SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		4 / 6 HIS A 318
ILE A 319
ALA A 351
VAL A 221
 GDD  A 400 ( 4.9A)
None
None
None
 1.02A 1hk1A-2wvlA:
2.6		 1hk1A-2wvlA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		4 / 6 LEU A 157
PHE A 154
ALA A 155
LEU A 374
 None
 0.92A 1ukbA-2wvlA:
undetectable		 1ukbA-2wvlA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 155
LEU A 369
LEU A 152
ILE A 149
LEU A 125
 None
 1.25A 1xdkB-2wvlA:
undetectable		 1xdkB-2wvlA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ILE A 149
LEU A 150
GLY A 143
SER A 142
GLU A 146
 None
None
GDD  A 400 (-3.1A)
GDD  A 400 ( 4.9A)
None
 1.22A 2a58A-2wvlA:
2.2
2a58B-2wvlA:
2.2		 2a58A-2wvlA:
18.60
2a58B-2wvlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ILE A 149
LEU A 150
GLY A 143
SER A 142
GLU A 146
 None
None
GDD  A 400 (-3.1A)
GDD  A 400 ( 4.9A)
None
 1.22A 2a58B-2wvlA:
2.2
2a58C-2wvlA:
2.5		 2a58B-2wvlA:
18.60
2a58C-2wvlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ILE A 149
LEU A 150
GLY A 143
SER A 142
GLU A 146
 None
None
GDD  A 400 (-3.1A)
GDD  A 400 ( 4.9A)
None
 1.22A 2a58D-2wvlA:
undetectable
2a58E-2wvlA:
2.2		 2a58D-2wvlA:
18.60
2a58E-2wvlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ASN A 170
GLU A 251
GLY A 164
MET A   1
VAL A 176
 None
ZN  A1393 (-2.4A)
None
None
None
 0.89A 3nk7A-2wvlA:
undetectable		 3nk7A-2wvlA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 ALA A 253
GLY A 186
ASP A  45
ARG A  49
VAL A  51
 None
 1.12A 3o7wA-2wvlA:
undetectable		 3o7wA-2wvlA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 10 VAL A 244
VAL A  15
ILE A 300
GLN A 302
ILE A 233
 None
 1.28A 3retA-2wvlA:
undetectable
3retB-2wvlA:
undetectable		 3retA-2wvlA:
15.41
3retB-2wvlA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 HIS A 115
GLU A  96
ASN A  63
 None
 0.91A 4bupB-2wvlA:
undetectable		 4bupB-2wvlA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 10 ASP A 290
VAL A 298
TYR A 282
GLY A  13
THR A 192
 None
 1.50A 4mm7A-2wvlA:
undetectable		 4mm7A-2wvlA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 LEU A 229
GLN A 231
LEU A 327
ARG A 224
GLN A 273
 None
 1.39A 4p6xI-2wvlA:
undetectable		 4p6xI-2wvlA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		4 / 4 LEU A  83
ARG A 109
ILE A  82
ILE A  76
 None
 1.32A 5dzk2-2wvlA:
undetectable
5dzkM-2wvlA:
undetectable
5dzkN-2wvlA:
undetectable		 5dzk2-2wvlA:
2.90
5dzkM-2wvlA:
19.85
5dzkN-2wvlA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		4 / 6 VAL A 340
ALA A 336
VAL A 330
TYR A 331
 None
 1.07A 5i8fA-2wvlA:
undetectable		 5i8fA-2wvlA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 VAL A 176
GLU A 251
LEU A  99
LEU A  73
ARG A  65
 None
ZN  A1393 (-2.4A)
None
None
None
 1.19A 5nd3B-2wvlA:
undetectable		 5nd3B-2wvlA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		5 / 12 GLY A  75
SER A  74
GLU A  64
LEU A  69
GLU A  70
 None
None
GDD  A 400 (-3.7A)
None
None
 1.21A 5nwvA-2wvlA:
undetectable		 5nwvA-2wvlA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 HIS A 115
SER A  86
ARG A  62
 None
 0.97A 5u63A-2wvlA:
1.4		 5u63A-2wvlA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 HIS A 115
GLU A  96
ASN A  63
 None
 1.00A 5wbvA-2wvlA:
undetectable		 5wbvA-2wvlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 HIS A 115
GLU A  96
ASN A  63
 None
 1.00A 5wbvB-2wvlA:
undetectable		 5wbvB-2wvlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 LEU A  17
LEU A 275
ARG A 198
 None
 0.55A 6fgcA-2wvlA:
2.3		 6fgcA-2wvlA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE
(Thermus
thermophilus) 		3 / 3 LEU A  17
LEU A 275
ARG A 198
 None
 0.60A 6fgdA-2wvlA:
undetectable		 6fgdA-2wvlA:
23.43