SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2wvq SMALL S PROTEIN
(Podospora
anserina) 		3 / 3 ILE A 207
ASP A  46
PHE A  25
 None
 0.58A 1uwjB-2wvqA:
undetectable		 1uwjB-2wvqA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2wvq SMALL S PROTEIN
(Podospora
anserina) 		4 / 6 PHE A  91
VAL A 160
LEU A 156
ALA A  94
 None
 0.93A 2e1qC-2wvqA:
undetectable		 2e1qC-2wvqA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 2wvq SMALL S PROTEIN
(Podospora
anserina) 		4 / 4 LYS A 218
LEU A 197
ALA A 214
LEU A 200
 None
 1.40A 2roxA-2wvqA:
undetectable		 2roxA-2wvqA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 2wvq SMALL S PROTEIN
(Podospora
anserina) 		5 / 10 LEU A  43
ALA A  50
ILE A 188
ALA A 203
ILE A  47
 None
 0.98A 3ekpC-2wvqA:
undetectable		 3ekpC-2wvqA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2wvq SMALL S PROTEIN
(Podospora
anserina) 		5 / 12 ALA A 214
ALA A 215
LEU A 200
ARG A  54
ALA A 184
 None
 1.23A 3uvvB-2wvqA:
undetectable		 3uvvB-2wvqA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2wvq SMALL S PROTEIN
(Podospora
anserina) 		3 / 3 ARG A 165
ARG A  44
ASP A 208
 None
 1.01A 3wipG-2wvqA:
undetectable
3wipH-2wvqA:
undetectable		 3wipG-2wvqA:
25.00
3wipH-2wvqA:
25.00