SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB153_0 (ILEAL BILE ACID-BINDING PROTEIN)	2wwe	PHOSPHOINOSITIDE-3-K INASE, CLASS 2, GAMMA POLYPEPTIDE (Homo sapiens)	4 / 7	ILE A1222 PHE A1260 PHE A1238 GLY A1211	None	1.05A	3em0B-2wweA: undetectable	3em0B-2wweA: 17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CD2_A_FOLA207_0 (DIHYDROFOLATE REDUCTASE)	2wwe	PHOSPHOINOSITIDE-3-K INASE, CLASS 2, GAMMA POLYPEPTIDE (Homo sapiens)	5 / 12	ILE A1204 ILE A1222 PHE A1303 LEU A1244 THR A1225	None	1.26A	4cd2A-2wweA: undetectable	4cd2A-2wweA: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PL1_A_SAMA401_0 (DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN)	2wwe	PHOSPHOINOSITIDE-3-K INASE, CLASS 2, GAMMA POLYPEPTIDE (Homo sapiens)	5 / 11	GLU A1306 SER A1232 HIS A1226 ILE A1204 ASN A1295	None	1.49A	4pl1A-2wweA: 0.0	4pl1A-2wweA: 14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6B58_A_ACTA609_0 (FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT)	2wwe	PHOSPHOINOSITIDE-3-K INASE, CLASS 2, GAMMA POLYPEPTIDE (Homo sapiens)	3 / 3	HIS A1262 HIS A1265 ARG A1274	None	1.05A	6b58A-2wweA: undetectable	6b58A-2wweA: 11.40

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3EM0_B_CHDB153_0","ILEAL BILE ACID-BINDING PROTEIN","2wwe","PHOSPHOINOSITIDE-3-KINASE, CLASS 2, GAMMA POLYPEPTIDE","Homo sapiens",4,"ILE A1222;PHE A1260;PHE A1238;GLY A1211","None","1.05A","3em0B-2wweA:undetectable","3em0B-2wweA:17.22"],["4CD2_A_FOLA207_0","DIHYDROFOLATE REDUCTASE","2wwe","PHOSPHOINOSITIDE-3-KINASE, CLASS 2, GAMMA POLYPEPTIDE","Homo sapiens",5,"ILE A1204;ILE A1222;PHE A1303;LEU A1244;THR A1225","None","1.26A","4cd2A-2wweA:undetectable","4cd2A-2wweA:19.23"],["4PL1_A_SAMA401_0","DUAL-SPECIFICITY RNA METHYLTRANSFERASE RLMN","2wwe","PHOSPHOINOSITIDE-3-KINASE, CLASS 2, GAMMA POLYPEPTIDE","Homo sapiens",5,"GLU A1306;SER A1232;HIS A1226;ILE A1204;ASN A1295","None","1.49A","4pl1A-2wweA:0.0","4pl1A-2wweA:14.89"],["6B58_A_ACTA609_0","FUMARATE REDUCTASE FLAVOPROTEIN SUBUNIT","2wwe","PHOSPHOINOSITIDE-3-KINASE, CLASS 2, GAMMA POLYPEPTIDE","Homo sapiens",3,"HIS A1262;HIS A1265;ARG A1274","None","1.05A","6b58A-2wweA:undetectable","6b58A-2wweA:11.40"]]