SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		4 / 5 ASP A 226
HIS A 281
HIS A 117
HIS A 122
 MN  A1341 (-3.6A)
MN  A1341 (-3.6A)
None
MN  A1341 (-3.4A)
 1.11A 1ei6A-2wymA:
undetectable		 1ei6A-2wymA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IHI_A_IU5A326_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 10 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
None
GOL  A1343 (-3.9A)
GOL  A1343 ( 4.9A)
None
 1.21A 1ihiA-2wymA:
0.5		 1ihiA-2wymA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		3 / 3 LYS A  90
ASP A 226
CYH A  45
 None
MN  A1341 (-3.6A)
MN  A1341 ( 4.9A)
 0.91A 2br4F-2wymA:
undetectable		 2br4F-2wymA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 12 ASP A 226
GLY A  47
LEU A  43
ASP A 283
SER A 248
 MN  A1341 (-3.6A)
None
None
None
None
 1.22A 2nv4A-2wymA:
undetectable		 2nv4A-2wymA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		4 / 7 ILE A 107
ARG A 108
GLY A  21
TRP A  20
 GOL  A1343 (-3.9A)
None
None
None
 1.14A 2pnjB-2wymA:
undetectable		 2pnjB-2wymA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		4 / 9 ILE A 107
ALA A 128
VAL A 131
CYH A 135
 GOL  A1343 (-3.9A)
None
None
None
 1.04A 2vufB-2wymA:
undetectable		 2vufB-2wymA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 12 MET A  40
PHE A 321
ILE A  48
PHE A  38
ASP A 328
 None
 1.24A 3aocC-2wymA:
undetectable		 3aocC-2wymA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		3 / 3 GLU A  53
GLY A  55
THR A  56
 None
 0.59A 3iazA-2wymA:
undetectable		 3iazA-2wymA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 9 PHE A  38
PHE A 280
ILE A  48
ALA A 245
VAL A  60
 None
 1.26A 3me6C-2wymA:
undetectable		 3me6C-2wymA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 12 ALA A 115
ASP A  61
ILE A 107
PRO A 104
THR A 116
 None
None
GOL  A1343 (-3.9A)
None
None
 1.11A 3nrrA-2wymA:
undetectable		 3nrrA-2wymA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 12 ALA A 115
ASP A  61
ILE A 107
PRO A 104
THR A 116
 None
None
GOL  A1343 (-3.9A)
None
None
 1.12A 3nrrB-2wymA:
undetectable		 3nrrB-2wymA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 8 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
None
GOL  A1343 (-3.9A)
GOL  A1343 ( 4.9A)
None
 1.19A 4jq1B-2wymA:
undetectable		 4jq1B-2wymA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 10 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
None
GOL  A1343 (-3.9A)
GOL  A1343 ( 4.9A)
None
 1.26A 4jtqA-2wymA:
undetectable		 4jtqA-2wymA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_B_FLPB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 9 VAL A 113
VAL A 131
ILE A 107
TRP A  49
LEU A  43
 None
None
GOL  A1343 (-3.9A)
GOL  A1343 ( 4.9A)
None
 1.25A 4jtqB-2wymA:
0.5		 4jtqB-2wymA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		4 / 4 ILE A 110
ASN A  57
ILE A 175
VAL A 172
 None
GOL  A1343 ( 4.5A)
None
None
 1.24A 4uy87-2wymA:
undetectable		 4uy87-2wymA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		3 / 3 SER A 224
ALA A 245
VAL A 244
 None
 0.43A 4x20C-2wymA:
undetectable		 4x20C-2wymA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		4 / 5 VAL A 131
VAL A 156
ARG A 160
PHE A 141
 None
 1.02A 5d4nA-2wymA:
undetectable
5d4nC-2wymA:
undetectable		 5d4nA-2wymA:
16.34
5d4nC-2wymA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		4 / 8 ASP A 226
HIS A 117
TRP A 285
HIS A 281
 MN  A1341 (-3.6A)
None
None
MN  A1341 (-3.6A)
 0.90A 5nekB-2wymA:
undetectable		 5nekB-2wymA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		4 / 6 LEU A  50
VAL A  60
LEU A 221
GLU A 176
 None
 0.94A 5tudD-2wymA:
undetectable		 5tudD-2wymA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 10 TRP A 154
PHE A  62
ALA A 128
PHE A 141
VAL A 113
 None
 1.50A 6hu9C-2wymA:
undetectable		 6hu9C-2wymA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG
(Escherichia
coli) 		5 / 11 GLY A  47
GLY A  44
LEU A 102
VAL A 101
ASP A 124
 None
 1.24A 6i5zD-2wymA:
undetectable		 6i5zD-2wymA:
21.14