SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wzo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2wzo TRANSFORMING GROWTH
FACTOR BETA
REGULATOR 1
(Homo
sapiens) 		3 / 3 CYH A 232
PRO A 228
ASP A 254
 None
 1.00A 3hlwB-2wzoA:
undetectable		 3hlwB-2wzoA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 2wzo TRANSFORMING GROWTH
FACTOR BETA
REGULATOR 1
(Homo
sapiens) 		3 / 3 SER A 276
MET A 279
ASP A 254
 GOL  A1325 (-2.6A)
None
None
 0.93A 4mm4B-2wzoA:
undetectable		 4mm4B-2wzoA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2wzo TRANSFORMING GROWTH
FACTOR BETA
REGULATOR 1
(Homo
sapiens) 		5 / 9 ASP A 201
PRO A 213
VAL A 214
GLY A 204
PHE A 205
 None
 1.32A 4mmbA-2wzoA:
undetectable		 4mmbA-2wzoA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E2I_A_DMEA605_1
(ACETYLCHOLINESTERASE)		 2wzo TRANSFORMING GROWTH
FACTOR BETA
REGULATOR 1
(Homo
sapiens) 		4 / 6 ASP A 207
TYR A 317
PHE A 296
TYR A 212
 None
None
GOL  A1326 (-4.8A)
GOL  A1326 ( 4.6A)
 1.41A 5e2iA-2wzoA:
undetectable		 5e2iA-2wzoA:
12.72