SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wy3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 2wy3 UNCHARACTERIZED
PROTEIN UL16
(Human
betaherpesvirus
5) 		4 / 8 SER B  33
SER B  34
SER B  31
GLN B  94
 None
NAG  B1202 (-2.8A)
None
None
 1.01A 2cmlB-2wy3B:
undetectable		 2cmlB-2wy3B:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2wy3 MHC CLASS I
POLYPEPTIDE-RELATED
SEQUENCE B
UNCHARACTERIZED
PROTEIN UL16
(Homo
sapiens;
Human
betaherpesvirus
5) 		3 / 4 SER B 127
GLY A 106
GLU A  92
 None
 0.66A 3raeA-2wy3B:
undetectable
3raeC-2wy3B:
undetectable		 3raeA-2wy3B:
13.96
3raeC-2wy3B:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 2wy3 MHC CLASS I
POLYPEPTIDE-RELATED
SEQUENCE B
(Homo
sapiens) 		4 / 5 ASP A  72
THR A  76
LEU A  73
GLU A  92
 None
 1.30A 4a3pA-2wy3A:
undetectable		 4a3pA-2wy3A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2wy3 MHC CLASS I
POLYPEPTIDE-RELATED
SEQUENCE B
(Homo
sapiens) 		3 / 3 ASN A 113
ASP A  82
ASP A  15
 None
 0.85A 4obwD-2wy3A:
undetectable		 4obwD-2wy3A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2wy3 UNCHARACTERIZED
PROTEIN UL16
(Human
betaherpesvirus
5) 		4 / 7 SER B 103
ASP B 139
ARG B 137
GLY B 136
 None
 0.97A 5btfA-2wy3B:
undetectable
5btfB-2wy3B:
undetectable
5btfC-2wy3B:
undetectable		 5btfA-2wy3B:
14.78
5btfB-2wy3B:
21.54
5btfC-2wy3B:
14.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 2wy3 MHC CLASS I
POLYPEPTIDE-RELATED
SEQUENCE B
(Homo
sapiens) 		3 / 3 PRO A  45
ARG A  35
GLU A  51
 None
ACT  A1177 (-4.0A)
None
 0.67A 5j6hA-2wy3A:
16.6		 5j6hA-2wy3A:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2wy3 UNCHARACTERIZED
PROTEIN UL16
(Human
betaherpesvirus
5) 		4 / 7 PHE B 102
ILE B  75
SER B  62
THR B 126
 None
 1.03A 5vkqA-2wy3B:
undetectable
5vkqD-2wy3B:
undetectable		 5vkqA-2wy3B:
6.64
5vkqD-2wy3B:
6.64