLY A  14
ALA A  15
LEU A 146
LEU A 149
 None
FAD  A 601 (-3.1A)
FAD  A 601 (-4.1A)
None
None
 1.08A 5xxiA-2wu5A:
undetectable		 5xxiA-2wu5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 6 TYR A 276
ILE A 295
GLU A 296
ARG A 301
 None
 0.60A 5z3jA-2wu5A:
undetectable		 5z3jA-2wu5A:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		3 / 3 HIS A 242
HIS A 354
ARG A 399
 TEO  A1589 (-3.9A)
TEO  A1589 ( 3.8A)
TEO  A1589 (-2.9A)
 0.49A 6b58A-2wu5A:
46.1		 6b58A-2wu5A:
42.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 TYR A 150
LEU A 145
GLY A 142
SER A  37
VAL A  39
 None
None
None
FAD  A 601 (-2.7A)
FAD  A 601 (-4.1A)
 1.37A 6bxlB-2wu5A:
3.3		 6bxlB-2wu5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		4 / 7 ASP A 168
ALA A 166
GLU A 515
LEU A 444
 None
FAD  A 601 (-3.2A)
None
None
 1.05A 6ci6A-2wu5A:
undetectable		 6ci6A-2wu5A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A 331
VAL A 253
GLY A 259
LEU A 252
ILE A 330
 None
None
None
FAD  A 601 ( 4.0A)
None
 0.98A 6dgxB-2wu5A:
undetectable		 6dgxB-2wu5A:
17.43