SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 333
GLU A 378
PHE A 316
HIS A 327
 None
 0.98A 1ax9A-2wzsA:
undetectable		 1ax9A-2wzsA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_A_RBFA301_1
(PROTEIN (FLAVODOXIN))		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 THR A 227
THR A 185
GLY A 183
TYR A 199
 None
 0.92A 1bu5A-2wzsA:
undetectable		 1bu5A-2wzsA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 608
TRP A 623
HIS A 599
ILE A 604
PHE A 568
 None
GOL  A 803 ( 4.6A)
None
None
None
 1.35A 1fkfA-2wzsA:
undetectable		 1fkfA-2wzsA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 608
TRP A 623
HIS A 599
ILE A 604
PHE A 568
 None
GOL  A 803 ( 4.6A)
None
None
None
 1.37A 1fkjA-2wzsA:
undetectable		 1fkjA-2wzsA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ALA A 132
GLU A 133
LEU A 131
VAL A 129
 None
 0.86A 1hk2A-2wzsA:
undetectable		 1hk2A-2wzsA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 11 ASN A 198
ARG A 391
GLY A 191
GLY A 190
PHE A 196
 None
 1.49A 1ho5A-2wzsA:
undetectable		 1ho5A-2wzsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 VAL A 121
VAL A  26
ILE A  47
LEU A 286
 None
 0.88A 1iepB-2wzsA:
undetectable		 1iepB-2wzsA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 569
VAL A 567
TRP A 537
 None
 0.73A 1nt6A-2wzsA:
undetectable		 1nt6A-2wzsA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 569
VAL A 567
TRP A 537
 None
 0.73A 1nt6B-2wzsA:
undetectable		 1nt6B-2wzsA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 311
SER A 649
MET A  30
TYR A 639
TRP A 282
 None
 1.47A 1osvB-2wzsA:
0.0		 1osvB-2wzsA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 127
PHE A  79
ILE A  76
TYR A  69
 None
 1.42A 1qltA-2wzsA:
undetectable		 1qltA-2wzsA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 127
PHE A  79
ILE A  76
TYR A  69
 None
 1.42A 1qltB-2wzsA:
0.0		 1qltB-2wzsA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A  80
ILE A 249
THR A 138
 None
 0.82A 1rx3A-2wzsA:
undetectable		 1rx3A-2wzsA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_A_ACTA601_0
(VANILLYL-ALCOHOL
OXIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 127
PHE A  79
ILE A  76
TYR A  69
 None
 1.48A 1vaoA-2wzsA:
0.0		 1vaoA-2wzsA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAO_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 127
PHE A  79
ILE A  76
TYR A  69
 None
 1.48A 1vaoB-2wzsA:
0.0		 1vaoB-2wzsA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 TRP A 527
TYR A 579
GLY A 641
SER A  39
 None
 1.16A 2a3cA-2wzsA:
undetectable		 2a3cA-2wzsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 TRP A 527
TYR A 579
GLY A 641
SER A  39
 None
 1.06A 2a3cB-2wzsA:
undetectable		 2a3cB-2wzsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 608
TRP A 623
HIS A 599
ILE A 604
PHE A 568
 None
GOL  A 803 ( 4.6A)
None
None
None
 1.33A 2fkeA-2wzsA:
undetectable		 2fkeA-2wzsA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 4 ASP A 164
ASP A 107
ASP A 167
GLY A 217
 None
 1.48A 2igtC-2wzsA:
undetectable		 2igtC-2wzsA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A  52
TRP A  56
MET A  53
SER A 251
 None
 1.20A 2o5yH-2wzsA:
undetectable
2o5yL-2wzsA:
2.1		 2o5yH-2wzsA:
14.48
2o5yL-2wzsA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A  89
GLU A 585
HIS A 584
ASP A 642
ASP A 644
 None
MVL  A 801 (-4.0A)
None
None
CA  A 800 ( 2.8A)
 1.36A 2pgfA-2wzsA:
undetectable		 2pgfA-2wzsA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A 387
TYR A  92
ILE A  89
ASP A 343
 None
 1.23A 2x45B-2wzsA:
undetectable		 2x45B-2wzsA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 SER A 387
TYR A  92
ILE A  89
ASP A 343
 None
 1.23A 2x45C-2wzsA:
undetectable		 2x45C-2wzsA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 751
THR A 666
PHE A 350
 None
 0.71A 2x91A-2wzsA:
undetectable		 2x91A-2wzsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 LEU A 550
TRP A 472
TYR A 613
 None
 1.00A 3aicG-2wzsA:
undetectable		 3aicG-2wzsA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 PRO A 124
ILE A  47
PRO A 142
TYR A 126
 None
None
None
GOL  A 804 ( 3.8A)
 1.22A 3d9lA-2wzsA:
3.4
3d9lY-2wzsA:
undetectable		 3d9lA-2wzsA:
10.50
3d9lY-2wzsA:
2.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A 534
PHE A 574
ALA A 462
GLU A 466
ALA A 598
 None
 0.98A 3g88A-2wzsA:
undetectable		 3g88A-2wzsA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A 534
PHE A 574
ALA A 462
GLU A 466
ALA A 598
 None
 0.99A 3g88B-2wzsA:
undetectable		 3g88B-2wzsA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 534
PHE A 574
ALA A 462
GLU A 466
ALA A 598
 None
 0.96A 3g89A-2wzsA:
undetectable		 3g89A-2wzsA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A 534
PHE A 574
ALA A 462
GLU A 466
ALA A 598
 None
 0.96A 3g89B-2wzsA:
undetectable		 3g89B-2wzsA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 534
PHE A 574
ALA A 462
GLU A 466
ALA A 598
 None
 0.94A 3g8bA-2wzsA:
undetectable		 3g8bA-2wzsA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 534
PHE A 574
ALA A 462
GLU A 466
ALA A 598
 None
 0.96A 3g8bB-2wzsA:
undetectable		 3g8bB-2wzsA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 470
ARG A 439
ARG A 351
 None
 1.02A 3k37A-2wzsA:
undetectable		 3k37A-2wzsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 115
ILE A  76
GLY A 119
HIS A 117
 None
 1.38A 3r0lD-2wzsA:
undetectable		 3r0lD-2wzsA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 354
PRO A 355
LEU A 681
ILE A 289
ALA A 650
 None
 1.38A 4a83A-2wzsA:
undetectable		 4a83A-2wzsA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 537
TRP A 541
THR A 540
 None
 1.50A 4bboB-2wzsA:
2.2		 4bboB-2wzsA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A  80
ILE A 249
THR A 138
 None
 0.77A 4gh8A-2wzsA:
undetectable		 4gh8A-2wzsA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 PRO A  99
MET A 140
PHE A  79
ILE A  76
 None
 0.97A 4j4vC-2wzsA:
undetectable		 4j4vC-2wzsA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 361
ASN A 685
LEU A 681
ILE A 289
LEU A 286
 GOL  A 802 (-4.5A)
None
None
None
None
 1.47A 4k36B-2wzsA:
undetectable		 4k36B-2wzsA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 11 TYR A 361
ASN A 685
LEU A 681
ILE A 289
LEU A 286
 GOL  A 802 (-4.5A)
None
None
None
None
 1.38A 4k37B-2wzsA:
undetectable		 4k37B-2wzsA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 642
PRO A  87
SER A  34
SER A  39
 None
 1.27A 4k7gB-2wzsA:
undetectable		 4k7gB-2wzsA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 351
ASP A 644
GLY A 600
GLU A 588
 None
CA  A 800 ( 2.8A)
None
None
 0.87A 4koeA-2wzsA:
undetectable
4koeB-2wzsA:
2.6
4koeD-2wzsA:
undetectable		 4koeA-2wzsA:
21.49
4koeB-2wzsA:
21.49
4koeD-2wzsA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 390
TRP A 385
SER A 379
 None
MVL  A 801 (-3.9A)
None
 1.13A 4lrhD-2wzsA:
undetectable		 4lrhD-2wzsA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A  47
TYR A  44
LEU A 311
PHE A 312
 None
 0.78A 4qopC-2wzsA:
undetectable		 4qopC-2wzsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A  81
HIS A  83
ARG A 314
 None
 1.04A 4qyqA-2wzsA:
undetectable		 4qyqA-2wzsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 GLN A  81
HIS A  83
ARG A 314
 None
 1.01A 4qyqB-2wzsA:
undetectable		 4qyqB-2wzsA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 HIS A 720
ASP A 667
ARG A 719
PRO A 661
 None
 0.76A 4uhxA-2wzsA:
undetectable		 4uhxA-2wzsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 HIS A 720
ASP A 667
ARG A 719
PRO A 664
 None
 1.06A 4uhxA-2wzsA:
undetectable		 4uhxA-2wzsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 HIS A 720
ASP A 667
ARG A 719
PRO A 661
 None
 0.76A 4uhxA-2wzsA:
undetectable		 4uhxA-2wzsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 HIS A 720
ASP A 667
ARG A 719
PRO A 664
 None
 1.06A 4uhxA-2wzsA:
undetectable		 4uhxA-2wzsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 351
GLY A 600
GLU A 588
SER A 542
 None
 0.91A 4z3oA-2wzsA:
undetectable
4z3oB-2wzsA:
2.7		 4z3oA-2wzsA:
21.58
4z3oB-2wzsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 372
TYR A 376
PRO A 383
LEU A 403
 None
 0.85A 4z4fA-2wzsA:
undetectable		 4z4fA-2wzsA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 7 ARG A 351
ASP A 644
GLY A 600
GLU A 588
SER A 542
 None
CA  A 800 ( 2.8A)
None
None
None
 1.01A 4z53A-2wzsA:
undetectable
4z53B-2wzsA:
2.3		 4z53A-2wzsA:
21.58
4z53B-2wzsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 402
ALA A 406
LEU A 357
ASN A 358
PHE A 346
 None
 1.29A 4zo1X-2wzsA:
undetectable		 4zo1X-2wzsA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 644
GLY A 600
GLU A 588
ARG A 351
 CA  A 800 ( 2.8A)
None
None
None
 1.02A 5bs8A-2wzsA:
undetectable
5bs8B-2wzsA:
undetectable
5bs8C-2wzsA:
undetectable		 5bs8A-2wzsA:
20.13
5bs8B-2wzsA:
16.74
5bs8C-2wzsA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 644
GLY A 600
GLU A 588
ARG A 351
 CA  A 800 ( 2.8A)
None
None
None
 1.00A 5btdA-2wzsA:
undetectable
5btdB-2wzsA:
undetectable
5btdC-2wzsA:
undetectable		 5btdA-2wzsA:
20.13
5btdB-2wzsA:
16.74
5btdC-2wzsA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 351
ASP A 644
GLY A 600
GLU A 588
 None
CA  A 800 ( 2.8A)
None
None
 0.99A 5btdA-2wzsA:
undetectable
5btdC-2wzsA:
undetectable
5btdD-2wzsA:
undetectable		 5btdA-2wzsA:
20.13
5btdC-2wzsA:
20.13
5btdD-2wzsA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 644
GLY A 600
GLU A 588
ARG A 351
 CA  A 800 ( 2.8A)
None
None
None
 0.96A 5btfA-2wzsA:
undetectable
5btfB-2wzsA:
undetectable
5btfC-2wzsA:
undetectable		 5btfA-2wzsA:
19.65
5btfB-2wzsA:
16.74
5btfC-2wzsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 351
ASP A 644
GLY A 600
GLU A 588
 None
CA  A 800 ( 2.8A)
None
None
 0.99A 5btfA-2wzsA:
undetectable
5btfC-2wzsA:
undetectable
5btfD-2wzsA:
undetectable		 5btfA-2wzsA:
19.65
5btfC-2wzsA:
19.65
5btfD-2wzsA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 SER A 542
GLY A 600
GLU A 588
ARG A 351
 None
 1.18A 5cdqA-2wzsA:
2.6
5cdqB-2wzsA:
undetectable
5cdqC-2wzsA:
undetectable		 5cdqA-2wzsA:
20.11
5cdqB-2wzsA:
13.89
5cdqC-2wzsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 351
ASP A 644
GLY A 600
GLU A 588
 None
CA  A 800 ( 2.8A)
None
None
 0.89A 5cdqA-2wzsA:
2.6
5cdqC-2wzsA:
undetectable
5cdqD-2wzsA:
undetectable		 5cdqA-2wzsA:
20.11
5cdqC-2wzsA:
20.11
5cdqD-2wzsA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 351
SER A 542
GLY A 600
GLU A 588
 None
 0.94A 5cdqA-2wzsA:
2.6
5cdqC-2wzsA:
undetectable
5cdqD-2wzsA:
undetectable		 5cdqA-2wzsA:
20.11
5cdqC-2wzsA:
20.11
5cdqD-2wzsA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 5 SER A 542
GLY A 600
GLU A 588
ARG A 351
 None
 1.04A 5cdqR-2wzsA:
2.4
5cdqS-2wzsA:
undetectable
5cdqT-2wzsA:
undetectable		 5cdqR-2wzsA:
20.11
5cdqS-2wzsA:
13.89
5cdqT-2wzsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		6 / 12 GLY A 119
PHE A 237
ILE A 235
PHE A 153
GLY A 236
PHE A  79
 None
 1.28A 5eqbA-2wzsA:
undetectable		 5eqbA-2wzsA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A  83
PHE A  55
ALA A  48
SER A  96
ILE A  97
 None
 1.42A 5iwuA-2wzsA:
1.1		 5iwuA-2wzsA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 THR A  72
TYR A  69
THR A  60
VAL A 129
 None
 1.21A 5ov9B-2wzsA:
undetectable		 5ov9B-2wzsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 372
TYR A 376
PRO A 383
LEU A 403
 None
 0.89A 5t7bA-2wzsA:
undetectable		 5t7bA-2wzsA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 402
LEU A 403
LEU A 423
PRO A 383
 None
 1.01A 5u4sA-2wzsA:
undetectable		 5u4sA-2wzsA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 402
LEU A 403
LEU A 423
PRO A 383
 None
 1.02A 5u4sB-2wzsA:
undetectable		 5u4sB-2wzsA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 370
ALA A 406
GLY A 410
TYR A 407
 None
 1.09A 5uxdA-2wzsA:
undetectable		 5uxdA-2wzsA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 419
VAL A 413
PHE A 346
ALA A 386
GLY A 389
 None
 1.10A 5uxdB-2wzsA:
undetectable		 5uxdB-2wzsA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 ILE A 583
ASN A 601
CYH A 640
 None
MVL  A 801 ( 3.4A)
None
 0.82A 6bp4A-2wzsA:
undetectable		 6bp4A-2wzsA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A 527
GLU A 533
GLU A 588
 None
MVL  A 801 (-3.0A)
None
 0.92A 6fhwA-2wzsA:
6.3		 6fhwA-2wzsA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 343
MET A  53
TYR A  92
ASN A  54
 None
 0.71A 6giqL-2wzsA:
undetectable
6giqP-2wzsA:
undetectable
6giqT-2wzsA:
undetectable		 6giqL-2wzsA:
21.60
6giqP-2wzsA:
15.41
6giqT-2wzsA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 10 THR A 344
GLY A 646
LEU A 353
VAL A 653
CYH A 305
 None
 1.41A 6gnfC-2wzsA:
undetectable		 6gnfC-2wzsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 184
VAL A 162
ILE A 181
ALA A 231
 None
 0.87A 6hd6B-2wzsA:
undetectable		 6hd6B-2wzsA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 12 ASN A  54
ASN A 262
ILE A 254
VAL A 335
PHE A 316
 None
 1.48A 6j21A-2wzsA:
undetectable		 6j21A-2wzsA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 405
GLY A 665
TYR A 469
ASP A 348
THR A 349
 None
None
None
MVL  A 801 (-2.9A)
None
 1.47A 6mn1A-2wzsA:
0.0		 6mn1A-2wzsA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 405
GLY A 665
TYR A 469
ASP A 348
THR A 349
 None
None
None
MVL  A 801 (-2.9A)
None
 1.49A 6mn1B-2wzsA:
0.0		 6mn1B-2wzsA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 719
TYR A 717
GLU A 668
ASP A 667
 None
 1.18A 6mn5E-2wzsA:
undetectable		 6mn5E-2wzsA:
9.08