SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wua'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 VAL A 420
VAL A  50
ILE A 150
TYR A 155
LEU A 140
 None
 1.03A 1fm4A-2wuaA:
undetectable		 1fm4A-2wuaA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 GLY A 162
GLY A 397
GLY A 139
ALA A 142
ASN A 359
 None
 1.07A 2dpmA-2wuaA:
undetectable		 2dpmA-2wuaA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 11 GLY A 397
SER A 138
THR A 396
HIS A 391
PHE A 362
 None
 1.38A 2hmaA-2wuaA:
undetectable		 2hmaA-2wuaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 GLY A 390
SER A 290
ALA A 386
ASN A 359
GLY A 139
 None
 1.12A 2vmyB-2wuaA:
undetectable		 2vmyB-2wuaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 LEU A 301
VAL A  50
ASP A  97
VAL A 129
TYR A 155
 None
 1.48A 2y00A-2wuaA:
undetectable		 2y00A-2wuaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 LEU A 301
VAL A  50
ASP A  97
VAL A 129
TYR A 155
 None
 1.47A 2y00B-2wuaA:
undetectable		 2y00B-2wuaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 LEU A 301
VAL A  50
ASP A  97
VAL A 129
TYR A 155
 None
 1.44A 2y01B-2wuaA:
undetectable		 2y01B-2wuaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		4 / 4 GLY A 394
GLY A 139
GLY A 397
GLY A 162
 None
 0.67A 3bogC-2wuaA:
undetectable		 3bogC-2wuaA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		4 / 7 LEU A  77
LEU A 163
SER A 102
THR A 131
 None
 1.00A 3cfqA-2wuaA:
undetectable
3cfqB-2wuaA:
undetectable		 3cfqA-2wuaA:
14.29
3cfqB-2wuaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 VAL A  80
LEU A 301
ILE A  98
GLY A 160
ALA A 161
 None
 1.04A 3n8zB-2wuaA:
undetectable		 3n8zB-2wuaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		4 / 7 LEU A  77
LEU A 163
SER A 102
THR A 131
 None
 1.03A 3ozkB-2wuaA:
undetectable		 3ozkB-2wuaA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 GLN A 291
GLY A 385
SER A 219
ALA A 224
ALA A 226
 None
 1.12A 3sueB-2wuaA:
undetectable		 3sueB-2wuaA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		4 / 7 LEU A  77
LEU A 163
SER A 102
THR A 131
 None
 0.98A 4d7bA-2wuaA:
undetectable		 4d7bA-2wuaA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 10 ASN A 381
GLU A 360
ASP A 259
GLU A 235
GLY A 397
 None
 1.44A 4evyA-2wuaA:
0.0
4evyB-2wuaA:
0.0		 4evyA-2wuaA:
17.98
4evyB-2wuaA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		4 / 6 LEU A  77
LEU A 163
SER A 102
THR A 131
 None
 1.03A 4ikiB-2wuaA:
undetectable		 4ikiB-2wuaA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		4 / 7 LEU A  77
LEU A 163
SER A 102
THR A 131
 None
 1.04A 4ikjA-2wuaA:
undetectable
4ikjB-2wuaA:
undetectable		 4ikjA-2wuaA:
14.75
4ikjB-2wuaA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		4 / 8 LEU A  77
LEU A 163
SER A 102
THR A 131
 None
 0.98A 4ikjA-2wuaA:
undetectable
4ikjB-2wuaA:
undetectable		 4ikjA-2wuaA:
14.75
4ikjB-2wuaA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		4 / 8 LEU A  77
LEU A 163
SER A 102
THR A 131
 None
 0.98A 4ikkA-2wuaA:
undetectable
4ikkB-2wuaA:
undetectable		 4ikkA-2wuaA:
14.75
4ikkB-2wuaA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		4 / 7 LEU A  77
LEU A 163
SER A 102
THR A 131
 None
 1.00A 4ikkA-2wuaA:
undetectable
4ikkB-2wuaA:
undetectable		 4ikkA-2wuaA:
14.75
4ikkB-2wuaA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		4 / 7 LEU A  77
LEU A 163
SER A 102
THR A 131
 None
 1.01A 4iklA-2wuaA:
undetectable
4iklB-2wuaA:
undetectable		 4iklA-2wuaA:
14.75
4iklB-2wuaA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 VAL A 277
LEU A 271
GLY A 287
ALA A 286
SER A 289
 None
 1.10A 4otyA-2wuaA:
undetectable		 4otyA-2wuaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 9 ALA A  55
ILE A  98
GLY A 162
ALA A 398
VAL A 146
 None
 1.22A 4r1zA-2wuaA:
undetectable		 4r1zA-2wuaA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 TYR A  56
VAL A  80
LEU A 301
GLY A 160
ALA A 161
 None
 1.12A 4rrxB-2wuaA:
undetectable		 4rrxB-2wuaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 8 VAL A 277
LEU A 271
GLY A 287
ALA A 286
SER A 289
 None
 1.18A 5f1aA-2wuaA:
undetectable		 5f1aA-2wuaA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 12 SER A 219
PHE A 232
ALA A 386
THR A 396
GLU A 407
 None
 1.21A 5vcgA-2wuaA:
undetectable		 5vcgA-2wuaA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2wua ACETOACETYL COA
THIOLASE
(Helianthus
annuus) 		5 / 11 GLY A 162
ALA A 398
ALA A 298
ILE A 159
VAL A 100
 None
 1.17A 5yk2A-2wuaA:
undetectable		 5yk2A-2wuaA:
23.31