SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		3 / 3 TRP A 114
ARG A 102
THR A  55
 None
GOL  A 904 (-4.1A)
None
 0.95A 1df7A-2wyhA:
undetectable		 1df7A-2wyhA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 4 THR A 611
LEU A 648
LEU A 780
GLN A 306
 None
 1.23A 1fbmA-2wyhA:
undetectable		 1fbmA-2wyhA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 ASN A 739
ILE A 694
SER A  99
THR A 309
 None
 1.09A 1h7xA-2wyhA:
undetectable		 1h7xA-2wyhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 ASN A 739
ILE A 694
SER A  99
THR A 309
 None
 1.06A 1h7xB-2wyhA:
undetectable		 1h7xB-2wyhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 ASN A 739
ILE A 694
SER A  99
THR A 309
 None
 1.07A 1h7xC-2wyhA:
undetectable		 1h7xC-2wyhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 ASN A 739
ILE A 694
SER A  99
THR A 309
 None
 1.08A 1h7xD-2wyhA:
undetectable		 1h7xD-2wyhA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 9 HIS A  13
ASP A  15
HIS A 233
LEU A  89
HIS A 351
 ZN  A 902 (-3.4A)
ZN  A 902 (-2.8A)
None
None
ZN  A 902 (-3.4A)
 1.44A 1karA-2wyhA:
0.0
1karB-2wyhA:
0.0		 1karA-2wyhA:
20.79
1karB-2wyhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 9 LEU A  89
HIS A 351
HIS A  13
ASP A  15
HIS A 233
 None
ZN  A 902 (-3.4A)
ZN  A 902 (-3.4A)
ZN  A 902 (-2.8A)
None
 1.46A 1karA-2wyhA:
0.0
1karB-2wyhA:
0.0		 1karA-2wyhA:
20.79
1karB-2wyhA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		3 / 3 ASP A 239
PHE A  46
VAL A 236
 None
 0.57A 1kijB-2wyhA:
undetectable		 1kijB-2wyhA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A 780
LEU A 562
LEU A 648
ILE A 652
 None
 0.90A 1z95A-2wyhA:
undetectable		 1z95A-2wyhA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 5 LEU A 494
GLY A 513
ALA A 465
ILE A 467
 None
 0.81A 2aohB-2wyhA:
undetectable		 2aohB-2wyhA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ASP A  59
ASP A  60
ILE A  57
ILE A  76
LEU A  37
 None
 1.02A 2o4nA-2wyhA:
undetectable		 2o4nA-2wyhA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDM_B_AGGB1462_1
(INTEGRIN ALPHA-IIB
INTEGRIN BETA-3)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 12 PHE A 837
LEU A 338
TYR A 822
TYR A 868
ALA A 326
 None
GOL  A 904 (-4.7A)
None
None
None
 1.33A 2vdmA-2wyhA:
undetectable
2vdmB-2wyhA:
undetectable		 2vdmA-2wyhA:
19.07
2vdmB-2wyhA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 6 LEU A 406
THR A 808
ARG A 462
PHE A 404
ASP A 456
 None
 1.34A 2wm3A-2wyhA:
undetectable		 2wm3A-2wyhA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 ALA A 391
ALA A 389
THR A 809
PHE A 407
 None
 1.09A 2xfhA-2wyhA:
undetectable		 2xfhA-2wyhA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 7 TYR A 824
VAL A 329
TYR A 822
ILE A 392
 None
 1.35A 2xz5B-2wyhA:
undetectable
2xz5E-2wyhA:
undetectable		 2xz5B-2wyhA:
14.61
2xz5E-2wyhA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 8 ILE A 614
LEU A 646
PHE A 612
THR A 753
LEU A 755
 None
 1.23A 3abkA-2wyhA:
2.1
3abkJ-2wyhA:
undetectable		 3abkA-2wyhA:
20.26
3abkJ-2wyhA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 7 ILE A 614
LEU A 646
PHE A 612
THR A 753
 None
 1.01A 3ag2N-2wyhA:
2.1
3ag2W-2wyhA:
undetectable		 3ag2N-2wyhA:
20.26
3ag2W-2wyhA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 7 ILE A 614
LEU A 646
PHE A 612
THR A 753
 None
 1.04A 3ag4N-2wyhA:
2.1
3ag4W-2wyhA:
undetectable		 3ag4N-2wyhA:
20.26
3ag4W-2wyhA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 7 SER A 259
VAL A 118
ILE A   9
ASP A 263
 None
 1.24A 3bu1A-2wyhA:
undetectable		 3bu1A-2wyhA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MYU_A_VIBA500_1
(HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 10 HIS A  50
TYR A  87
ASP A 110
ILE A  83
GLY A  84
 None
 1.46A 3myuA-2wyhA:
0.0		 3myuA-2wyhA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 12 HIS A 349
TYR A 574
ILE A 354
GLY A 356
SER A 358
 None
 1.19A 3n8xA-2wyhA:
undetectable		 3n8xA-2wyhA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 10 ILE A  56
ASP A  52
SER A  12
LEU A  89
HIS A 351
 None
None
None
None
ZN  A 902 (-3.4A)
 1.31A 3o1xA-2wyhA:
undetectable		 3o1xA-2wyhA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 11 LEU A 676
LEU A 562
THR A 650
GLY A 545
ASP A 588
 None
 1.44A 3sfuC-2wyhA:
undetectable		 3sfuC-2wyhA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		3 / 3 PHE A 725
SER A 723
GLN A 792
 None
 0.88A 3smtA-2wyhA:
undetectable		 3smtA-2wyhA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 8 SER A 181
ASN A 180
GLY A 131
GLN A 132
 None
 0.86A 4af0A-2wyhA:
undetectable		 4af0A-2wyhA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVV_A_CPFA1081_1
(APOLIPOPROTEIN(A))		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 9 SER A 221
THR A 222
ASP A 267
ASP A 263
LEU A 186
 None
 1.40A 4bvvA-2wyhA:
undetectable		 4bvvA-2wyhA:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		3 / 3 ASN A 317
LEU A 338
PHE A 837
 None
GOL  A 904 (-4.7A)
None
 0.74A 4dajB-2wyhA:
1.9		 4dajB-2wyhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		3 / 3 TYR A  22
HIS A  26
ARG A  16
 None
 1.03A 4e7bC-2wyhA:
undetectable		 4e7bC-2wyhA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  84
GLY A 107
THR A  55
LEU A  58
SER A 117
 None
 1.08A 4f84A-2wyhA:
undetectable		 4f84A-2wyhA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 11 HIS A 349
SER A  99
LEU A 841
ASP A 110
GLY A 107
 None
 1.12A 4fogA-2wyhA:
undetectable		 4fogA-2wyhA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 11 HIS A 349
SER A  99
LEU A 841
ASP A 110
GLY A 107
 None
 1.16A 4fogC-2wyhA:
undetectable		 4fogC-2wyhA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 12 HIS A 349
SER A  99
LEU A 841
ASP A 110
GLY A 107
 None
 1.13A 4foxA-2wyhA:
undetectable		 4foxA-2wyhA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 4 LYS A 838
ALA A 836
SER A 850
THR A 835
 None
 1.45A 4i89B-2wyhA:
0.0		 4i89B-2wyhA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 5 ILE A 652
LEU A 661
GLU A 605
VAL A 417
 None
 0.88A 4nkxB-2wyhA:
undetectable		 4nkxB-2wyhA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 7 LEU A 780
LEU A 562
LEU A 648
ILE A 652
 None
 0.88A 4okwA-2wyhA:
undetectable		 4okwA-2wyhA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 PHE A 667
ASP A 566
LEU A 646
HIS A 674
 None
 1.36A 4paeA-2wyhA:
undetectable		 4paeA-2wyhA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 454
THR A 470
LEU A 510
LEU A 448
LEU A 512
 None
 1.01A 4qzuC-2wyhA:
1.7		 4qzuC-2wyhA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		3 / 3 ARG A 313
GLN A 800
GLU A 719
 None
 0.65A 4tvtA-2wyhA:
undetectable		 4tvtA-2wyhA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ASP A  34
LEU A  37
LEU A  81
LEU A  32
ILE A  33
 None
 1.09A 4x1fA-2wyhA:
undetectable		 4x1fA-2wyhA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ASP A  34
LEU A  37
LEU A  81
LEU A  32
ILE A  33
 None
 1.12A 4x1gA-2wyhA:
undetectable		 4x1gA-2wyhA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 ILE A 614
LEU A 646
PHE A 612
THR A 753
 None
 1.00A 5b1aN-2wyhA:
2.2
5b1aW-2wyhA:
undetectable		 5b1aN-2wyhA:
20.26
5b1aW-2wyhA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		3 / 3 ASN A 317
LEU A 338
PHE A 837
 None
GOL  A 904 (-4.7A)
None
 0.82A 5dsgA-2wyhA:
1.9		 5dsgA-2wyhA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 HIS A 351
ASP A 125
HIS A  13
TRP A  18
 ZN  A 902 (-3.4A)
ZN  A 902 (-3.5A)
ZN  A 902 (-3.4A)
None
 1.43A 5m45A-2wyhA:
0.0		 5m45A-2wyhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 HIS A 351
ASP A 125
HIS A  13
TRP A  18
 ZN  A 902 (-3.4A)
ZN  A 902 (-3.5A)
ZN  A 902 (-3.4A)
None
 1.42A 5m45D-2wyhA:
0.5		 5m45D-2wyhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 HIS A 351
ASP A 125
HIS A  13
TRP A  18
 ZN  A 902 (-3.4A)
ZN  A 902 (-3.5A)
ZN  A 902 (-3.4A)
None
 1.42A 5m45G-2wyhA:
0.4		 5m45G-2wyhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 HIS A 351
ASP A 125
HIS A  13
TRP A  18
 ZN  A 902 (-3.4A)
ZN  A 902 (-3.5A)
ZN  A 902 (-3.4A)
None
 1.42A 5m45J-2wyhA:
0.0		 5m45J-2wyhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 8 LEU A  62
VAL A  64
HIS A  26
LEU A  37
ILE A  30
 None
 1.40A 5v0vA-2wyhA:
1.6		 5v0vA-2wyhA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		3 / 3 TYR A 192
ASP A  52
ASP A 125
 None
None
ZN  A 902 (-3.5A)
 0.86A 5x6yA-2wyhA:
undetectable		 5x6yA-2wyhA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 7 ASN A 348
ARG A 369
GLU A  17
ARG A  16
 None
 0.85A 6b8kA-2wyhA:
undetectable		 6b8kA-2wyhA:
6.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 8 ASN A 348
ARG A 369
GLU A  17
ARG A  16
 None
 0.76A 6b94A-2wyhA:
undetectable		 6b94A-2wyhA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		5 / 9 HIS A 349
ILE A  83
LEU A  51
ARG A  16
ASP A  60
 None
 0.97A 6c2mC-2wyhA:
undetectable		 6c2mC-2wyhA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 4 ARG A 495
GLU A 419
GLU A 605
ARG A 653
 None
 0.95A 6fk2A-2wyhA:
undetectable		 6fk2A-2wyhA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 ILE A 173
ALA A 144
MET A 137
ASP A  92
 None
 1.17A 6hu9m-2wyhA:
2.5
6hu9q-2wyhA:
undetectable		 6hu9m-2wyhA:
20.78
6hu9q-2wyhA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 2wyh ALPHA-MANNOSIDASE
(Streptococcus
pyogenes) 		4 / 6 LEU A  94
HIS A 363
TYR A 574
GLU A 573
 None
 1.08A 6pahA-2wyhA:
undetectable		 6pahA-2wyhA:
16.51