SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wzf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 LEU A  47
ALA A  53
ILE A  56
ILE A  38
LEU A  35
 None
 1.08A 1tw4A-2wzfA:
undetectable		 1tw4A-2wzfA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 5 TRP A 234
ILE A 453
LEU A 208
ALA A 313
 None
 0.88A 1xvaA-2wzfA:
undetectable
1xvaB-2wzfA:
undetectable		 1xvaA-2wzfA:
19.85
1xvaB-2wzfA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 ALA A 313
TRP A 234
ILE A 453
LEU A 208
 None
 0.88A 1xvaA-2wzfA:
undetectable
1xvaB-2wzfA:
undetectable		 1xvaA-2wzfA:
19.85
1xvaB-2wzfA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		3 / 3 GLN A 504
HIS A 467
ARG A 468
 None
 0.53A 1zlqA-2wzfA:
undetectable		 1zlqA-2wzfA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		3 / 3 THR A 478
PRO A 476
PRO A 480
 None
 0.71A 2d55C-2wzfA:
undetectable		 2d55C-2wzfA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 PHE A 239
ALA A 452
SER A 448
ALA A 456
GLY A 451
 None
None
BGC  A1526 ( 4.9A)
None
None
 1.23A 2igtC-2wzfA:
undetectable		 2igtC-2wzfA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		3 / 3 ASN A 293
ASN A 271
ARG A 502
 BGC  A1526 (-3.0A)
None
None
 0.72A 2rlcA-2wzfA:
undetectable		 2rlcA-2wzfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 ASN A 301
MET A 269
PHE A 130
GLY A 242
GLY A  89
 None
 1.50A 2y6rC-2wzfA:
undetectable		 2y6rC-2wzfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 8 ILE A 297
ASN A 293
ARG A 502
ASP A 246
 None
BGC  A1526 (-3.0A)
None
BGC  A1526 (-2.7A)
 1.08A 2zw9B-2wzfA:
undetectable		 2zw9B-2wzfA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 ALA A  53
LEU A  74
HIS A  83
LEU A  12
ALA A  19
 None
 1.13A 3dfrA-2wzfA:
undetectable		 3dfrA-2wzfA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 ASN A  33
GLN A  29
LEU A  28
THR A  23
LEU A  35
 None
 1.20A 3fsuA-2wzfA:
undetectable		 3fsuA-2wzfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 PHE A 117
GLY A 264
GLY A 265
ALA A 489
TRP A 503
 None
 1.22A 3i5uA-2wzfA:
undetectable		 3i5uA-2wzfA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 10 PHE A 495
ASP A 295
SER A 497
LEU A 156
ILE A 168
 None
BGC  A1526 (-4.3A)
None
None
None
 1.47A 3ko0O-2wzfA:
undetectable
3ko0P-2wzfA:
undetectable
3ko0Q-2wzfA:
0.0
3ko0R-2wzfA:
0.0		 3ko0O-2wzfA:
11.39
3ko0P-2wzfA:
11.39
3ko0Q-2wzfA:
11.39
3ko0R-2wzfA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 11 MET A 269
PHE A 130
GLY A 242
GLY A  89
ASN A 126
 None
 1.15A 3v3nA-2wzfA:
undetectable		 3v3nA-2wzfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 11 MET A 269
PHE A 130
GLY A 242
GLY A  89
ASN A 126
 None
 1.15A 3v3nD-2wzfA:
undetectable		 3v3nD-2wzfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 5 ALA A 298
MET A 308
THR A 305
PHE A 130
 None
 1.25A 3vasB-2wzfA:
undetectable		 3vasB-2wzfA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 11 ASN A 301
MET A 269
PHE A 130
GLY A 242
GLY A  89
 None
 1.48A 4a99C-2wzfA:
1.0		 4a99C-2wzfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 11 MET A 269
PHE A 130
GLY A 242
GLY A  89
ASN A 126
 None
 1.19A 4a99D-2wzfA:
undetectable		 4a99D-2wzfA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 LEU A 196
LEU A 170
ILE A 247
MET A 148
 None
None
UDP  A1525 (-4.6A)
None
 0.95A 4do3B-2wzfA:
undetectable		 4do3B-2wzfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 GLY A 223
GLY A 222
GLU A 215
ILE A 348
 None
 0.95A 4fglD-2wzfA:
undetectable		 4fglD-2wzfA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 8 ASN A 455
ALA A 452
PRO A 450
LEU A 316
 None
None
BGC  A1526 (-4.5A)
None
 0.77A 4jjkA-2wzfA:
2.4		 4jjkA-2wzfA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K88_A_HFGA602_0
(PROLINE--TRNA LIGASE)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 PHE A 486
VAL A 115
PRO A 113
THR A 477
GLU A 110
 None
 1.47A 4k88A-2wzfA:
undetectable		 4k88A-2wzfA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 SER A 206
GLU A 237
VAL A 312
THR A 311
 None
 1.38A 4lnxA-2wzfA:
undetectable		 4lnxA-2wzfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 ASN A 506
ILE A 275
SER A 274
GLY A 273
ALA A 501
 None
 1.33A 4xt8A-2wzfA:
undetectable		 4xt8A-2wzfA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 5 SER A 173
SER A 174
SER A 175
SER A 201
 None
 1.11A 5hswA-2wzfA:
undetectable		 5hswA-2wzfA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 7 SER A 519
PRO A 522
TYR A 440
SER A 229
 UDP  A1525 (-2.8A)
None
None
UDP  A1525 (-2.8A)
 1.22A 5l1fC-2wzfA:
2.2		 5l1fC-2wzfA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 4 GLU A  94
PRO A  92
ILE A  95
LEU A  90
 None
 1.21A 5m45A-2wzfA:
undetectable		 5m45A-2wzfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 4 GLU A  94
PRO A  92
ILE A  95
LEU A  90
 None
 1.26A 5m45J-2wzfA:
0.1		 5m45J-2wzfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 ILE A  44
ALA A  77
ILE A  56
ALA A  55
GLU A  49
 None
 1.05A 5vceA-2wzfA:
undetectable		 5vceA-2wzfA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 10 TYR A 107
ILE A  78
ILE A  38
ILE A  95
ASN A  98
 None
 1.29A 5vkqA-2wzfA:
undetectable
5vkqD-2wzfA:
undetectable		 5vkqA-2wzfA:
14.59
5vkqD-2wzfA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 10 ILE A  95
ASN A  98
TYR A 107
ILE A  78
ILE A  38
 None
 1.28A 5vkqA-2wzfA:
undetectable
5vkqB-2wzfA:
undetectable		 5vkqA-2wzfA:
14.59
5vkqB-2wzfA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 10 ILE A  95
ASN A  98
TYR A 107
ILE A  78
ILE A  38
 None
 1.26A 5vkqC-2wzfA:
undetectable
5vkqD-2wzfA:
undetectable		 5vkqC-2wzfA:
14.59
5vkqD-2wzfA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 8 GLY A 264
ARG A 304
GLN A 306
ASP A 302
 None
 0.87A 5vlmB-2wzfA:
undetectable		 5vlmB-2wzfA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 2wzf GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 LEU A  35
LEU A  20
ILE A  44
ALA A  19
ILE A  82
 None
 0.97A 5xiwB-2wzfA:
undetectable		 5xiwB-2wzfA:
10.10