SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wxu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		3 / 3 VAL A 243
VAL A  34
TRP A 109
 None
 0.75A 1w5uA-2wxuA:
undetectable
1w5uB-2wxuA:
undetectable		 1w5uA-2wxuA:
2.59
1w5uB-2wxuA:
2.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		5 / 12 ALA A 105
ASN A 247
LEU A 121
ALA A 117
ILE A 179
 None
 0.94A 2aclA-2wxuA:
undetectable
2aclE-2wxuA:
undetectable		 2aclA-2wxuA:
21.39
2aclE-2wxuA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 6 ALA A  61
TYR A  62
ASP A  67
TYR A 127
 None
 1.36A 2pncB-2wxuA:
0.1		 2pncB-2wxuA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		5 / 11 HIS A 126
HIS A 136
HIS A 148
GLU A 152
HIS A  11
 CD  A1372 (-3.6A)
CD  A1373 (-3.6A)
CD  A1373 (-3.6A)
CD  A1373 (-2.2A)
ZN  A1375 (-3.2A)
 1.48A 2x8zA-2wxuA:
2.8		 2x8zA-2wxuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		5 / 12 PHE A 185
ILE A 179
ALA A 124
SER A 102
SER A 189
 None
 1.29A 3apwA-2wxuA:
undetectable		 3apwA-2wxuA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 5 GLN A  97
THR A  93
THR A 133
HIS A 126
 None
None
None
CD  A1372 (-3.6A)
 1.20A 3g1uC-2wxuA:
undetectable		 3g1uC-2wxuA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 6 ARG A 238
ARG A  99
GLY A 349
GLU A 257
 None
 1.09A 3k9fA-2wxuA:
undetectable
3k9fB-2wxuA:
undetectable
3k9fD-2wxuA:
undetectable		 3k9fA-2wxuA:
20.73
3k9fB-2wxuA:
20.73
3k9fD-2wxuA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 6 ILE A 262
ILE A 318
MET A 324
TRP A 290
 None
 1.45A 3welA-2wxuA:
undetectable		 3welA-2wxuA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 6 ARG A 238
HIS A 241
GLU A 245
ASP A 242
 None
CD  A1376 (-3.4A)
CD  A1376 (-2.2A)
None
 1.21A 4cevA-2wxuA:
undetectable
4cevB-2wxuA:
undetectable		 4cevA-2wxuA:
20.78
4cevB-2wxuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_B_GAIB408_0
(PROTEIN (ARGINASE))		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 5 ARG A 238
HIS A 241
GLU A 245
ASP A 242
 None
CD  A1376 (-3.4A)
CD  A1376 (-2.2A)
None
 1.19A 4cevB-2wxuA:
0.0
4cevC-2wxuA:
0.0		 4cevB-2wxuA:
20.78
4cevC-2wxuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 6 ASP A 242
ARG A 238
HIS A 241
GLU A 245
 None
None
CD  A1376 (-3.4A)
CD  A1376 (-2.2A)
 1.22A 4cevA-2wxuA:
undetectable
4cevC-2wxuA:
undetectable		 4cevA-2wxuA:
20.78
4cevC-2wxuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 6 ARG A 238
HIS A 241
GLU A 245
ASP A 242
 None
CD  A1376 (-3.4A)
CD  A1376 (-2.2A)
None
 1.20A 4cevD-2wxuA:
undetectable
4cevE-2wxuA:
undetectable		 4cevD-2wxuA:
20.78
4cevE-2wxuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 6 ARG A 238
HIS A 241
GLU A 245
ASP A 242
 None
CD  A1376 (-3.4A)
CD  A1376 (-2.2A)
None
 1.20A 4cevE-2wxuA:
undetectable
4cevF-2wxuA:
undetectable		 4cevE-2wxuA:
20.78
4cevF-2wxuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF412_0
(PROTEIN (ARGINASE))		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 5 ASP A 242
ARG A 238
HIS A 241
GLU A 245
 None
None
CD  A1376 (-3.4A)
CD  A1376 (-2.2A)
 1.21A 4cevD-2wxuA:
0.0
4cevF-2wxuA:
0.0		 4cevD-2wxuA:
20.78
4cevF-2wxuA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		3 / 3 VAL A 140
ALA A 142
PHE A  69
 None
 0.91A 4olbA-2wxuA:
undetectable		 4olbA-2wxuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		5 / 12 GLY A  18
GLN A 229
ALA A 233
TYR A 192
ILE A 164
 None
 1.23A 4pd9A-2wxuA:
2.2		 4pd9A-2wxuA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		5 / 9 ALA A 193
ILE A  14
VAL A  15
GLY A 129
SER A 102
 None
 0.96A 4r21B-2wxuA:
1.9		 4r21B-2wxuA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		3 / 3 VAL A 140
ALA A 142
PHE A  69
 None
 0.91A 4w5nA-2wxuA:
undetectable		 4w5nA-2wxuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		3 / 3 VAL A 140
ALA A 142
PHE A  69
 None
 0.92A 4z4iA-2wxuA:
undetectable		 4z4iA-2wxuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 6 PRO A  55
TYR A 235
LEU A 104
LEU A 121
 None
 1.23A 5tl8A-2wxuA:
undetectable		 5tl8A-2wxuA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		3 / 3 GLU A 108
ARG A 111
TYR A 107
 None
 0.66A 5trqB-2wxuA:
undetectable		 5trqB-2wxuA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		5 / 8 SER A  52
THR A  10
GLY A   9
ALA A  12
GLY A   3
 None
 1.45A 5vw9A-2wxuA:
undetectable		 5vw9A-2wxuA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2wxu PHOSPHOLIPASE C
(Clostridium
perfringens) 		4 / 6 GLU A  30
TYR A 237
GLY A 234
GLY A 231
 None
 0.91A 5x7pB-2wxuA:
undetectable		 5x7pB-2wxuA:
14.51