SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 2wz8 CELLULOSOME PROTEIN
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A  87
ILE A  41
TYR A 130
GLY A 132
 None
 1.13A 1maaB-2wz8A:
undetectable
1maaD-2wz8A:
undetectable		 1maaB-2wz8A:
14.82
1maaD-2wz8A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 2wz8 CELLULOSOME PROTEIN
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum) 		5 / 11 PHE A 129
ILE A  41
THR A  19
ASN A  52
VAL A  66
 None
 1.22A 2gl0B-2wz8A:
undetectable
2gl0C-2wz8A:
undetectable		 2gl0B-2wz8A:
17.65
2gl0C-2wz8A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 2wz8 CELLULOSOME PROTEIN
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A  20
ASN A  18
ARG A  26
 None
 0.75A 2qhfA-2wz8A:
undetectable		 2qhfA-2wz8A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2wz8 CELLULOSOME PROTEIN
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ALA A  24
VAL A  25
GLN A  27
 None
 0.72A 3of4B-2wz8A:
undetectable		 3of4B-2wz8A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 2wz8 CELLULOSOME PROTEIN
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASP A 117
THR A 113
ILE A  90
VAL A 118
ILE A 146
 None
 1.41A 4eb6B-2wz8A:
undetectable
4eb6C-2wz8A:
undetectable		 4eb6B-2wz8A:
15.11
4eb6C-2wz8A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2wz8 CELLULOSOME PROTEIN
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A  18
ILE A 146
LEU A 120
ILE A 144
ASN A 140
 None
 1.06A 4o1eA-2wz8A:
undetectable		 4o1eA-2wz8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 2wz8 CELLULOSOME PROTEIN
DOCKERIN TYPE I
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A  18
ILE A 146
LEU A 120
ILE A 144
ASN A 140
 None
 1.05A 4o1eB-2wz8A:
undetectable		 4o1eB-2wz8A:
19.71