SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wzr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		3 / 3 ASP 1  76
TYR 1 120
GLU 1 190
 None
 0.82A 1vm1A-2wzr1:
undetectable		 1vm1A-2wzr1:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		3 / 3 TYR 3 125
TYR 2 100
GLY 3 183
 None
 0.72A 3eteB-2wzr3:
undetectable
3eteD-2wzr3:
undetectable
3eteF-2wzr3:
undetectable		 3eteB-2wzr3:
20.65
3eteD-2wzr3:
20.65
3eteF-2wzr3:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		4 / 6 PHE 3 212
TYR 3 101
VAL 3 204
PHE 3  81
 None
 1.06A 3ltwA-2wzr3:
undetectable		 3ltwA-2wzr3:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 10 VAL 3 204
PHE 3  81
ALA 3  80
VAL 3 185
VAL 3 160
 None
 0.94A 3me6A-2wzr3:
undetectable		 3me6A-2wzr3:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 9 VAL 3 204
PHE 3  81
ALA 3  80
VAL 3 185
VAL 3 160
 None
 0.94A 3me6C-2wzr3:
undetectable		 3me6C-2wzr3:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 9 VAL 3 204
PHE 3  81
ALA 3  80
VAL 3 185
VAL 3 160
 None
 0.87A 3me6D-2wzr3:
undetectable		 3me6D-2wzr3:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 10 ALA 1 122
LEU 1 127
LEU 1  54
ALA 1 189
VAL 1  63
 None
 1.15A 3r9cA-2wzr1:
undetectable		 3r9cA-2wzr1:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		4 / 5 TYR 3 125
GLN 3 182
GLY 3 183
SER 3 180
 None
 1.31A 4fu8A-2wzr3:
undetectable		 4fu8A-2wzr3:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		3 / 3 HIS 2  64
VAL 2 123
LEU 2 179
 None
 0.63A 4m2vA-2wzr2:
undetectable		 4m2vA-2wzr2:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 12 LEU 2 140
LEU 2 132
LYS 2 131
TYR 2  36
THR 2 178
 None
 1.15A 4q0dA-2wzr2:
undetectable		 4q0dA-2wzr2:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 12 LEU 2 140
LEU 2 132
LYS 2 131
TYR 2  36
THR 2 178
 None
 1.15A 4q0dB-2wzr2:
undetectable		 4q0dB-2wzr2:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 12 LEU 2 140
LEU 2 132
LYS 2 131
TYR 2  36
THR 2 178
 None
 1.15A 4q0dC-2wzr2:
undetectable		 4q0dC-2wzr2:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 12 LEU 2 140
LEU 2 132
LYS 2 131
TYR 2  36
THR 2 178
 None
 1.15A 4q0dD-2wzr2:
undetectable		 4q0dD-2wzr2:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 12 LEU 2 140
LEU 2 132
LYS 2 131
TYR 2  36
THR 2 178
 None
 1.15A 4q0dE-2wzr2:
undetectable		 4q0dE-2wzr2:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		3 / 3 MET 3  91
GLN 3 100
TYR 3 170
 None
 1.13A 4udcA-2wzr3:
undetectable		 4udcA-2wzr3:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 12 LEU 2 179
VAL 2 107
ILE 2 158
LEU 2 140
LEU 2 122
 None
 1.34A 4yvpB-2wzr2:
undetectable		 4yvpB-2wzr2:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		4 / 6 HIS 2  64
VAL 2 202
LEU 2  83
THR 2  85
 None
 1.28A 5ogjA-2wzr2:
undetectable		 5ogjA-2wzr2:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGJ_B_ACTB305_0
(CARBONIC ANHYDRASE
13)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		4 / 6 HIS 2  64
VAL 2 202
LEU 2  83
THR 2  85
 None
 1.26A 5ogjB-2wzr2:
undetectable		 5ogjB-2wzr2:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_A_ACTA307_0
(CARBONIC ANHYDRASE
13)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		4 / 5 HIS 2  64
VAL 2 202
LEU 2  83
THR 2  85
 None
 1.25A 5ohhA-2wzr2:
undetectable		 5ohhA-2wzr2:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OHH_B_ACTB311_0
(CARBONIC ANHYDRASE
13)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		4 / 6 HIS 2  64
VAL 2 202
LEU 2  83
THR 2  85
 None
 1.28A 5ohhB-2wzr2:
undetectable		 5ohhB-2wzr2:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 10 VAL 2 123
ALA 2 156
LEU 2 148
ASN 2 149
ASN 2 153
 None
 1.11A 5x6yB-2wzr2:
undetectable		 5x6yB-2wzr2:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2wzr POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 12 SER 3  92
VAL 3 202
LEU 3 105
PHE 3  77
LEU 3  79
 None
 1.28A 6a93B-2wzr3:
undetectable		 6a93B-2wzr3:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2wzr POLYPROTEIN
POLYPROTEIN
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		4 / 6 GLY 1 102
ASN 1 104
ASP 1 103
ARG 3 220
 None
 1.13A 6dwdA-2wzr1:
undetectable
6dwdC-2wzr1:
undetectable		 6dwdA-2wzr1:
18.23
6dwdC-2wzr1:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2wzr POLYPROTEIN
POLYPROTEIN
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		4 / 5 GLY 1 102
ASN 1 104
ASP 1 103
ARG 3 220
 None
 1.13A 6dwdB-2wzr1:
undetectable
6dwdD-2wzr1:
undetectable		 6dwdB-2wzr1:
18.23
6dwdD-2wzr1:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2wzr POLYPROTEIN
POLYPROTEIN
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		4 / 5 ARG 3 220
GLY 1 102
ASN 1 104
ASP 1 103
 None
 1.12A 6dwjB-2wzr3:
undetectable
6dwjD-2wzr3:
undetectable		 6dwjB-2wzr3:
17.55
6dwjD-2wzr3:
17.55