SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2wwx DRRA
(Legionella
pneumophila) 		3 / 3 LEU B 493
HIS B 496
LYS B 497
 None
 1.09A 1y7iA-2wwxB:
undetectable		 1y7iA-2wwxB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 2wwx DRRA
(Legionella
pneumophila) 		5 / 11 SER B 399
GLY B 402
ASP B 457
PHE B 460
GLU B 361
 None
 1.43A 4xt7A-2wwxB:
undetectable		 4xt7A-2wwxB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 2wwx DRRA
(Legionella
pneumophila) 		5 / 12 SER B 399
GLY B 402
ALA B 404
ASP B 457
GLU B 361
 None
 1.32A 4xt8A-2wwxB:
undetectable		 4xt8A-2wwxB:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wwx DRRA
(Legionella
pneumophila) 		4 / 9 SER B 440
ALA B 372
LEU B 360
ILE B 365
 None
 0.92A 4xtaA-2wwxB:
0.5		 4xtaA-2wwxB:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 2wwx DRRA
(Legionella
pneumophila) 		5 / 9 ASN B 437
ALA B 413
ILE B 475
GLY B 470
ILE B 365
 None
 1.27A 5kr2A-2wwxB:
undetectable		 5kr2A-2wwxB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2wwx DRRA
(Legionella
pneumophila) 		4 / 5 LEU B 389
LYS B 350
LEU B 346
GLU B 347
 None
 1.33A 5weaA-2wwxB:
undetectable		 5weaA-2wwxB:
13.38