SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 12 VAL A 199
LEU A 203
LYS A 338
ALA A 307
ILE A 281
 None
 0.98A 1epbA-2wvgA:
undetectable		 1epbA-2wvgA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 7 VAL A 151
LEU A 164
SER A  98
ALA A  77
 None
 0.89A 1j8uA-2wvgA:
undetectable		 1j8uA-2wvgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 6 GLU A 126
THR A 132
TYR A 163
TYR A 139
 None
 1.33A 1qvuA-2wvgA:
undetectable		 1qvuA-2wvgA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 11 ILE A 385
GLU A  58
GLY A 416
THR A 446
GLU A 387
 None
 1.37A 2fn1A-2wvgA:
undetectable		 2fn1A-2wvgA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 5 LEU A 378
ARG A 433
ALA A 404
ILE A 435
 None
 1.03A 2qhfA-2wvgA:
undetectable		 2qhfA-2wvgA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 6 LEU A  13
LEU A   9
ILE A  16
ARG A  12
 None
 1.00A 2rlfC-2wvgA:
undetectable
2rlfD-2wvgA:
undetectable		 2rlfC-2wvgA:
5.87
2rlfD-2wvgA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 6 LEU A  32
ILE A  97
ILE A 131
LEU A  78
 None
 0.98A 2xkwB-2wvgA:
undetectable		 2xkwB-2wvgA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		3 / 3 MET A 410
VAL A 406
GLU A 387
 None
 0.83A 3c6gA-2wvgA:
undetectable		 3c6gA-2wvgA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 12 ALA A 100
ILE A 170
ILE A 148
PRO A 145
ILE A  97
 None
 1.23A 3clbB-2wvgA:
undetectable		 3clbB-2wvgA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 12 ALA A  63
GLY A  59
GLY A  65
ALA A 426
HIS A  20
 None
 1.15A 3ou6B-2wvgA:
undetectable		 3ou6B-2wvgA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 12 ALA A  63
GLY A  59
GLY A  65
ALA A 426
HIS A  20
 None
 1.17A 3ou7B-2wvgA:
undetectable		 3ou7B-2wvgA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 12 GLY A  54
PRO A 420
ASN A  49
ALA A 421
PHE A  81
 None
 0.99A 3p2kC-2wvgA:
3.1		 3p2kC-2wvgA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 11 GLY A 416
GLU A 387
HIS A 414
THR A 388
GLU A 409
 None
None
TPU  A 600 (-3.3A)
TPU  A 600 ( 4.7A)
None
 1.49A 3r76A-2wvgA:
2.1		 3r76A-2wvgA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 11 GLY A 416
GLU A 387
HIS A 414
THR A 388
GLU A 409
 None
None
TPU  A 600 (-3.3A)
TPU  A 600 ( 4.7A)
None
 1.50A 3r76B-2wvgA:
2.1		 3r76B-2wvgA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 12 ASN A  29
GLN A 124
ALA A  77
SER A  74
TYR A 123
 None
 1.46A 4ejwA-2wvgA:
0.0		 4ejwA-2wvgA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		3 / 3 LEU A  92
PRO A  93
ARG A 405
 None
 0.60A 4klrB-2wvgA:
2.5		 4klrB-2wvgA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 6 SER A 172
GLY A  26
ASP A  27
GLY A  99
 None
F  A 569 ( 3.1A)
F  A 569 (-3.8A)
None
 1.04A 4koeA-2wvgA:
undetectable
4koeB-2wvgA:
undetectable
4koeC-2wvgA:
undetectable		 4koeA-2wvgA:
22.48
4koeB-2wvgA:
22.48
4koeC-2wvgA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 7 CYH A 537
LEU A 518
GLY A 516
GLY A 515
 None
 0.86A 5a06A-2wvgA:
2.2		 5a06A-2wvgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 7 CYH A 537
LEU A 518
GLY A 516
GLY A 515
 None
 0.83A 5a06B-2wvgA:
2.5		 5a06B-2wvgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 7 CYH A 537
LEU A 518
GLY A 516
GLY A 515
 None
 0.83A 5a06C-2wvgA:
3.3		 5a06C-2wvgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 6 CYH A 537
GLU A 517
GLY A 516
GLY A 515
 None
 1.02A 5a06D-2wvgA:
2.7		 5a06D-2wvgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 7 CYH A 537
LEU A 518
GLY A 516
GLY A 515
 None
 0.85A 5a06E-2wvgA:
2.5		 5a06E-2wvgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 7 CYH A 537
LEU A 518
GLY A 516
GLY A 515
 None
 0.86A 5a06F-2wvgA:
undetectable		 5a06F-2wvgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 12 ASP A  82
PRO A 420
GLY A  59
GLU A  58
GLU A 409
 None
 1.26A 5hfjA-2wvgA:
undetectable		 5hfjA-2wvgA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 5 SER A  98
VAL A  71
GLY A  76
ALA A  77
 None
 0.91A 5k50A-2wvgA:
undetectable		 5k50A-2wvgA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 9 ALA A  69
ILE A  16
LEU A  13
ILE A 152
ALA A  57
 None
 0.94A 5nunA-2wvgA:
undetectable		 5nunA-2wvgA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		5 / 12 ALA A 282
GLU A 226
LEU A 324
VAL A 240
PHE A 250
 None
 1.47A 5vlmC-2wvgA:
undetectable		 5vlmC-2wvgA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 7 ALA A  10
THR A   7
TYR A   8
VAL A  14
 None
 0.88A 6cduA-2wvgA:
undetectable
6cduE-2wvgA:
undetectable		 6cduA-2wvgA:
18.36
6cduE-2wvgA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 8 VAL A  14
ALA A  10
THR A   7
TYR A   8
 None
 0.87A 6cduD-2wvgA:
undetectable
6cduE-2wvgA:
undetectable		 6cduD-2wvgA:
18.36
6cduE-2wvgA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2wvg PYRUVATE
DECARBOXYLASE
(Zymomonas
mobilis) 		4 / 7 VAL A  14
ALA A  10
THR A   7
TYR A   8
 None
 0.86A 6cduH-2wvgA:
undetectable
6cduI-2wvgA:
undetectable		 6cduH-2wvgA:
18.36
6cduI-2wvgA:
18.36