SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wvf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR
(Helicobacter
pylori) 		4 / 6 GLY A 129
TYR A  72
ALA A 136
GLU A 109
 None
None
None
FMT  A1147 ( 4.5A)
 0.84A 1dmaB-2wvfA:
undetectable		 1dmaB-2wvfA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR
(Helicobacter
pylori) 		4 / 4 LYS A 140
LEU A 138
ALA A  66
LEU A  68
 None
 0.64A 1f86B-2wvfA:
undetectable		 1f86B-2wvfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR
(Helicobacter
pylori) 		4 / 7 LYS A 140
LEU A 138
ALA A  66
LEU A  68
 None
 0.65A 4d7bA-2wvfA:
undetectable		 4d7bA-2wvfA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR
(Helicobacter
pylori) 		4 / 8 LYS A 140
LEU A 138
ALA A  66
LEU A  68
 None
 0.64A 4iizB-2wvfA:
undetectable		 4iizB-2wvfA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR
(Helicobacter
pylori) 		4 / 4 VAL A  15
LEU A  17
LEU A  22
ASP A  26
 None
 1.37A 5xv7A-2wvfA:
2.2		 5xv7A-2wvfA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR
(Helicobacter
pylori) 		3 / 3 LEU A 138
GLN A 124
LYS A  64
 None
 0.91A 6exiB-2wvfA:
undetectable		 6exiB-2wvfA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR
(Helicobacter
pylori) 		3 / 3 LEU A 138
GLN A 124
LYS A  64
 None
 0.92A 6exiA-2wvfA:
undetectable		 6exiA-2wvfA:
18.71