SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ww9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 1.00A 1c6zA-2ww9A:
undetectable		 1c6zA-2ww9A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 1.01A 1c6zB-2ww9A:
undetectable		 1c6zB-2ww9A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  67
SER A 355
SER A 348
ALA A 351
 None
 1.10A 1fxvA-2ww9A:
undetectable
1fxvB-2ww9A:
1.0		 1fxvA-2ww9A:
17.50
1fxvB-2ww9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 THR A 164
GLY A 159
LEU A 157
TYR A 128
 None
 0.79A 1gtiA-2ww9A:
undetectable		 1gtiA-2ww9A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_B_CCSB47_0
(GLUTATHIONE
S-TRANSFERASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 THR A 164
GLY A 159
LEU A 157
TYR A 128
 None
 0.87A 1gtiB-2ww9A:
undetectable		 1gtiB-2ww9A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 THR A 164
GLY A 159
LEU A 157
TYR A 128
 None
 1.04A 1gtiD-2ww9A:
undetectable		 1gtiD-2ww9A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 THR A 164
GLY A 159
LEU A 157
TYR A 128
 None
 0.94A 1gtiE-2ww9A:
undetectable		 1gtiE-2ww9A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
PROTEIN TRANSPORT
PROTEIN SSS1
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 GLY B  32
GLN B  34
VAL A 268
ALA A 426
 None
 1.03A 1p6kA-2ww9B:
undetectable		 1p6kA-2ww9B:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 471
ILE A 467
SER A 178
PHE A 177
ILE A  33
 None
 1.37A 1xotA-2ww9A:
undetectable		 1xotA-2ww9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 353
VAL A 296
SER A 435
VAL A 454
LEU A 434
 None
 1.32A 1z9hA-2ww9A:
undetectable		 1z9hA-2ww9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 353
VAL A 296
SER A 435
VAL A 454
LEU A 434
 None
 1.32A 1z9hB-2ww9A:
1.8		 1z9hB-2ww9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 353
VAL A 296
SER A 435
VAL A 454
LEU A 434
 None
 1.32A 1z9hC-2ww9A:
undetectable		 1z9hC-2ww9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 176
PRO A  28
ASP A  31
TYR A  35
 None
 0.98A 2aouB-2ww9A:
undetectable		 2aouB-2ww9A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.97A 2f80A-2ww9A:
undetectable		 2f80A-2ww9A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.93A 2f80B-2ww9A:
undetectable		 2f80B-2ww9A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.96A 2f81A-2ww9A:
undetectable		 2f81A-2ww9A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 180
ALA A 181
ILE A  88
GLY A  73
PRO A  86
 None
 0.79A 2hs1A-2ww9A:
undetectable		 2hs1A-2ww9A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.96A 2pymA-2ww9A:
undetectable		 2pymA-2ww9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.97A 2pymB-2ww9A:
undetectable		 2pymB-2ww9A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.95A 3cywA-2ww9A:
undetectable		 3cywA-2ww9A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_2
(HIV-1 PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.96A 3cywB-2ww9A:
undetectable		 3cywB-2ww9A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.94A 3d1zA-2ww9A:
undetectable		 3d1zA-2ww9A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_1
(HIV-1 PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.94A 3d20A-2ww9A:
undetectable		 3d20A-2ww9A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_2
(PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 11 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.95A 3ektD-2ww9A:
undetectable		 3ektD-2ww9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 11 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.93A 3ekxA-2ww9A:
undetectable		 3ekxA-2ww9A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.95A 3jvyA-2ww9A:
undetectable		 3jvyA-2ww9A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 312
ILE A 153
ALA A 138
LEU A 316
 None
 0.87A 3kk6B-2ww9A:
undetectable		 3kk6B-2ww9A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_1
(HIV-1 PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.93A 3lzsA-2ww9A:
undetectable		 3lzsA-2ww9A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZS_A_017A200_2
(HIV-1 PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.94A 3lzsB-2ww9A:
undetectable		 3lzsB-2ww9A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_1
(HIV-1 PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.96A 3lzuA-2ww9A:
undetectable		 3lzuA-2ww9A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.99A 3pwmA-2ww9A:
undetectable		 3pwmA-2ww9A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 11 THR A 164
THR A 191
VAL A 187
LEU A  84
VAL A  71
 None
 1.27A 3tbgA-2ww9A:
undetectable		 3tbgA-2ww9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC2_1
(CYTOCHROME P450 2D6)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 10 THR A 164
THR A 191
VAL A 187
LEU A  84
VAL A  71
 None
 1.29A 3tbgC-2ww9A:
1.4		 3tbgC-2ww9A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 1.00A 3tkgD-2ww9A:
undetectable		 3tkgD-2ww9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  83
GLY A  73
GLU A  75
ALA A 160
LEU A 157
 None
 1.16A 3vywA-2ww9A:
undetectable		 3vywA-2ww9A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  38
VAL A 187
ILE A 183
 None
 0.62A 4emaA-2ww9A:
undetectable		 4emaA-2ww9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.94A 4jecB-2ww9A:
undetectable		 4jecB-2ww9A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.93A 4njvA-2ww9A:
undetectable		 4njvA-2ww9A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  40
ALA A  39
VAL A 170
ILE A  33
ILE A 171
 None
 0.92A 4njvD-2ww9A:
undetectable		 4njvD-2ww9A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2ww9 PROTEIN TRANSPORT
PROTEIN SSS1
SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  46
ASN A 185
GLY A  73
ALA A 195
ILE B  68
 None
 0.90A 4nkxB-2ww9A:
undetectable		 4nkxB-2ww9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 464
GLY A 460
GLN A 264
MET A 182
ILE A 183
 None
 1.13A 4ok1A-2ww9A:
undetectable		 4ok1A-2ww9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 2ww9 PROTEIN TRANSPORT
PROTEIN SSS1
SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 464
GLY A 460
VAL B  54
MET A 182
ILE A 183
 None
 1.35A 4oktA-2ww9A:
undetectable		 4oktA-2ww9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 464
GLY A 460
GLN A 264
MET A 182
ILE A 183
 None
 1.12A 4oktA-2ww9A:
undetectable		 4oktA-2ww9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 2ww9 PROTEIN TRANSPORT
PROTEIN SSS1
SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 464
GLY A 460
GLN A 264
VAL B  54
MET A 182
 None
 1.30A 4olmA-2ww9A:
undetectable		 4olmA-2ww9A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
PROTEIN TRANSPORT
PROTEIN SEB2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLY A 159
GLN A 156
ILE C  76
GLY C  70
PHE C  71
 None
 1.11A 4r29D-2ww9A:
undetectable		 4r29D-2ww9A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 441
LEU A 436
LEU A 446
GLY A 452
ILE A 453
 None
 0.99A 5d4uC-2ww9A:
undetectable		 5d4uC-2ww9A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 180
ALA A 181
ILE A  88
GLY A  73
PRO A  86
 None
 0.80A 5e5kA-2ww9A:
undetectable		 5e5kA-2ww9A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2ww9 PROTEIN TRANSPORT
PROTEIN SSS1
SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 258
LEU A 254
VAL B  54
ALA B  53
SER A 265
 None
 0.93A 5km9B-2ww9A:
undetectable		 5km9B-2ww9A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 297
ALA A 168
VAL A 455
MET A 182
 None
 0.93A 5nu7A-2ww9A:
undetectable		 5nu7A-2ww9A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  52
LEU A  79
LEU A  80
GLU A  81
LEU A 157
 None
 1.26A 5nwwA-2ww9A:
undetectable		 5nwwA-2ww9A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 314
ILE A 130
LEU A 131
PHE A 123
 None
 0.95A 5vkqA-2ww9A:
undetectable
5vkqB-2ww9A:
undetectable		 5vkqA-2ww9A:
14.69
5vkqB-2ww9A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 314
ILE A 130
LEU A 131
PHE A 123
 None
 0.94A 5vkqB-2ww9A:
undetectable
5vkqC-2ww9A:
undetectable		 5vkqB-2ww9A:
14.69
5vkqC-2ww9A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 314
ILE A 130
LEU A 131
PHE A 123
 None
 0.91A 5vkqC-2ww9A:
undetectable
5vkqD-2ww9A:
undetectable		 5vkqC-2ww9A:
14.69
5vkqD-2ww9A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 123
ILE A 314
ILE A 130
LEU A 131
 None
 0.92A 5vkqA-2ww9A:
undetectable
5vkqD-2ww9A:
undetectable		 5vkqA-2ww9A:
14.69
5vkqD-2ww9A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  25
ASP A  31
PRO A  28
 None
 0.79A 6berA-2ww9A:
undetectable		 6berA-2ww9A:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 372
THR A 369
TYR A 370
VAL A 376
 None
 0.97A 6cduA-2ww9A:
1.8
6cduE-2ww9A:
1.7		 6cduA-2ww9A:
20.85
6cduE-2ww9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 376
ALA A 372
THR A 369
TYR A 370
 None
 0.95A 6cduH-2ww9A:
1.9
6cduI-2ww9A:
1.8		 6cduH-2ww9A:
20.85
6cduI-2ww9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 296
LEU A 263
GLY A 459
LEU A 289
VAL A 454
 None
 1.26A 6czmA-2ww9A:
undetectable
6czmB-2ww9A:
undetectable		 6czmA-2ww9A:
20.80
6czmB-2ww9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 296
LEU A 263
GLY A 459
LEU A 289
VAL A 454
 None
 1.29A 6czmB-2ww9A:
undetectable
6czmC-2ww9A:
undetectable		 6czmB-2ww9A:
20.80
6czmC-2ww9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 296
LEU A 263
GLY A 459
LEU A 289
VAL A 454
 None
 1.25A 6czmD-2ww9A:
undetectable
6czmE-2ww9A:
undetectable		 6czmD-2ww9A:
20.80
6czmE-2ww9A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 149
VAL A  51
GLU A  81
ALA A 138
 None
 1.13A 6djzB-2ww9A:
undetectable		 6djzB-2ww9A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
PROTEIN TRANSPORT
PROTEIN SEB2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 9 SER C  68
GLY C  70
ILE C  72
PHE C  73
PHE A  38
 None
 1.33A 6ebpA-2ww9C:
undetectable		 6ebpA-2ww9C:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 141
VAL A 312
PRO A  76
VAL A  61
 None
 1.40A 6ekzA-2ww9A:
undetectable		 6ekzA-2ww9A:
12.53