SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 269
VAL A 245
LEU A 296
LEU A 103
 None
 0.89A 1cqpA-2wu8A:
undetectable
1cqpB-2wu8A:
2.7		 1cqpA-2wu8A:
16.83
1cqpB-2wu8A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 203
LEU A 205
GLY A 143
LEU A 233
 None
 0.90A 1gtiD-2wu8A:
undetectable		 1gtiD-2wu8A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 160
VAL A 245
SER A 246
ASN A 248
 None
 1.24A 1hwkC-2wu8A:
undetectable		 1hwkC-2wu8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 SER A 160
VAL A 245
SER A 246
ASN A 248
 None
 1.23A 1hwkD-2wu8A:
undetectable		 1hwkD-2wu8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A 241
LEU A 233
LEU A 205
TRP A 141
 None
 1.07A 1i7zA-2wu8A:
undetectable		 1i7zA-2wu8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 11 GLU A  78
ARG A  73
LEU A 311
GLU A 312
ALA A 309
 None
 1.02A 1mjqA-2wu8A:
undetectable
1mjqB-2wu8A:
undetectable		 1mjqA-2wu8A:
10.96
1mjqB-2wu8A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 309
GLU A  78
ARG A  73
LEU A 311
GLU A 312
 None
 1.08A 1mjqC-2wu8A:
undetectable
1mjqD-2wu8A:
undetectable		 1mjqC-2wu8A:
10.96
1mjqD-2wu8A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 309
GLU A  78
ARG A  73
LEU A 311
GLU A 312
 None
 1.08A 1mjqI-2wu8A:
undetectable
1mjqJ-2wu8A:
undetectable		 1mjqI-2wu8A:
10.96
1mjqJ-2wu8A:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.86A 1rxcB-2wu8A:
undetectable		 1rxcB-2wu8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.91A 1rxcC-2wu8A:
undetectable		 1rxcC-2wu8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.91A 1rxcD-2wu8A:
undetectable		 1rxcD-2wu8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.93A 1rxcE-2wu8A:
undetectable		 1rxcE-2wu8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.89A 1rxcF-2wu8A:
2.2		 1rxcF-2wu8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.93A 1rxcI-2wu8A:
undetectable		 1rxcI-2wu8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.85A 1rxcK-2wu8A:
undetectable		 1rxcK-2wu8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.89A 1rxcL-2wu8A:
undetectable		 1rxcL-2wu8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  46
LEU A  44
HIS A  58
THR A 470
 None
 1.07A 2f78A-2wu8A:
undetectable		 2f78A-2wu8A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 478
LEU A  51
LEU A 485
ILE A 301
GLY A  49
 None
 0.89A 2ouzA-2wu8A:
undetectable		 2ouzA-2wu8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 4 ALA A 291
VAL A 286
PHE A 292
THR A 133
 None
 1.04A 2pkkA-2wu8A:
3.8		 2pkkA-2wu8A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 6 PRO A 201
ALA A 232
LEU A 229
ALA A 237
 None
 0.97A 2vcvK-2wu8A:
undetectable		 2vcvK-2wu8A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 493
PHE A 494
THR A  92
ASN A  91
VAL A  98
 None
 1.19A 2x2iA-2wu8A:
undetectable		 2x2iA-2wu8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 493
PHE A 494
THR A  92
ASN A  91
VAL A  98
 None
 1.19A 2x2iC-2wu8A:
2.0		 2x2iC-2wu8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  22
GLY A  26
ASN A  27
ARG A  59
 None
 1.26A 3ccfA-2wu8A:
undetectable		 3ccfA-2wu8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A 480
TYR A 174
LEU A 171
ILE A 486
PHE A 408
 None
 1.45A 3qt0A-2wu8A:
undetectable		 3qt0A-2wu8A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A  13
THR A  12
LEU A  71
 None
 0.73A 3ttrA-2wu8A:
undetectable		 3ttrA-2wu8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 100
SER A 358
GLY A 497
SER A 504
VAL A 498
 None
 1.15A 4danA-2wu8A:
undetectable
4danB-2wu8A:
undetectable		 4danA-2wu8A:
19.17
4danB-2wu8A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.86A 4e1vA-2wu8A:
undetectable		 4e1vA-2wu8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.86A 4e1vB-2wu8A:
undetectable		 4e1vB-2wu8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.87A 4e1vC-2wu8A:
undetectable		 4e1vC-2wu8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.91A 4e1vD-2wu8A:
undetectable		 4e1vD-2wu8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.90A 4e1vE-2wu8A:
undetectable		 4e1vE-2wu8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.89A 4e1vG-2wu8A:
undetectable		 4e1vG-2wu8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 GLN A 353
ILE A 279
VAL A 275
PRO A 164
 None
 0.88A 4e1vH-2wu8A:
undetectable		 4e1vH-2wu8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 134
ARG A 137
ASP A 127
 None
 0.87A 4fp9A-2wu8A:
undetectable		 4fp9A-2wu8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 134
ARG A 137
ASP A 127
 None
 0.78A 4fp9C-2wu8A:
undetectable		 4fp9C-2wu8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 134
ARG A 137
ASP A 127
 None
 0.75A 4fp9F-2wu8A:
undetectable		 4fp9F-2wu8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 TRP A 141
GLY A 143
PHE A 242
ILE A 257
ASN A 261
 None
 1.19A 4rtsA-2wu8A:
undetectable		 4rtsA-2wu8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 5 GLY A 550
GLY A 553
GLU A 555
 None
 0.49A 4z2eA-2wu8A:
undetectable
4z2eD-2wu8A:
2.3		 4z2eA-2wu8A:
22.20
4z2eD-2wu8A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 170
ASP A 276
ARG A 104
GLY A 298
 None
 0.80A 5bs8A-2wu8A:
undetectable
5bs8C-2wu8A:
undetectable
5bs8D-2wu8A:
3.1		 5bs8A-2wu8A:
24.22
5bs8C-2wu8A:
24.22
5bs8D-2wu8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 170
ASP A 276
ARG A 104
GLY A 298
 None
 0.85A 5bs8A-2wu8A:
undetectable
5bs8B-2wu8A:
2.1
5bs8C-2wu8A:
undetectable		 5bs8A-2wu8A:
24.22
5bs8B-2wu8A:
19.21
5bs8C-2wu8A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 170
ASP A 276
ARG A 104
GLY A 298
 None
 0.87A 5btdA-2wu8A:
undetectable
5btdB-2wu8A:
2.0
5btdC-2wu8A:
undetectable		 5btdA-2wu8A:
24.22
5btdB-2wu8A:
19.21
5btdC-2wu8A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 170
ASP A 276
ARG A 104
GLY A 298
 None
 0.82A 5btdA-2wu8A:
undetectable
5btdC-2wu8A:
undetectable
5btdD-2wu8A:
2.5		 5btdA-2wu8A:
24.22
5btdC-2wu8A:
24.22
5btdD-2wu8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 170
ASP A 276
ARG A 104
GLY A 298
 None
 0.93A 5btgA-2wu8A:
undetectable
5btgC-2wu8A:
undetectable
5btgD-2wu8A:
2.5		 5btgA-2wu8A:
24.22
5btgC-2wu8A:
24.22
5btgD-2wu8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 486
ALA A 487
GLY A 280
PHE A 295
VAL A 167
 None
 0.96A 5i73A-2wu8A:
2.2		 5i73A-2wu8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 270
GLY A 271
GLN A 507
 None
 0.44A 5imsA-2wu8A:
2.7		 5imsA-2wu8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 477
GLY A 163
ALA A 170
LEU A 344
GLY A 280
 None
 0.96A 5kb5A-2wu8A:
3.1		 5kb5A-2wu8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 THR A 285
ASN A 154
PHE A 183
PRO A 164
 None
 1.13A 5v4vA-2wu8A:
undetectable		 5v4vA-2wu8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 8 THR A 285
ASN A 154
PHE A 183
PRO A 164
 None
 1.15A 5v4vB-2wu8A:
undetectable		 5v4vB-2wu8A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 159
GLY A 163
GLU A 490
ASP A 404
VAL A 337
 None
 0.93A 5wz1A-2wu8A:
undetectable		 5wz1A-2wu8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 159
GLY A 163
GLU A 490
ASP A 404
VAL A 337
 None
 0.93A 5wz1C-2wu8A:
undetectable		 5wz1C-2wu8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 159
GLY A 163
GLU A 490
ASP A 404
VAL A 337
 None
 0.93A 5wz1D-2wu8A:
undetectable		 5wz1D-2wu8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 159
GLY A 163
GLU A 490
ASP A 404
VAL A 337
 None
 0.94A 5wz1E-2wu8A:
undetectable		 5wz1E-2wu8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 159
GLY A 163
GLU A 490
ASP A 404
VAL A 337
 None
 0.94A 5wz1F-2wu8A:
undetectable		 5wz1F-2wu8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 159
GLY A 163
GLU A 490
ASP A 404
VAL A 337
 None
 0.94A 5wz1G-2wu8A:
undetectable		 5wz1G-2wu8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 159
GLY A 163
GLU A 490
ASP A 404
VAL A 337
 None
 0.92A 5wz1H-2wu8A:
undetectable		 5wz1H-2wu8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 MET A 284
ASP A 134
ARG A 107
 None
 1.22A 5z6kA-2wu8A:
undetectable		 5z6kA-2wu8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 162
THR A 218
ASN A 221
 None
 0.72A 6baaE-2wu8A:
0.1		 6baaE-2wu8A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 162
THR A 218
ASN A 221
 None
 0.72A 6baaF-2wu8A:
0.1		 6baaF-2wu8A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 162
THR A 218
ASN A 221
 None
 0.73A 6baaG-2wu8A:
undetectable		 6baaG-2wu8A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 162
THR A 218
ASN A 221
 None
 0.73A 6baaH-2wu8A:
0.6		 6baaH-2wu8A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2wu8 GLUCOSE-6-PHOSPHATE
ISOMERASE
(Mycobacterium
tuberculosis) 		4 / 6 SER A 160
ALA A 278
SER A 277
ALA A 209
 None
 0.81A 6bocA-2wu8A:
undetectable
6bocB-2wu8A:
undetectable
6bocC-2wu8A:
undetectable
6bocD-2wu8A:
undetectable		 6bocA-2wu8A:
4.01
6bocB-2wu8A:
4.01
6bocC-2wu8A:
4.01
6bocD-2wu8A:
4.01