SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wv3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2wv3 NEUROPLASTIN
(Rattus
norvegicus) 		4 / 6 LEU A 186
ASP A 165
GLU A 102
ARG A 143
 None
 1.06A 1mt1A-2wv3A:
undetectable
1mt1F-2wv3A:
undetectable		 1mt1A-2wv3A:
15.08
1mt1F-2wv3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 2wv3 NEUROPLASTIN
(Rattus
norvegicus) 		4 / 5 GLU A 102
ARG A 143
LEU A 186
ASP A 165
 None
 0.99A 1n13B-2wv3A:
undetectable
1n13C-2wv3A:
undetectable		 1n13B-2wv3A:
19.58
1n13C-2wv3A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2wv3 NEUROPLASTIN
(Rattus
norvegicus) 		4 / 7 LEU A 186
ASP A 165
GLU A 102
ARG A 143
 None
 1.01A 1n13I-2wv3A:
undetectable
1n13L-2wv3A:
undetectable		 1n13I-2wv3A:
15.08
1n13L-2wv3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2wv3 NEUROPLASTIN
(Rattus
norvegicus) 		4 / 7 LEU A 186
ASP A 165
GLU A 102
ARG A 143
 None
 1.02A 2qqdA-2wv3A:
undetectable
2qqdE-2wv3A:
undetectable		 2qqdA-2wv3A:
17.61
2qqdE-2wv3A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 2wv3 NEUROPLASTIN
(Rattus
norvegicus) 		5 / 12 LEU A  46
THR A  47
THR A  22
ASN A  61
ILE A  60
 None
 1.09A 3a35A-2wv3A:
undetectable		 3a35A-2wv3A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 2wv3 NEUROPLASTIN
(Rattus
norvegicus) 		5 / 12 LEU A  46
THR A  47
THR A  22
ASN A  61
ILE A  60
 None
 1.07A 3a35B-2wv3A:
undetectable		 3a35B-2wv3A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 2wv3 NEUROPLASTIN
(Rattus
norvegicus) 		4 / 4 GLY A 118
ASP A  94
GLY A  97
THR A 153
 None
 1.08A 3k4vC-2wv3A:
undetectable		 3k4vC-2wv3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2wv3 NEUROPLASTIN
(Rattus
norvegicus) 		3 / 3 THR A  28
SER A  29
ARG A   5
 None
 0.53A 3phnA-2wv3A:
undetectable		 3phnA-2wv3A:
17.55