SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wyr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 6 ILE A  31
LYS A 185
ALA A 183
VAL A  47
 None
 1.01A 1hk1A-2wyrA:
undetectable		 1hk1A-2wyrA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 8 GLU A 330
ASN A 271
LEU A 323
LEU A 298
 None
 1.00A 1hwiB-2wyrA:
undetectable		 1hwiB-2wyrA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 8 GLU A 330
ASN A 271
LEU A 323
LEU A 298
 None
 1.00A 1hwiC-2wyrA:
undetectable		 1hwiC-2wyrA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 8 ALA A 211
GLU A  54
ALA A 223
THR A 295
 None
 0.85A 1ie4B-2wyrA:
undetectable
1ie4D-2wyrA:
undetectable		 1ie4B-2wyrA:
17.61
1ie4D-2wyrA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RNR_A_DAHA208_1
(RIBONUCLEOTIDE
REDUCTASE R1 PROTEIN)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		5 / 11 HIS A 306
LEU A 208
GLU A 204
ILE A  65
GLU A 205
 CO  A1332 (-3.5A)
None
CO  A1333 ( 3.7A)
None
CO  A1332 (-2.1A)
 1.33A 1rnrA-2wyrA:
undetectable		 1rnrA-2wyrA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		3 / 3 GLU A 137
GLU A 144
LEU A 105
 None
 0.55A 1v8bA-2wyrA:
undetectable		 1v8bA-2wyrA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 6 ALA A 211
ASN A  44
ILE A  46
ASP A  40
 None
 1.00A 1yc2A-2wyrA:
undetectable		 1yc2A-2wyrA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 5 ALA A 211
ASN A  44
ILE A  46
ASP A  40
 None
 0.92A 1yc2D-2wyrA:
undetectable		 1yc2D-2wyrA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 5 ALA A 211
ASN A  44
ILE A  46
ASP A  40
 None
 1.09A 2h4jA-2wyrA:
undetectable		 2h4jA-2wyrA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		5 / 10 ALA A 286
PHE A  58
PHE A 224
LEU A 331
THR A 284
 None
 1.25A 2w3aB-2wyrA:
undetectable		 2w3aB-2wyrA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
ASP A 227
SER A 228
ASP A 173
 CO  A1333 (-3.4A)
CO  A1333 (-2.1A)
CO  A1333 (-3.6A)
CO  A1333 ( 4.7A)
 1.10A 2xadA-2wyrA:
undetectable		 2xadA-2wyrA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
ASP A 227
SER A 228
ASP A 173
 CO  A1333 (-3.4A)
CO  A1333 (-2.1A)
CO  A1333 (-3.6A)
CO  A1333 ( 4.7A)
 1.09A 2xadB-2wyrA:
undetectable		 2xadB-2wyrA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
ASP A 227
SER A 228
ASP A 173
 CO  A1333 (-3.4A)
CO  A1333 (-2.1A)
CO  A1333 (-3.6A)
CO  A1333 ( 4.7A)
 1.08A 2xadC-2wyrA:
undetectable		 2xadC-2wyrA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 8 HIS A  61
ASP A 227
SER A 228
ASP A 173
 CO  A1333 (-3.4A)
CO  A1333 (-2.1A)
CO  A1333 (-3.6A)
CO  A1333 ( 4.7A)
 1.08A 2xadD-2wyrA:
undetectable		 2xadD-2wyrA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 7 VAL A  47
MET A  62
ILE A  27
ILE A  28
 None
 1.02A 3hgxA-2wyrA:
undetectable		 3hgxA-2wyrA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 8 ASP A  88
LEU A  67
LEU A  91
SER A 307
 None
 0.94A 3lm8B-2wyrA:
undetectable
3lm8D-2wyrA:
undetectable		 3lm8B-2wyrA:
21.59
3lm8D-2wyrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		4 / 6 PHE A 175
ILE A 226
ALA A  60
THR A 284
 None
 1.06A 3mdrA-2wyrA:
undetectable		 3mdrA-2wyrA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		5 / 9 ASN A  44
GLY A 210
GLY A  43
PHE A 213
ASP A  40
 None
 1.34A 4h2gA-2wyrA:
undetectable		 4h2gA-2wyrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		3 / 3 LEU A  57
MET A  59
ASP A  36
 None
 0.80A 4j7xB-2wyrA:
undetectable		 4j7xB-2wyrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		3 / 3 ARG A  29
GLU A  30
PHE A  10
 None
 0.92A 4kszA-2wyrA:
undetectable		 4kszA-2wyrA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		6 / 11 HIS A  61
ASP A 172
GLU A 204
GLU A 205
GLY A 282
HIS A 306
 CO  A1333 (-3.4A)
CO  A1333 ( 2.4A)
CO  A1333 ( 3.7A)
CO  A1332 (-2.1A)
None
CO  A1332 (-3.5A)
 0.65A 4pqaA-2wyrA:
24.5		 4pqaA-2wyrA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		6 / 11 HIS A  61
ASP A 172
GLU A 204
GLY A 281
GLY A 282
HIS A 306
 CO  A1333 (-3.4A)
CO  A1333 ( 2.4A)
CO  A1333 ( 3.7A)
None
None
CO  A1332 (-3.5A)
 0.78A 4pqaA-2wyrA:
24.5		 4pqaA-2wyrA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		5 / 11 HIS A  61
ASP A 172
GLU A 205
GLY A 281
HIS A 306
 CO  A1333 (-3.4A)
CO  A1333 ( 2.4A)
CO  A1332 (-2.1A)
None
CO  A1332 (-3.5A)
 0.54A 4pqaA-2wyrA:
24.5		 4pqaA-2wyrA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		6 / 11 HIS A  61
GLU A 204
ARG A 248
GLY A 281
GLY A 282
HIS A 306
 CO  A1333 (-3.4A)
CO  A1333 ( 3.7A)
None
None
None
CO  A1332 (-3.5A)
 1.06A 4pqaA-2wyrA:
24.5		 4pqaA-2wyrA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		6 / 11 HIS A  61
GLU A 204
GLU A 205
ARG A 248
GLY A 282
HIS A 306
 CO  A1333 (-3.4A)
CO  A1333 ( 3.7A)
CO  A1332 (-2.1A)
None
None
CO  A1332 (-3.5A)
 1.00A 4pqaA-2wyrA:
24.5		 4pqaA-2wyrA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		3 / 3 ASN A 216
ALA A 215
ARG A 292
 None
 0.75A 5cvtB-2wyrA:
5.5		 5cvtB-2wyrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 2wyr COBALT-ACTIVATED
PEPTIDASE TET1
(Pyrococcus
horikoshii) 		3 / 3 MET A  62
GLU A  25
ARG A  24
 None
 1.00A 5tjyA-2wyrA:
undetectable		 5tjyA-2wyrA:
24.19