SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wzg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 VAL A 290
MET A 272
VAL A 115
ASN A 462
 None
 0.95A 1e06A-2wzgA:
undetectable		 1e06A-2wzgA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 PRO A  84
PHE A  16
LEU A  35
ILE A  78
 None
 1.22A 1sbrA-2wzgA:
undetectable
1sbrB-2wzgA:
undetectable		 1sbrA-2wzgA:
16.38
1sbrB-2wzgA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 5 TRP A 234
ILE A 453
LEU A 208
ALA A 313
 None
 0.84A 1xvaA-2wzgA:
undetectable
1xvaB-2wzgA:
undetectable		 1xvaA-2wzgA:
18.84
1xvaB-2wzgA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 ALA A 313
TRP A 234
ILE A 453
LEU A 208
 None
 0.84A 1xvaA-2wzgA:
undetectable
1xvaB-2wzgA:
undetectable		 1xvaA-2wzgA:
18.84
1xvaB-2wzgA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 GLU A 445
GLY A 449
ASN A 224
ALA A 452
ALA A 456
 None
UPG  A1525 ( 3.7A)
None
None
None
 1.20A 2br4B-2wzgA:
undetectable		 2br4B-2wzgA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		3 / 3 THR A 478
PRO A 476
PRO A 480
 None
 0.70A 2d55C-2wzgA:
undetectable		 2d55C-2wzgA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		3 / 3 ARG A 340
GLY A 372
PRO A 373
 None
 0.72A 2hreD-2wzgA:
undetectable		 2hreD-2wzgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 PHE A 239
ALA A 452
SER A 448
ALA A 456
GLY A 451
 None
None
UPG  A1525 ( 4.9A)
None
None
 1.23A 2igtC-2wzgA:
undetectable		 2igtC-2wzgA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 LEU A 403
LEU A 406
MET A 427
VAL A 426
MET A 429
 None
 1.20A 2q7iA-2wzgA:
undetectable		 2q7iA-2wzgA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 ASN A 301
MET A 269
PHE A 130
GLY A 242
GLY A  89
 None
 1.47A 2y6rC-2wzgA:
undetectable		 2y6rC-2wzgA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		3 / 3 PRO A 522
PHE A 439
LYS A 441
 None
 1.26A 3bjwG-2wzgA:
undetectable		 3bjwG-2wzgA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 11 MET A 269
PHE A 130
GLY A 242
GLY A  89
ASN A 126
 None
 1.15A 3v3nA-2wzgA:
undetectable		 3v3nA-2wzgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 11 MET A 269
PHE A 130
GLY A 242
GLY A  89
ASN A 126
 None
 1.15A 3v3nD-2wzgA:
undetectable		 3v3nD-2wzgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 5 ALA A 298
MET A 308
THR A 305
PHE A 130
 None
 1.28A 3vasB-2wzgA:
undetectable		 3vasB-2wzgA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 LEU A 403
LEU A 406
MET A 427
VAL A 426
MET A 429
 None
 1.23A 3zqtA-2wzgA:
undetectable		 3zqtA-2wzgA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 11 ASN A 301
MET A 269
PHE A 130
GLY A 242
GLY A  89
 None
 1.47A 4a99C-2wzgA:
undetectable		 4a99C-2wzgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 11 MET A 269
PHE A 130
GLY A 242
GLY A  89
ASN A 126
 None
 1.20A 4a99D-2wzgA:
undetectable		 4a99D-2wzgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 LEU A 196
LEU A 170
ILE A 247
MET A 148
 None
None
UPG  A1525 (-4.6A)
None
 0.94A 4do3B-2wzgA:
undetectable		 4do3B-2wzgA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 GLY A 223
GLY A 222
GLU A 215
ILE A 348
 None
 0.95A 4fglD-2wzgA:
undetectable		 4fglD-2wzgA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 10 ALA A 289
ILE A 276
GLY A 273
ILE A 500
VAL A 507
 None
 1.08A 4j5jB-2wzgA:
undetectable		 4j5jB-2wzgA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 8 ASN A 455
ALA A 452
PRO A 450
LEU A 316
 None
None
UPG  A1525 (-4.9A)
None
 0.84A 4jjkA-2wzgA:
4.0		 4jjkA-2wzgA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 6 SER A 206
GLU A 237
VAL A 312
THR A 311
 None
 1.36A 4lnxA-2wzgA:
undetectable		 4lnxA-2wzgA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 5 SER A 173
SER A 174
SER A 175
SER A 201
 None
 0.97A 5hswA-2wzgA:
undetectable		 5hswA-2wzgA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 4 GLU A  94
PRO A  92
ILE A  95
LEU A  90
 None
 1.15A 5m45A-2wzgA:
undetectable		 5m45A-2wzgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		4 / 4 GLU A  94
PRO A  92
ILE A  95
LEU A  90
 None
 1.20A 5m45J-2wzgA:
0.0		 5m45J-2wzgA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		3 / 3 GLU A 288
HIS A 467
ARG A 468
 None
 0.80A 5uunA-2wzgA:
undetectable		 5uunA-2wzgA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		5 / 12 ILE A  44
ALA A  77
ILE A  56
ALA A  55
GLU A  49
 None
 0.92A 5vceA-2wzgA:
undetectable		 5vceA-2wzgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2wzg GLUCOSYLTRANSFERASE
(Legionella
pneumophila) 		3 / 3 ARG A 286
ILE A 276
SER A 277
 None
 0.76A 5zw2A-2wzgA:
undetectable		 5zw2A-2wzgA:
23.16