SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wzm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 MET A 261
LEU A 264
LEU A 267
LEU A 203
LEU A 231
 None
 1.27A 1gwrA-2wzmA:
undetectable		 1gwrA-2wzmA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 204
TRP A 227
MET A 261
LEU A 267
 NA7  A1284 (-4.8A)
None
None
None
 1.41A 2oz7A-2wzmA:
undetectable		 2oz7A-2wzmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A  82
ALA A  98
ALA A  63
VAL A  64
ASP A  34
 None
 1.08A 2yvlD-2wzmA:
undetectable		 2yvlD-2wzmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A  54
GLY A  59
LEU A  32
SER A  33
ALA A  37
 None
 0.94A 3dcmX-2wzmA:
2.0		 3dcmX-2wzmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 MET A 261
LEU A 264
LEU A 172
LEU A 203
LEU A 231
 None
 1.18A 3erdA-2wzmA:
undetectable		 3erdA-2wzmA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 MET A 261
LEU A 264
LEU A 267
LEU A 203
LEU A 231
 None
 1.24A 3hm1B-2wzmA:
undetectable		 3hm1B-2wzmA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 MET A 261
LEU A 264
LEU A 267
LEU A 203
LEU A 231
 None
 1.25A 3ollA-2wzmA:
undetectable		 3ollA-2wzmA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 226
ARG A 218
ILE A 229
 None
 0.92A 4b7qA-2wzmA:
undetectable		 4b7qA-2wzmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 226
ARG A 218
ILE A 229
 None
 0.86A 4b7qC-2wzmA:
undetectable		 4b7qC-2wzmA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A 121
GLY A 119
LEU A  84
HIS A 116
GLY A  90
 None
 1.24A 4blvB-2wzmA:
undetectable		 4blvB-2wzmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 THR A  54
LEU A 107
LEU A 105
GLY A  65
 None
 0.84A 4c9nA-2wzmA:
undetectable		 4c9nA-2wzmA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 THR A  54
LEU A 107
LEU A 105
VAL A  41
 None
 0.76A 4c9nA-2wzmA:
undetectable		 4c9nA-2wzmA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 THR A 271
LEU A 224
GLN A 230
LEU A 231
 None
 1.13A 4ib4A-2wzmA:
undetectable		 4ib4A-2wzmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 7 VAL A  64
ILE A  52
ARG A  50
ILE A  27
ALA A  44
 None
 1.33A 4lv9A-2wzmA:
2.9		 4lv9A-2wzmA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 THR A 271
LEU A 224
GLN A 230
LEU A 231
 None
 1.24A 4nc3A-2wzmA:
undetectable		 4nc3A-2wzmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 MET A 261
LEU A 264
ASN A 265
LEU A 224
GLN A 230
 None
 1.39A 4p6xA-2wzmA:
undetectable		 4p6xA-2wzmA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 THR A  54
ALA A  55
THR A  82
TYR A 113
 None
 1.05A 5ecmA-2wzmA:
undetectable		 5ecmA-2wzmA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 THR A  54
ALA A  55
THR A  82
TYR A 113
 None
 0.98A 5ecoA-2wzmA:
undetectable		 5ecoA-2wzmA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLY A  30
THR A  54
ASN A  60
 NA7  A1284 ( 3.8A)
None
None
 0.69A 5odiG-2wzmA:
undetectable		 5odiG-2wzmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 GLN A  89
GLY A 119
GLN A 178
TRP A 117
 None
 1.10A 5vlmC-2wzmA:
undetectable		 5vlmC-2wzmA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 254
LEU A 225
ALA A 213
LEU A 264
LEU A 256
 None
 1.27A 5x23A-2wzmA:
undetectable		 5x23A-2wzmA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2wzm ALDO-KETO REDUCTASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 TYR A 113
GLN A 169
GLU A  61
ALA A  97
 None
 1.26A 6djzB-2wzmA:
undetectable		 6djzB-2wzmA:
23.73