SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 5 LEU A 183
LEU A 185
SER A 111
LEU A 193
 None
 0.88A 1a4lC-2wxzA:
undetectable		 1a4lC-2wxzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 5 LEU A 443
LEU A 100
LEU A 359
GLY A  81
 None
 0.89A 1a4lC-2wxzA:
undetectable		 1a4lC-2wxzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 6 LEU A 309
ARG A 345
THR A 423
LEU A 424
 None
 1.02A 1v54A-2wxzA:
undetectable
1v54J-2wxzA:
undetectable		 1v54A-2wxzA:
22.32
1v54J-2wxzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 7 LEU A 309
ARG A 345
THR A 423
LEU A 424
 None
 0.92A 1v54N-2wxzA:
undetectable
1v54W-2wxzA:
undetectable		 1v54N-2wxzA:
22.32
1v54W-2wxzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		5 / 12 PHE A 112
GLY A 115
LEU A 147
LEU A 128
LEU A 177
 None
 1.42A 1zgyA-2wxzA:
undetectable		 1zgyA-2wxzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 6 LEU A 309
ARG A 345
THR A 423
LEU A 424
 None
 1.08A 2dysA-2wxzA:
undetectable
2dysJ-2wxzA:
undetectable		 2dysA-2wxzA:
22.32
2dysJ-2wxzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 6 LEU A 309
ARG A 345
THR A 423
LEU A 424
 None
 0.98A 2dysN-2wxzA:
undetectable
2dysW-2wxzA:
undetectable		 2dysN-2wxzA:
22.32
2dysW-2wxzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 6 LEU A 309
ARG A 345
THR A 423
LEU A 424
 None
 1.02A 2eijA-2wxzA:
undetectable
2eijJ-2wxzA:
undetectable		 2eijA-2wxzA:
22.32
2eijJ-2wxzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 6 LEU A 309
ARG A 345
THR A 423
LEU A 424
 None
 1.00A 2eilA-2wxzA:
undetectable
2eilJ-2wxzA:
undetectable		 2eilA-2wxzA:
22.32
2eilJ-2wxzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		5 / 12 TYR A 357
ILE A 395
GLY A 107
LEU A  55
VAL A 174
 None
 1.38A 2nyrB-2wxzA:
undetectable		 2nyrB-2wxzA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 8 ARG A  69
HIS A   9
GLN A  72
THR A  17
 None
 1.16A 2vxaF-2wxzA:
undetectable
2vxaG-2wxzA:
undetectable
2vxaI-2wxzA:
undetectable		 2vxaF-2wxzA:
10.80
2vxaG-2wxzA:
10.80
2vxaI-2wxzA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 6 LEU A 309
ARG A 345
THR A 423
LEU A 424
 None
 1.06A 3asnA-2wxzA:
undetectable
3asnJ-2wxzA:
undetectable		 3asnA-2wxzA:
22.32
3asnJ-2wxzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 6 LEU A 309
ARG A 345
THR A 423
LEU A 424
 None
 1.06A 3asoA-2wxzA:
undetectable
3asoJ-2wxzA:
undetectable		 3asoA-2wxzA:
22.32
3asoJ-2wxzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 7 LEU A 371
LEU A 177
VAL A 391
LEU A 378
 None
 0.95A 3g8iA-2wxzA:
undetectable		 3g8iA-2wxzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 4 LEU A 150
ALA A  77
VAL A  80
PRO A 102
 None
 1.23A 3gv1B-2wxzA:
undetectable		 3gv1B-2wxzA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		3 / 3 ARG A 354
VAL A 174
THR A 226
 None
 0.81A 3ndtA-2wxzA:
undetectable		 3ndtA-2wxzA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		5 / 12 ALA A 376
PHE A 112
SER A 111
VAL A 175
THR A 120
 None
 1.19A 4eckA-2wxzA:
undetectable		 4eckA-2wxzA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 6 ARG A 445
ALA A  98
ASP A 447
LEU A  88
 None
 0.97A 4ot2A-2wxzA:
undetectable		 4ot2A-2wxzA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		5 / 12 TYR A 248
LEU A 243
PHE A 244
LEU A 392
LEU A 232
 None
 1.34A 4rtbA-2wxzA:
undetectable		 4rtbA-2wxzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 7 ASP A 447
ARG A 445
GLY A 444
GLU A 324
 None
 1.04A 5btfA-2wxzA:
undetectable
5btfC-2wxzA:
undetectable
5btfD-2wxzA:
undetectable		 5btfA-2wxzA:
22.64
5btfC-2wxzA:
22.64
5btfD-2wxzA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		5 / 12 LEU A 372
ALA A 376
PRO A 386
LEU A 185
LEU A 177
 None
 1.13A 5ljeA-2wxzA:
undetectable		 5ljeA-2wxzA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 7 LEU A 309
ARG A 345
THR A 423
LEU A 424
 None
 0.92A 5xdqA-2wxzA:
undetectable
5xdqJ-2wxzA:
undetectable		 5xdqA-2wxzA:
22.32
5xdqJ-2wxzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		3 / 3 VAL A 174
TYR A 248
GLU A  48
 None
 0.88A 5zmqD-2wxzA:
undetectable
5zmqE-2wxzA:
undetectable		 5zmqD-2wxzA:
17.66
5zmqE-2wxzA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		5 / 12 VAL A  73
VAL A 175
PRO A 195
ILE A 200
PHE A 196
 None
 1.48A 6becA-2wxzA:
undetectable
6becB-2wxzA:
undetectable
6becC-2wxzA:
undetectable		 6becA-2wxzA:
22.22
6becB-2wxzA:
22.22
6becC-2wxzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		5 / 12 VAL A 130
PHE A 106
LEU A 378
THR A 108
GLY A 107
 None
 1.37A 6brdA-2wxzA:
undetectable		 6brdA-2wxzA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 7 LEU A 128
PHE A 245
GLY A 194
LEU A 150
 None
 0.78A 6eu9D-2wxzA:
undetectable		 6eu9D-2wxzA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 6 VAL A 301
LEU A 311
LEU A 424
LEU A 351
 None
 1.05A 6f6sA-2wxzA:
undetectable
6f6sB-2wxzA:
undetectable		 6f6sA-2wxzA:
11.85
6f6sB-2wxzA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		4 / 8 TYR A 357
VAL A 249
SER A 394
TYR A 248
 None
 0.99A 6huoC-2wxzA:
undetectable
6huoD-2wxzA:
undetectable		 6huoC-2wxzA:
13.03
6huoD-2wxzA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wxz ANGIOTENSINOGEN
(Rattus
norvegicus) 		3 / 3 ARG A 300
LEU A 310
PHE A 430
 None
 0.76A 6nknP-2wxzA:
undetectable		 6nknP-2wxzA:
19.86