SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ww8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 LEU A 101
GLU A 103
THR A  82
LEU A  69
 None
 1.17A 1etb2-2ww8A:
6.9		 1etb2-2ww8A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 LEU A 801
GLU A 803
THR A 783
LEU A 758
 None
 1.14A 1etb2-2ww8A:
6.9		 1etb2-2ww8A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 LEU A 363
ILE A 369
PHE A 358
THR A 278
ILE A 279
 None
 1.31A 1i18A-2ww8A:
undetectable
1i18B-2ww8A:
undetectable		 1i18A-2ww8A:
8.18
1i18B-2ww8A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 THR A 783
ILE A 818
GLU A 855
TYR A 810
ASN A 746
 None
 1.18A 1jtxA-2ww8A:
undetectable		 1jtxA-2ww8A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 ASP A 533
LEU A 370
GLY A 531
ASP A 530
 None
None
None
CA  A1001 (-2.9A)
 0.92A 1rmtC-2ww8A:
3.1		 1rmtC-2ww8A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A 259
THR A 255
ARG A 256
ILE A 369
LEU A 324
 None
 1.11A 1tw4B-2ww8A:
undetectable		 1tw4B-2ww8A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 9 THR A 386
ALA A 362
LEU A 363
GLU A 368
LEU A 322
 None
 1.04A 2azqA-2ww8A:
4.3		 2azqA-2ww8A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 8 VAL A 227
VAL A 270
LEU A 258
THR A 255
 None
 0.92A 2gehA-2ww8A:
undetectable		 2gehA-2ww8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 LEU A 647
ILE A 598
VAL A 652
ALA A 650
LEU A 668
 None
 1.24A 2japB-2ww8A:
3.4		 2japB-2ww8A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 PRO A 390
GLY A 516
TYR A 448
 None
 0.44A 2vouA-2ww8A:
undetectable		 2vouA-2ww8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 PRO A 390
GLY A 516
TYR A 448
 None
 0.51A 2vouB-2ww8A:
3.6		 2vouB-2ww8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 PRO A 390
GLY A 516
TYR A 448
 None
 0.53A 2vouC-2ww8A:
undetectable		 2vouC-2ww8A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 ARG A 349
GLY A 347
SER A 277
 None
 0.47A 2xctB-2ww8A:
undetectable		 2xctB-2ww8A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 PRO A 224
LEU A 225
GLN A 218
 None
 0.53A 3hznG-2ww8A:
undetectable
3hznH-2ww8A:
undetectable		 3hznG-2ww8A:
12.88
3hznH-2ww8A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 4 GLY A 212
VAL A 210
GLY A 665
THR A 664
 None
 0.90A 3ib2A-2ww8A:
undetectable		 3ib2A-2ww8A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 HIS A 400
ALA A 401
GLN A 410
TYR A 407
 None
None
None
EPE  A1100 (-4.1A)
 1.47A 4gboB-2ww8A:
undetectable		 4gboB-2ww8A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 SER A 320
ALA A 271
VAL A 270
 None
 0.67A 4o2bC-2ww8A:
undetectable		 4o2bC-2ww8A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLU A 181
GLY A 187
GLU A 186
LEU A 623
ALA A 625
 EPE  A1101 (-3.2A)
None
None
None
None
 1.27A 4wcxC-2ww8A:
undetectable		 4wcxC-2ww8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 GLN A 578
PHE A 535
PHE A 383
LEU A 258
 None
 1.15A 5b1bC-2ww8A:
undetectable
5b1bJ-2ww8A:
undetectable		 5b1bC-2ww8A:
13.83
5b1bJ-2ww8A:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 THR A 359
ALA A 362
TYR A 522
HIS A 384
 None
 1.21A 5ecmA-2ww8A:
1.2		 5ecmA-2ww8A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 PHE A 358
VAL A 441
TYR A 503
ILE A 396
ILE A 512
 None
 1.26A 5hw8B-2ww8A:
undetectable		 5hw8B-2ww8A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 11 PHE A 358
VAL A 441
TYR A 503
ILE A 396
ILE A 512
 None
 1.24A 5hw8G-2ww8A:
undetectable		 5hw8G-2ww8A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 TYR A 352
ALA A 356
GLN A 446
THR A 391
 None
 1.31A 5n0wB-2ww8A:
undetectable		 5n0wB-2ww8A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 TYR A 352
ALA A 356
GLN A 446
THR A 391
 None
 1.37A 5n4iA-2ww8A:
2.1		 5n4iA-2ww8A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 LYS A 731
LYS A 115
SER A 113
 None
 1.23A 5odiA-2ww8A:
4.6		 5odiA-2ww8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ASN A 626
SER A 629
LEU A 646
PRO A 640
 None
 1.03A 5u4sA-2ww8A:
2.3		 5u4sA-2ww8A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 ILE A 541
ILE A 539
ALA A 251
THR A 255
ILE A 229
 None
 1.10A 5vceA-2ww8A:
undetectable		 5vceA-2ww8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 ILE A 193
ILE A 206
LEU A 208
ILE A 160
ASN A 178
 None
None
None
None
EPE  A1101 ( 4.8A)
 1.16A 5vkqA-2ww8A:
undetectable
5vkqD-2ww8A:
undetectable		 5vkqA-2ww8A:
18.93
5vkqD-2ww8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 ILE A 160
ASN A 178
ILE A 193
ILE A 206
LEU A 208
 None
EPE  A1101 ( 4.8A)
None
None
None
 1.17A 5vkqA-2ww8A:
undetectable
5vkqB-2ww8A:
undetectable		 5vkqA-2ww8A:
18.93
5vkqB-2ww8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		5 / 10 ILE A 160
ASN A 178
ILE A 193
ILE A 206
LEU A 208
 None
EPE  A1101 ( 4.8A)
None
None
None
 1.14A 5vkqC-2ww8A:
undetectable
5vkqD-2ww8A:
undetectable		 5vkqC-2ww8A:
18.93
5vkqD-2ww8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		3 / 3 GLY A 546
ASP A 544
ILE A 541
 None
 0.52A 6dgxB-2ww8A:
undetectable		 6dgxB-2ww8A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN
(Streptococcus
pneumoniae) 		4 / 6 VAL A 569
ASN A 568
ASN A 542
ILE A 541
 None
 1.02A 6h7uA-2ww8A:
undetectable		 6h7uA-2ww8A:
17.83