SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wyo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 PHE A  18
LEU A   6
MET A   1
 None
 0.76A 1mx1D-2wyoA:
undetectable		 1mx1D-2wyoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 THR A 457
GLU A 464
ASP A  89
 None
 0.78A 1nt2A-2wyoA:
undetectable		 1nt2A-2wyoA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 THR A  43
SER A 531
SER A 495
VAL A 497
 None
 0.74A 2hdnE-2wyoA:
undetectable
2hdnF-2wyoA:
undetectable
2hdnH-2wyoA:
undetectable		 2hdnE-2wyoA:
4.86
2hdnF-2wyoA:
19.82
2hdnH-2wyoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 SER A 495
VAL A 497
THR A  43
SER A 531
 None
 0.74A 2hdnF-2wyoA:
undetectable
2hdnG-2wyoA:
undetectable
2hdnH-2wyoA:
undetectable		 2hdnF-2wyoA:
19.82
2hdnG-2wyoA:
4.86
2hdnH-2wyoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 THR A  43
SER A 531
SER A 495
VAL A 497
 None
 0.78A 2hdnI-2wyoA:
undetectable
2hdnJ-2wyoA:
undetectable
2hdnL-2wyoA:
undetectable		 2hdnI-2wyoA:
4.86
2hdnJ-2wyoA:
19.82
2hdnL-2wyoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 SER A 495
VAL A 497
THR A  43
SER A 531
 None
 0.75A 2hdnJ-2wyoA:
undetectable
2hdnK-2wyoA:
undetectable
2hdnL-2wyoA:
undetectable		 2hdnJ-2wyoA:
19.82
2hdnK-2wyoA:
4.86
2hdnL-2wyoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 MET A  60
VAL A 206
GLU A 199
 None
 0.85A 2x9gA-2wyoA:
undetectable		 2x9gA-2wyoA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		4 / 8 VAL A 207
VAL A 206
GLY A 204
PRO A 156
 None
 0.95A 3bjwA-2wyoA:
undetectable		 3bjwA-2wyoA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		5 / 11 ALA A 152
ARG A 119
ILE A 499
GLY A 526
SER A 201
 None
GSH  A1556 (-3.1A)
None
None
None
 1.33A 3bpxA-2wyoA:
undetectable
3bpxB-2wyoA:
undetectable		 3bpxA-2wyoA:
13.80
3bpxB-2wyoA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		5 / 10 VAL A 320
GLY A 116
ILE A 503
ALA A 217
ILE A 350
 None
 0.94A 3ekpB-2wyoA:
undetectable		 3ekpB-2wyoA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		5 / 10 VAL A 320
GLY A 116
ILE A 503
ALA A 217
ILE A 350
 None
 1.00A 3ekpC-2wyoA:
undetectable		 3ekpC-2wyoA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		5 / 9 VAL A 320
GLY A 116
ILE A 503
ALA A 217
ILE A 350
 None
 1.03A 3ektB-2wyoA:
undetectable		 3ektB-2wyoA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 LEU A 115
TYR A 357
PHE A 521
ILE A 503
GLY A 501
 None
 1.17A 3n8xA-2wyoA:
undetectable		 3n8xA-2wyoA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 VAL A 320
VAL A 277
LEU A 113
ASP A 213
 None
 0.97A 3rgfA-2wyoA:
undetectable		 3rgfA-2wyoA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 LYS A 223
SER A 303
GLN A 306
 None
 0.65A 3si7A-2wyoA:
undetectable		 3si7A-2wyoA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 ALA A 321
ARG A 284
ILE A 283
LEU A 115
VAL A 215
 None
 1.26A 4azwA-2wyoA:
4.6		 4azwA-2wyoA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 PHE A  92
GLY A  94
LEU A 342
PHE A 332
LEU A 359
 None
 1.28A 4xldA-2wyoA:
undetectable		 4xldA-2wyoA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 ILE A 318
VAL A 260
PHE A 323
ILE A 350
ALA A 349
 None
 1.11A 5n0xA-2wyoA:
undetectable		 5n0xA-2wyoA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 ILE A 318
VAL A 260
PHE A 323
ILE A 350
ALA A 349
 None
 1.08A 5n4iA-2wyoA:
undetectable		 5n4iA-2wyoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		4 / 8 PRO A 353
THR A 361
THR A 146
PRO A 329
 None
 1.30A 5x2sI-2wyoA:
undetectable
5x2sJ-2wyoA:
undetectable
5x2sK-2wyoA:
undetectable		 5x2sI-2wyoA:
14.98
5x2sJ-2wyoA:
15.66
5x2sK-2wyoA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2wyo GLUTATHIONE
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 PHE A 381
LEU A 376
ALA A 380
THR A 120
 None
 0.92A 6f88A-2wyoA:
undetectable		 6f88A-2wyoA:
10.82