SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wwd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		4 / 6 PRO A 377
ASP A 337
ASN A 340
ASP A 341
 None
 1.35A 1hpkA-2wwdA:
undetectable		 1hpkA-2wwdA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A 376
LEU A 415
ILE A 387
ILE A 386
LEU A 410
 None
 0.95A 1xdkF-2wwdA:
undetectable		 1xdkF-2wwdA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		4 / 4 TRP A  59
TRP A  68
TYR A  86
MET A  94
 CHT  A 702 (-3.6A)
CHT  A 702 (-3.9A)
CHT  A 702 (-3.7A)
CHT  A 702 ( 3.5A)
 0.64A 2x8oA-2wwdA:
10.6		 2x8oA-2wwdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		4 / 4 TRP A  99
TRP A 108
TYR A 130
MET A 138
 CHT  A 704 (-3.7A)
CHT  A 704 (-3.6A)
CHT  A 704 (-4.6A)
CHT  A 704 (-3.4A)
 0.31A 2x8oA-2wwdA:
10.6		 2x8oA-2wwdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		4 / 4 TRP A 122
TRP A 129
TYR A 147
MET A 155
 CHT  A 705 ( 3.7A)
CHT  A 705 (-4.1A)
CHT  A 705 ( 4.0A)
CHT  A 705 ( 4.1A)
 0.80A 2x8oA-2wwdA:
10.6		 2x8oA-2wwdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1317_1
(CHOLINE-BINDING
PROTEIN F)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		4 / 4 TRP A 183
TRP A 190
TYR A 208
MET A 216
 None
 0.71A 2x8oA-2wwdA:
10.6		 2x8oA-2wwdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8P_A_OINA1313_1
(CHOLINE-BINDING
PROTEIN F)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		4 / 4 TRP A 183
LYS A 185
TRP A 190
TYR A 208
 None
 0.80A 2x8pA-2wwdA:
4.6		 2x8pA-2wwdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		5 / 10 PRO A 323
ILE A 288
TYR A 358
ILE A 271
ILE A 272
 None
 1.06A 3p4wD-2wwdA:
undetectable		 3p4wD-2wwdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		5 / 10 PRO A 323
ILE A 288
TYR A 358
ILE A 271
ILE A 272
 None
 1.05A 3p4wE-2wwdA:
undetectable		 3p4wE-2wwdA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		4 / 4 LEU A 300
ILE A 271
TYR A 405
TYR A 324
 None
None
NAG  A 469 (-4.8A)
None
 1.33A 3vt7A-2wwdA:
undetectable		 3vt7A-2wwdA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		5 / 11 GLY A 398
ALA A 397
ILE A 346
LEU A 356
ILE A 360
 None
 1.05A 4dt8A-2wwdA:
undetectable		 4dt8A-2wwdA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		5 / 10 GLY A 398
ALA A 397
ILE A 346
LEU A 356
ILE A 360
 None
 1.04A 4dt8B-2wwdA:
undetectable		 4dt8B-2wwdA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		3 / 3 GLU A 292
ARG A 253
HIS A 248
 None
GOL  A 607 (-3.4A)
None
 0.85A 4kf9A-2wwdA:
undetectable		 4kf9A-2wwdA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		5 / 11 ASN A 438
HIS A 423
VAL A 424
VAL A 404
LEU A 415
 None
 1.39A 4ygfA-2wwdA:
undetectable		 4ygfA-2wwdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		5 / 11 ASN A 438
HIS A 423
VAL A 424
VAL A 404
LEU A 415
 None
 1.34A 4ygfB-2wwdA:
undetectable		 4ygfB-2wwdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		5 / 12 ASN A 438
HIS A 423
VAL A 424
VAL A 404
LEU A 415
 None
 1.40A 4ygfE-2wwdA:
undetectable		 4ygfE-2wwdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_F_AZMF303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		5 / 9 ASN A 438
HIS A 423
VAL A 424
VAL A 404
LEU A 415
 None
 1.34A 4ygfF-2wwdA:
undetectable		 4ygfF-2wwdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		3 / 3 ARG A 299
LYS A 308
GLU A 276
 None
 0.78A 5d0yA-2wwdA:
undetectable		 5d0yA-2wwdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		3 / 3 VAL A 402
TYR A 399
GLN A 400
 None
 0.71A 5qgkA-2wwdA:
undetectable		 5qgkA-2wwdA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 2wwd 1,4-BETA-N-ACETYLMUR
AMIDASE
(Streptococcus
pneumoniae) 		3 / 3 VAL A 402
TYR A 399
GLN A 400
 None
 0.75A 5qgtA-2wwdA:
undetectable		 5qgtA-2wwdA:
16.74