SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA
(Bacillus
subtilis) 		4 / 8 THR A  87
ASP A  92
TYR A 238
SER A  95
 None
 1.18A 2xz5C-2wv0A:
undetectable
2xz5D-2wv0A:
undetectable		 2xz5C-2wv0A:
19.92
2xz5D-2wv0A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA
(Bacillus
subtilis) 		5 / 12 PHE A  44
ALA A  54
LEU A  55
LEU A  34
ILE A  23
 None
 0.95A 4g1bA-2wv0A:
undetectable		 4g1bA-2wv0A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA
(Bacillus
subtilis) 		4 / 6 GLU A 222
ARG A 135
GLU A 145
SER A 147
 None
SO4  A1244 (-3.3A)
SO4  A1244 ( 4.4A)
None
 0.97A 4kr3A-2wv0A:
undetectable		 4kr3A-2wv0A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA
(Bacillus
subtilis) 		5 / 9 PRO A 205
VAL A 206
ALA A 189
GLY A 199
GLY A 203
 None
 1.15A 4mmbA-2wv0A:
0.8		 4mmbA-2wv0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA
(Bacillus
subtilis) 		4 / 6 ARG A 211
GLU A 222
PHE A 221
GLU A  91
 None
 1.40A 5h4dA-2wv0A:
undetectable		 5h4dA-2wv0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA
(Bacillus
subtilis) 		3 / 3 ALA A  54
ASN A  57
LEU A  58
 None
 0.48A 5i1nC-2wv0A:
undetectable		 5i1nC-2wv0A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA
(Bacillus
subtilis) 		5 / 12 GLN A 163
GLY A 101
ALA A 143
VAL A 227
SER A 226
 None
 0.92A 6c2mC-2wv0A:
undetectable		 6c2mC-2wv0A:
16.09