SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2www'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 240
VAL A 176
GLY A 147
LEU A 148
SER A 149
 None
 0.93A 2v3kA-2wwwA:
undetectable		 2v3kA-2wwwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 127
LEU A 128
ILE A  94
GLY A 233
LEU A 230
 None
 1.19A 2yjaB-2wwwA:
undetectable		 2yjaB-2wwwA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO A 151
GLY A 153
ALA A 154
ALA A 267
 None
GDP  A 600 (-3.5A)
GDP  A 600 (-4.2A)
None
 0.77A 3ur0B-2wwwA:
undetectable		 3ur0B-2wwwA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLY A 150
GLU A 242
THR A 243
 None
 0.57A 4kouA-2wwwA:
undetectable		 4kouA-2wwwA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 263
GLU A 250
VAL A 179
ALA A 178
 None
 1.11A 4nkvC-2wwwA:
undetectable		 4nkvC-2wwwA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU A 127
LEU A 128
ILE A  94
GLY A 233
LEU A 230
 None
 1.20A 5dxbB-2wwwA:
undetectable		 5dxbB-2wwwA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A 229
ILE A 228
GLY A 233
ILE A 239
 None
 0.89A 5dzk3-2wwwA:
undetectable
5dzkm-2wwwA:
undetectable		 5dzk3-2wwwA:
3.70
5dzkm-2wwwA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ILE A 228
GLY A 233
ILE A 239
LEU A 229
 None
 0.88A 5dzki-2wwwA:
undetectable
5dzkj-2wwwA:
undetectable
5dzkx-2wwwA:
undetectable		 5dzki-2wwwA:
22.19
5dzkj-2wwwA:
22.19
5dzkx-2wwwA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 148
ILE A 238
PHE A 159
LEU A 285
 None
 0.86A 5eseA-2wwwA:
undetectable		 5eseA-2wwwA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 TRP A 366
ILE A 228
HIS A 130
LEU A 230
VAL A 126
 None
 1.15A 5im2A-2wwwA:
undetectable		 5im2A-2wwwA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 VAL A 108
GLU A 377
GLU A 373
 None
 0.85A 5jsdB-2wwwA:
undetectable
5jsdC-2wwwA:
undetectable		 5jsdB-2wwwA:
19.78
5jsdC-2wwwA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2www METHYLMALONIC
ACIDURIA TYPE A
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 7 GLY A 155
GLY A 153
SER A 291
THR A 158
ALA A 329
 GDP  A 600 (-3.4A)
GDP  A 600 (-3.5A)
None
GDP  A 600 (-3.3A)
GDP  A 600 (-4.0A)
 1.43A 5o96C-2wwwA:
undetectable		 5o96C-2wwwA:
22.41