SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wui'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2wui TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 194
GLU A 189
LEU A  86
PHE A 192
LEU A  93
 None
 1.19A 1jomA-2wuiA:
undetectable		 1jomA-2wuiA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 2wui TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 8 MET A  62
ALA A  61
LEU A  60
TYR A  49
 None
 0.94A 3cldB-2wuiA:
undetectable		 3cldB-2wuiA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wui TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 206
LEU A 154
ARG A 200
 None
 0.71A 3hcnB-2wuiA:
undetectable		 3hcnB-2wuiA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 2wui TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 5 LEU A 196
SER A 198
LEU A 166
LEU A  85
 None
 1.33A 4n09D-2wuiA:
undetectable		 4n09D-2wuiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 2wui TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  17
ALA A  19
ALA A  20
THR A  32
 None
 0.81A 6a7jA-2wuiA:
undetectable		 6a7jA-2wuiA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2wui TRANSCRIPTIONAL
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 168
ALA A 188
LEU A 174
ALA A 175
LEU A 180
 None
 0.97A 6bq4A-2wuiA:
undetectable		 6bq4A-2wuiA:
17.73