SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2x05'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 ALA A  63
VAL A  65
TRP A  81
 None
 0.89A 1av2C-2x05A:
undetectable
1av2D-2x05A:
undetectable		 1av2C-2x05A:
1.74
1av2D-2x05A:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 5 LYS A 719
LEU A 722
ALA A 702
LEU A 700
 None
 1.18A 1eta2-2x05A:
3.5		 1eta2-2x05A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 4 LYS A 719
LEU A 722
ALA A 702
LEU A 700
 None
 1.16A 1f86B-2x05A:
3.6		 1f86B-2x05A:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 8 GLY A 333
SER A 460
THR A 413
ASP A 404
 None
None
None
CD  A1904 (-2.1A)
 0.86A 1m4iA-2x05A:
undetectable		 1m4iA-2x05A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 ASP A 552
ARG A 885
ASP A 837
ILE A 886
ALA A 807
 None
 1.28A 1oltA-2x05A:
undetectable		 1oltA-2x05A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 10 GLY A 214
VAL A 143
GLY A 142
THR A  89
VAL A 188
 None
None
None
CD  A1907 (-3.4A)
None
 1.23A 1pwyE-2x05A:
undetectable		 1pwyE-2x05A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 10 GLY A 214
VAL A 143
GLY A 142
THR A  89
VAL A 188
 None
None
None
CD  A1907 (-3.4A)
None
 1.29A 1v3qE-2x05A:
undetectable		 1v3qE-2x05A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 SER A 613
ALA A 592
GLY A 590
LEU A 593
PHE A 606
 None
 1.26A 1vpoH-2x05A:
4.9
1vpoL-2x05A:
5.2		 1vpoH-2x05A:
13.04
1vpoL-2x05A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 ALA A  63
VAL A  65
TRP A  81
 None
 0.84A 1w5uC-2x05A:
undetectable
1w5uD-2x05A:
undetectable		 1w5uC-2x05A:
1.74
1w5uD-2x05A:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 LEU A 238
ASN A 239
LEU A 292
LEU A 295
 None
 0.89A 1z95A-2x05A:
undetectable		 1z95A-2x05A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 5 LEU A 171
PHE A 186
VAL A 162
ALA A 157
 None
 1.19A 2cizA-2x05A:
undetectable		 2cizA-2x05A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 ASN A 585
TYR A 782
SER A 580
 None
 0.73A 2gvcB-2x05A:
undetectable		 2gvcB-2x05A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 ASN A 585
TYR A 782
SER A 580
 None
 0.72A 2gvcE-2x05A:
undetectable		 2gvcE-2x05A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 PHE A 656
ALA A 377
ASN A 385
GLY A 361
LEU A 644
 None
 1.09A 2hw2A-2x05A:
undetectable		 2hw2A-2x05A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 TRP A  81
ALA A  63
VAL A  65
 None
 0.74A 2izqA-2x05A:
undetectable
2izqB-2x05A:
undetectable		 2izqA-2x05A:
1.74
2izqB-2x05A:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 TYR A 525
GLN A 679
ARG A 627
HIS A 682
 None
 1.44A 2qmqA-2x05A:
undetectable		 2qmqA-2x05A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 GLY A 416
GLY A 362
PHE A 402
PHE A 403
 None
 1.02A 2qx6A-2x05A:
undetectable
2qx6B-2x05A:
undetectable		 2qx6A-2x05A:
13.00
2qx6B-2x05A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 ASN A 854
LEU A 868
THR A 820
VAL A 821
 None
 1.18A 2uz2A-2x05A:
undetectable		 2uz2A-2x05A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 PHE A 622
ALA A 406
THR A 413
VAL A 391
GLY A 361
 None
 1.14A 2ve3B-2x05A:
undetectable		 2ve3B-2x05A:
17.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZS_A_GCSA1902_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		11 / 12 ILE A 202
ASP A 203
GLU A 394
SER A 468
ASP A 469
MET A 512
TYR A 516
GLU A 541
TRP A 642
TRP A 653
TRP A 781
 X05  A1900 (-3.5A)
X05  A1900 (-2.7A)
X05  A1900 (-2.6A)
X05  A1900 (-3.6A)
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
X05  A1900 (-2.5A)
X05  A1900 (-4.3A)
None
None
 0.35A 2vzsA-2x05A:
70.1		 2vzsA-2x05A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZS_B_GCSB1903_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		11 / 12 ILE A 202
ASP A 203
GLU A 394
SER A 468
ASP A 469
MET A 512
TYR A 516
GLU A 541
TRP A 642
TRP A 653
TRP A 781
 X05  A1900 (-3.5A)
X05  A1900 (-2.7A)
X05  A1900 (-2.6A)
X05  A1900 (-3.6A)
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
X05  A1900 (-2.5A)
X05  A1900 (-4.3A)
None
None
 0.35A 2vzsB-2x05A:
69.7		 2vzsB-2x05A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZV_A_GCSA1899_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		10 / 11 ILE A 202
ASP A 203
TRP A 204
GLU A 394
ASP A 469
MET A 512
TYR A 516
TRP A 642
TRP A 653
TRP A 781
 X05  A1900 (-3.5A)
X05  A1900 (-2.7A)
X05  A1900 (-4.2A)
X05  A1900 (-2.6A)
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
X05  A1900 (-4.3A)
None
None
 0.41A 2vzvA-2x05A:
69.1		 2vzvA-2x05A:
99.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZV_A_GCSA1900_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 6 GLU A 431
ASP A 469
MET A 512
TYR A 516
TRP A 781
 None
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
None
 0.53A 2vzvA-2x05A:
69.1		 2vzvA-2x05A:
99.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZV_B_GCSB1899_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		10 / 11 ILE A 202
ASP A 203
TRP A 204
GLU A 394
ASP A 469
MET A 512
TYR A 516
TRP A 642
TRP A 653
TRP A 781
 X05  A1900 (-3.5A)
X05  A1900 (-2.7A)
X05  A1900 (-4.2A)
X05  A1900 (-2.6A)
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
X05  A1900 (-4.3A)
None
None
 0.44A 2vzvB-2x05A:
69.4		 2vzvB-2x05A:
99.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VZV_B_GCSB1900_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 6 GLU A 431
ASP A 469
MET A 512
TYR A 516
TRP A 781
 None
X05  A1900 (-3.2A)
X05  A1900 (-3.4A)
X05  A1900 (-3.5A)
None
 0.55A 2vzvB-2x05A:
69.4		 2vzvB-2x05A:
99.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 TYR A 667
LEU A 386
ASN A 385
ASP A 378
 None
 1.40A 2w98A-2x05A:
0.0
2w98B-2x05A:
0.0		 2w98A-2x05A:
15.60
2w98B-2x05A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 8 ARG A 230
SER A 275
VAL A 261
VAL A 253
 None
 1.16A 2y05A-2x05A:
undetectable
2y05B-2x05A:
undetectable		 2y05A-2x05A:
15.39
2y05B-2x05A:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 5 PHE A 402
PHE A 403
LEU A 455
PHE A 464
 None
 1.34A 2y69P-2x05A:
undetectable
2y69W-2x05A:
undetectable		 2y69P-2x05A:
14.08
2y69W-2x05A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 LEU A 823
ALA A 807
LEU A 868
THR A 819
 None
 1.03A 3cfqA-2x05A:
3.4		 3cfqA-2x05A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 MET A 306
LEU A 727
THR A 637
ILE A 358
GLN A 348
 None
 1.21A 3g4lD-2x05A:
undetectable		 3g4lD-2x05A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 ALA A  63
VAL A  65
TRP A  81
 None
 0.73A 3l8lA-2x05A:
undetectable
3l8lB-2x05A:
undetectable		 3l8lA-2x05A:
1.74
3l8lB-2x05A:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 ALA A  63
VAL A  65
TRP A  81
 None
 0.81A 3l8lC-2x05A:
undetectable
3l8lD-2x05A:
undetectable		 3l8lC-2x05A:
1.74
3l8lD-2x05A:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 10 VAL A 177
ILE A 173
ALA A 185
ILE A  54
VAL A 221
 None
 1.05A 3me6A-2x05A:
undetectable		 3me6A-2x05A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 11 TRP A 201
GLY A 362
ASN A 645
GLU A 541
ILE A 640
 None
None
None
X05  A1900 (-2.5A)
None
 1.32A 3owxA-2x05A:
undetectable
3owxB-2x05A:
undetectable		 3owxA-2x05A:
12.67
3owxB-2x05A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 4 SER A 463
GLY A 638
GLU A 621
 None
 0.68A 3raeA-2x05A:
undetectable
3raeC-2x05A:
undetectable		 3raeA-2x05A:
18.25
3raeC-2x05A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDR_A_210A822_1
(ALPHA-BISABOLENE
SYNTHASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 4 ASP A 256
ASP A 172
ARG A 230
ASP A 326
 None
 1.20A 3sdrA-2x05A:
0.4		 3sdrA-2x05A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SDV_A_911A822_0
(ALPHA-BISABOLENE
SYNTHASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 4 ASP A 256
ASP A 172
ARG A 230
ASP A 326
 None
 1.26A 3sdvA-2x05A:
0.8		 3sdvA-2x05A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 GLY A 214
THR A  89
LEU A 369
LYS A 187
ASP A 148
 None
CD  A1907 (-3.4A)
CD  A1907 (-4.9A)
None
None
 1.07A 3sglA-2x05A:
undetectable		 3sglA-2x05A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 TYR A 641
LEU A 386
GLY A 664
GLY A 668
VAL A 618
 None
 1.13A 4a6dA-2x05A:
undetectable		 4a6dA-2x05A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 HIS A 682
GLU A 623
ASN A 763
 None
 0.91A 4bupB-2x05A:
undetectable		 4bupB-2x05A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 8 GLY A 514
GLY A 533
VAL A 519
HIS A 625
 None
 0.67A 4c5nC-2x05A:
undetectable		 4c5nC-2x05A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 ARG A 335
ARG A 311
TRP A 301
 None
CD  A1904 ( 4.8A)
None
 1.35A 4cpzC-2x05A:
undetectable		 4cpzC-2x05A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 ARG A 335
ARG A 311
TRP A 301
 None
CD  A1904 ( 4.8A)
None
 1.30A 4cpzE-2x05A:
undetectable		 4cpzE-2x05A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 ARG A 335
ARG A 311
TRP A 301
 None
CD  A1904 ( 4.8A)
None
 1.34A 4cpzF-2x05A:
undetectable		 4cpzF-2x05A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 ARG A 335
ARG A 311
TRP A 301
 None
CD  A1904 ( 4.8A)
None
 1.30A 4cpzG-2x05A:
undetectable		 4cpzG-2x05A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 LEU A 722
THR A 704
ALA A 702
LEU A 700
 None
 0.82A 4d7bA-2x05A:
undetectable		 4d7bA-2x05A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 8 LEU A 127
VAL A 184
VAL A 151
GLN A 176
 None
 0.89A 4em2A-2x05A:
undetectable		 4em2A-2x05A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 ASN A 854
VAL A 851
ILE A 886
THR A 818
 None
 0.98A 4eyrA-2x05A:
undetectable		 4eyrA-2x05A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 8 LEU A 722
THR A 704
ALA A 702
LEU A 700
 None
 0.76A 4iizB-2x05A:
3.3		 4iizB-2x05A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 8 LEU A 722
THR A 704
ALA A 702
LEU A 700
 None
 0.79A 4ik6B-2x05A:
undetectable		 4ik6B-2x05A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 11 SER A 756
GLY A 757
LEU A 700
GLY A 699
LEU A 356
 None
 1.12A 4kt0A-2x05A:
undetectable
4kt0J-2x05A:
undetectable		 4kt0A-2x05A:
21.42
4kt0J-2x05A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 ASP A 256
VAL A 261
ALA A 260
GLY A 225
THR A 263
 None
 1.21A 4mm8A-2x05A:
undetectable		 4mm8A-2x05A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 5 LEU A 823
SER A 859
LEU A 868
ASN A 890
 None
 1.27A 4n09B-2x05A:
undetectable		 4n09B-2x05A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 ALA A 535
GLY A 534
ASN A 634
GLY A 638
ARG A 627
 None
 0.98A 4obwD-2x05A:
undetectable		 4obwD-2x05A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 LEU A 238
ASN A 239
LEU A 292
LEU A 295
 None
 0.92A 4okwA-2x05A:
undetectable		 4okwA-2x05A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 393
GLY A 395
LEU A 455
ARG A 454
ILE A 640
 None
 1.26A 4p6xA-2x05A:
undetectable		 4p6xA-2x05A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 GLU A 623
TYR A 765
LEU A 767
TYR A 615
 None
 1.13A 4twdF-2x05A:
undetectable
4twdJ-2x05A:
undetectable		 4twdF-2x05A:
14.27
4twdJ-2x05A:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 SER A 540
ASP A 473
ASP A 469
 None
None
X05  A1900 (-3.2A)
 0.82A 4uckA-2x05A:
undetectable		 4uckA-2x05A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 292
LEU A 295
ALA A 245
VAL A 269
ALA A 270
 None
 1.03A 4x20B-2x05A:
undetectable		 4x20B-2x05A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 ALA A 304
LEU A 384
LEU A 380
GLY A 360
PRO A 675
 None
 1.01A 4xi3B-2x05A:
undetectable		 4xi3B-2x05A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 GLY A 534
TYR A 516
TYR A 525
ALA A 535
ASN A 628
 None
X05  A1900 (-3.5A)
None
None
None
 1.16A 4ymgA-2x05A:
undetectable		 4ymgA-2x05A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 GLY A 534
TYR A 516
TYR A 525
ALA A 535
ASN A 628
 None
X05  A1900 (-3.5A)
None
None
None
 1.18A 4ymgB-2x05A:
undetectable		 4ymgB-2x05A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A 388
GLY A 668
ASP A 657
PHE A 656
TYR A 641
 None
 1.37A 5d0yA-2x05A:
undetectable		 5d0yA-2x05A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 PHE A 403
GLU A 451
PHE A 464
GLU A 418
 None
 1.28A 5h4dA-2x05A:
undetectable		 5h4dA-2x05A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 5 HIS A 677
VAL A 724
GLY A 728
ALA A 729
 None
 0.94A 5hwaA-2x05A:
undetectable		 5hwaA-2x05A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 ASP A 772
TRP A 524
HIS A 682
TYR A 641
 None
 1.28A 5ov9A-2x05A:
undetectable		 5ov9A-2x05A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 7 GLN A 786
ASP A 772
TRP A 524
HIS A 682
TYR A 641
 None
 1.40A 5ov9B-2x05A:
undetectable		 5ov9B-2x05A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 HIS A 682
GLU A 623
ASN A 763
 None
 0.95A 5wbvA-2x05A:
undetectable		 5wbvA-2x05A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 HIS A 682
GLU A 623
ASN A 763
 None
 0.96A 5wbvB-2x05A:
undetectable		 5wbvB-2x05A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 TYR A 349
ARG A 347
THR A 637
 None
 0.97A 5z84J-2x05A:
undetectable		 5z84J-2x05A:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 6 SER A  86
ARG A 168
ARG A 217
ASP A 170
 None
 1.20A 5zw4A-2x05A:
undetectable		 5zw4A-2x05A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		3 / 3 GLN A  60
TRP A 121
VAL A 119
 None
 1.00A 6auuA-2x05A:
undetectable		 6auuA-2x05A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 5 TYR A 349
GLN A 348
GLY A 506
ILE A 494
 None
 1.35A 6debB-2x05A:
undetectable		 6debB-2x05A:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 10 GLU A 418
GLY A 200
ASN A 212
THR A 364
GLY A 395
 None
 1.10A 6e5zA-2x05A:
undetectable		 6e5zA-2x05A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 7 ILE A 235
GLY A 267
ARG A 454
ALA A 232
 None
 0.89A 6hd6B-2x05A:
undetectable		 6hd6B-2x05A:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		5 / 10 SER A 756
GLY A 757
LEU A 700
GLY A 699
LEU A 356
 None
 1.16A 6hqbA-2x05A:
undetectable
6hqbJ-2x05A:
undetectable		 6hqbA-2x05A:
5.80
6hqbJ-2x05A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 8 ASP A 192
HIS A 396
GLU A 418
GLU A 431
 None
 1.01A 6mn4A-2x05A:
undetectable		 6mn4A-2x05A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2x05 EXO-BETA-D-GLUCOSAMI
NIDASE
(Amycolatopsis
orientalis) 		4 / 8 ASP A 192
HIS A 396
GLU A 418
GLU A 431
 None
 1.10A 6mn4D-2x05A:
undetectable		 6mn4D-2x05A:
12.93