SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2wzv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A 116
TYR A 113
THR A 131
TYR A 137
 None
 1.12A 1afsA-2wzvA:
undetectable		 1afsA-2wzvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A 116
TYR A 113
THR A 131
TYR A 137
 None
 1.12A 1afsB-2wzvA:
undetectable		 1afsB-2wzvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A  45
LEU A 166
ALA A 143
TYR A 209
ILE A 175
 None
 1.16A 1mx8A-2wzvA:
undetectable		 1mx8A-2wzvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A 183
SER A 184
TYR A 186
LEU A  77
 None
 1.16A 1xz1A-2wzvA:
undetectable		 1xz1A-2wzvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 4 LEU A 183
SER A 184
TYR A 186
LEU A  77
 None
 1.16A 1xz3A-2wzvA:
undetectable		 1xz3A-2wzvA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A  21
ARG A  20
ILE A  22
 None
 0.57A 2xn5B-2wzvA:
undetectable		 2xn5B-2wzvA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 TYR A 162
ALA A 163
LEU A 166
ALA A 143
 None
 0.67A 3b6hA-2wzvA:
undetectable		 3b6hA-2wzvA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 189
LEU A 182
GLN A 127
LEU A 134
ARG A 135
 None
FMN  A 801 (-4.3A)
None
None
None
 1.03A 3fsuA-2wzvA:
undetectable		 3fsuA-2wzvA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 201
MET A 159
TYR A  92
 None
 0.91A 4p6xG-2wzvA:
undetectable		 4p6xG-2wzvA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 VAL A 190
VAL A 196
GLY A 195
PHE A 146
 None
 1.07A 5d4nA-2wzvA:
1.2
5d4nC-2wzvA:
1.3		 5d4nA-2wzvA:
17.17
5d4nC-2wzvA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 2wzv NFNB PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLN A 180
LEU A  73
LEU A  77
THR A 131
 None
 1.12A 5hs6A-2wzvA:
undetectable		 5hs6A-2wzvA:
26.19