SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
3 / 3 GLU A  74
ASN A  71
TRP A  69
None
1.07A 1r15F-2wv9A:
undetectable
1r15F-2wv9A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
5 / 12 ILE A 424
GLY A 476
VAL A 336
SER A 337
GLU A 472
None
1.26A 1sg9A-2wv9A:
2.3
1sg9A-2wv9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_N_CHDN1604_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
5 / 11 ARG A 458
GLY A 460
GLY A 415
GLU A 286
THR A 316
None
1.14A 2eimG-2wv9A:
0.0
2eimN-2wv9A:
0.3
2eimO-2wv9A:
0.0
2eimG-2wv9A:
8.64
2eimN-2wv9A:
20.84
2eimO-2wv9A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
5 / 12 THR A 267
VAL A 545
ALA A 548
VAL A 601
VAL A 442
None
1.31A 2nniA-2wv9A:
undetectable
2nniA-2wv9A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
3 / 3 LEU A 501
PRO A 502
LEU A 505
None
0.54A 2po7B-2wv9A:
4.2
2po7B-2wv9A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
5 / 12 PHE A 614
ALA A 541
ALA A 548
CYH A 564
ARG A 561
None
1.13A 2qm9A-2wv9A:
undetectable
2qm9A-2wv9A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
4 / 7 TRP A 403
TYR A 395
ILE A 384
SER A 412
None
1.00A 2xz5A-2wv9A:
undetectable
2xz5B-2wv9A:
undetectable
2xz5A-2wv9A:
17.42
2xz5B-2wv9A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
4 / 7 ILE A 384
SER A 412
TRP A 403
TYR A 395
None
0.99A 2xz5D-2wv9A:
undetectable
2xz5E-2wv9A:
undetectable
2xz5D-2wv9A:
17.42
2xz5E-2wv9A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
3 / 3 LEU A 501
PRO A 502
LEU A 505
None
0.52A 3hcrA-2wv9A:
3.7
3hcrA-2wv9A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
4 / 7 THR A 408
VAL A 423
ASP A 425
VAL A 360
None
1.01A 4cp4A-2wv9A:
undetectable
4cp4A-2wv9A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
5 / 9 ALA A  56
ILE A  58
ALA A  36
ALA A  27
ILE A  25
None
1.05A 4lbgB-2wv9A:
undetectable
4lbgB-2wv9A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
4 / 6 LEU A 205
GLU A 286
VAL A 227
ALA A 230
None
1.18A 4nkvC-2wv9A:
undetectable
4nkvC-2wv9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
4 / 7 GLU A 177
ILE A 313
LEU A 236
ILE A 204
None
0.87A 4xumA-2wv9A:
undetectable
4xumA-2wv9A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
3 / 3 THR A 318
THR A 316
PHE A 289
None
0.84A 5cxvA-2wv9A:
undetectable
5cxvA-2wv9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)
2wv9 FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT, FLAVIVIRIN
PROTEASE NS3
CATALYTIC SUBUNIT

(Murray
Valley
encephalitis
virus)
5 / 12 TYR A 179
VAL A 228
THR A 225
LEU A 194
VAL A 283
None
1.03A 6a93B-2wv9A:
undetectable
6a93B-2wv9A:
18.40