SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wy0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 5 LEU C 443
LEU C 100
LEU C 359
GLY C  81
None
0.88A 1a4lC-2wy0C:
undetectable
1a4lC-2wy0C:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 ALA C 152
LEU C 150
ALA C  74
THR C  77
None
0.83A 1ie4B-2wy0C:
undetectable
1ie4D-2wy0C:
undetectable
1ie4B-2wy0C:
14.86
1ie4D-2wy0C:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 10 GLY C  81
VAL C  80
LEU C 109
LEU C 359
TYR C 357
None
1.16A 1pbcA-2wy0C:
undetectable
1pbcA-2wy0C:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
6 / 10 VAL C 130
LEU C 128
LEU C 114
VAL C 146
GLY C 143
LEU C  11
None
None
NA  C1456 ( 4.9A)
None
NA  C1456 (-4.0A)
None
1.41A 1pxxA-2wy0C:
undetectable
1pxxA-2wy0C:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
6 / 12 VAL C 130
LEU C 128
LEU C 114
VAL C 146
GLY C 143
LEU C  11
None
None
NA  C1456 ( 4.9A)
None
NA  C1456 (-4.0A)
None
1.42A 1pxxC-2wy0C:
undetectable
1pxxC-2wy0C:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 VAL C  80
THR C  77
LEU C 105
PHE C 106
None
0.99A 1s8fB-2wy0C:
undetectable
1s8fB-2wy0C:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.79A 1v54A-2wy0C:
undetectable
1v54J-2wy0C:
undetectable
1v54A-2wy0C:
21.21
1v54J-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 7 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.72A 1v54N-2wy0C:
undetectable
1v54W-2wy0C:
undetectable
1v54N-2wy0C:
21.21
1v54W-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 7 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.74A 1v55A-2wy0C:
undetectable
1v55J-2wy0C:
undetectable
1v55A-2wy0C:
21.21
1v55J-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.75A 1v55N-2wy0C:
undetectable
1v55W-2wy0C:
undetectable
1v55N-2wy0C:
21.21
1v55W-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.84A 2dyrA-2wy0C:
undetectable
2dyrJ-2wy0C:
undetectable
2dyrA-2wy0C:
21.21
2dyrJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 7 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.77A 2dyrN-2wy0C:
undetectable
2dyrW-2wy0C:
undetectable
2dyrN-2wy0C:
21.21
2dyrW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.81A 2dysA-2wy0C:
undetectable
2dysJ-2wy0C:
undetectable
2dysA-2wy0C:
21.21
2dysJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.77A 2dysN-2wy0C:
undetectable
2dysW-2wy0C:
undetectable
2dysN-2wy0C:
21.21
2dysW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.79A 2eijA-2wy0C:
undetectable
2eijJ-2wy0C:
undetectable
2eijA-2wy0C:
21.21
2eijJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.74A 2eikN-2wy0C:
undetectable
2eikW-2wy0C:
undetectable
2eikN-2wy0C:
21.21
2eikW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.78A 2eilA-2wy0C:
undetectable
2eilJ-2wy0C:
undetectable
2eilA-2wy0C:
21.21
2eilJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.76A 2eilN-2wy0C:
undetectable
2eilW-2wy0C:
undetectable
2eilN-2wy0C:
21.21
2eilW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.76A 2einA-2wy0C:
undetectable
2einJ-2wy0C:
undetectable
2einA-2wy0C:
21.21
2einJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 12 ILE C 432
ALA C 104
LEU C 150
ILE C 173
GLN C 171
None
1.05A 2h42B-2wy0C:
undetectable
2h42B-2wy0C:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_B_CHDB504_0
(FERROCHELATASE)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 ILE C  39
PRO C 233
SER C 356
MET C 230
None
1.21A 2qd3B-2wy0C:
undetectable
2qd3B-2wy0C:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 5 ILE C 280
PRO C 278
VAL C 323
PHE C 267
None
1.11A 2ygnA-2wy0C:
undetectable
2ygnA-2wy0C:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 12 GLY C  97
GLY C  94
ILE C  99
ASN C 448
LEU C 351
None
0.98A 2zbpA-2wy0C:
undetectable
2zbpA-2wy0C:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.91A 2zxwA-2wy0C:
undetectable
2zxwJ-2wy0C:
undetectable
2zxwA-2wy0C:
21.21
2zxwJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.83A 3abkA-2wy0C:
undetectable
3abkJ-2wy0C:
undetectable
3abkA-2wy0C:
21.21
3abkJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 7 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.86A 3ablA-2wy0C:
undetectable
3ablJ-2wy0C:
undetectable
3ablA-2wy0C:
21.21
3ablJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.80A 3ablN-2wy0C:
undetectable
3ablW-2wy0C:
undetectable
3ablN-2wy0C:
21.21
3ablW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.91A 3abmA-2wy0C:
undetectable
3abmJ-2wy0C:
undetectable
3abmA-2wy0C:
21.21
3abmJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.76A 3abmN-2wy0C:
undetectable
3abmW-2wy0C:
undetectable
3abmN-2wy0C:
21.21
3abmW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 7 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.78A 3ag3A-2wy0C:
undetectable
3ag3J-2wy0C:
undetectable
3ag3A-2wy0C:
21.21
3ag3J-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.74A 3ag3N-2wy0C:
0.0
3ag3W-2wy0C:
undetectable
3ag3N-2wy0C:
21.21
3ag3W-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.80A 3asnA-2wy0C:
undetectable
3asnJ-2wy0C:
undetectable
3asnA-2wy0C:
21.21
3asnJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.81A 3asoA-2wy0C:
undetectable
3asoJ-2wy0C:
undetectable
3asoA-2wy0C:
21.21
3asoJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.72A 3asoN-2wy0C:
undetectable
3asoW-2wy0C:
undetectable
3asoN-2wy0C:
21.21
3asoW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 9 THR C 159
VAL C 158
LEU C  55
ALA C 152
ALA C  59
None
1.39A 3ax7B-2wy0C:
undetectable
3ax7B-2wy0C:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 8 ARG C 306
THR C 159
LEU C  55
ALA C 152
ALA C  59
None
1.48A 3ns1L-2wy0C:
undetectable
3ns1L-2wy0C:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 12 GLY C 389
ALA C 376
LEU C 378
LEU C 244
ASN C 385
None
1.16A 3p5nA-2wy0C:
undetectable
3p5nA-2wy0C:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 12 GLY C 389
ALA C 376
LEU C 378
LEU C 244
ASN C 385
None
1.16A 3p5nB-2wy0C:
undetectable
3p5nB-2wy0C:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 311
LEU C 348
ILE C 280
MET C 255
None
0.97A 4do3B-2wy0C:
undetectable
4do3B-2wy0C:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 12 ALA C 376
PHE C 112
SER C 111
VAL C 175
THR C 120
None
1.15A 4eckA-2wy0C:
undetectable
4eckA-2wy0C:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 12 VAL C 130
LEU C 128
LEU C 114
GLY C 143
LEU C  11
None
None
NA  C1456 ( 4.9A)
NA  C1456 (-4.0A)
None
0.97A 4otyA-2wy0C:
undetectable
4otyA-2wy0C:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 12 VAL C 130
LEU C 128
LEU C 114
GLY C 143
LEU C  11
None
None
NA  C1456 ( 4.9A)
NA  C1456 (-4.0A)
None
0.94A 4rrwD-2wy0C:
undetectable
4rrwD-2wy0C:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 12 VAL C 130
LEU C 128
LEU C 114
GLY C 143
LEU C  11
None
None
NA  C1456 ( 4.9A)
NA  C1456 (-4.0A)
None
0.94A 4rrzD-2wy0C:
undetectable
4rrzD-2wy0C:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 ASP C 321
ALA C 325
LYS C  86
GLU C  90
None
EDO  C1455 ( 4.3A)
None
None
0.84A 4zbqA-2wy0C:
undetectable
4zbqA-2wy0C:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 12 GLY C 402
LEU C 311
GLY C 444
LEU C 351
THR C 254
None
1.33A 4ze1A-2wy0C:
undetectable
4ze1A-2wy0C:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 9 ALA C 307
ASP C 436
LEU C 156
LEU C 157
LEU C 169
None
1.14A 5dqfA-2wy0C:
undetectable
5dqfA-2wy0C:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
6 / 12 VAL C 130
LEU C 128
LEU C 114
VAL C 146
GLY C 143
LEU C  11
None
None
NA  C1456 ( 4.9A)
None
NA  C1456 (-4.0A)
None
1.33A 5ikqA-2wy0C:
undetectable
5ikqA-2wy0C:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
5 / 12 VAL C 130
LEU C 128
LEU C 114
GLY C 143
LEU C  11
None
None
NA  C1456 ( 4.9A)
NA  C1456 (-4.0A)
None
1.09A 5ikqB-2wy0C:
undetectable
5ikqB-2wy0C:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 6 LEU C 100
ALA C 104
SER C 394
THR C 247
None
1.15A 5l4iB-2wy0C:
undetectable
5l4iB-2wy0C:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 7 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.87A 5xdqA-2wy0C:
undetectable
5xdqJ-2wy0C:
undetectable
5xdqA-2wy0C:
21.21
5xdqJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 7 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.88A 5xdqN-2wy0C:
undetectable
5xdqW-2wy0C:
undetectable
5xdqN-2wy0C:
21.21
5xdqW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.85A 5zcpN-2wy0C:
undetectable
5zcpW-2wy0C:
undetectable
5zcpN-2wy0C:
21.21
5zcpW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 7 ASP C 321
ALA C 325
LYS C  86
GLU C  90
None
EDO  C1455 ( 4.3A)
None
None
0.76A 6ci6A-2wy0C:
undetectable
6ci6A-2wy0C:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 8 TYR C 357
VAL C 249
SER C 394
TYR C 248
None
1.03A 6huoC-2wy0C:
undetectable
6huoD-2wy0C:
undetectable
6huoC-2wy0C:
10.94
6huoD-2wy0C:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
2wy0 ANGIOTENSINOGEN
(Mus
musculus)
4 / 7 LEU C 309
ARG C 345
THR C 423
LEU C 424
None
0.97A 6nmfA-2wy0C:
undetectable
6nmfJ-2wy0C:
undetectable
6nmfA-2wy0C:
21.21
6nmfJ-2wy0C:
8.76